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The microbiota–gut–brain axis

Microbiota-gut-brain jigsawOur understanding of the complex and bidirectional signalling relationship between the gastrointestinal tract and the brain is evolving quickly. This relationship, dubbed the microbiota-gut-brain axis, is thought to be involved in many aspects of homeostasis in addition to the pathogenesis of several diseases, ranging from neurological and degenerative conditions to autoimmune diseases. 

This cross-journal collection brings together both human and animal studies covering all aspects of the microbiota-gut-brain axis’ role in health and disease, as well as its therapeutic potential. The participating journals, spanning both neuroscience and microbiology, are listed below.

Submissions should be formatted according to individual journal guidelines. Please indicate clearly in the cover letter that the manuscript is to be considered for this collection. 

All manuscripts will undergo standard peer review, and must be submitted through the relevant journal's online submission system by 31st December 2019.

Pre-submission enquiries are welcome.

  1. Content type: Research

    Inflammasomes have been found to interact with the gut microbiota, and this effect is associated with depression, but the mechanisms underlying this interaction have not been elucidated in detail.

    Authors: Yuan Zhang, Rongrong Huang, Mengjing Cheng, Lirui Wang, Jie Chao, Junxu Li, Peng Zheng, Peng Xie, Zhijun Zhang and Honghong Yao

    Citation: Microbiome 2019 7:116

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  2. Content type: Review

    Alzheimer’s disease (AD) is a neurodegenerative disease whose various pathophysiological aspects are still being investigated. Recently, it has been hypothesized that AD may be associated with a dysbiosis of m...

    Authors: Francesco Angelucci, Katerina Cechova, Jana Amlerova and Jakub Hort

    Citation: Journal of Neuroinflammation 2019 16:108

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  3. Content type: Research

    Evidence from preclinical and clinical studies suggests that interactions among the brain, gut, and microbiota may affect the pathophysiology of irritable bowel syndrome (IBS). As disruptions in central and pe...

    Authors: Jennifer S. Labus, Vadim Osadchiy, Elaine Y. Hsiao, Julien Tap, Muriel Derrien, Arpana Gupta, Kirsten Tillisch, Boris Le Nevé, Cecilia Grinsvall, Maria Ljungberg, Lena Öhman, Hans Törnblom, Magnus Simren and Emeran A. Mayer

    Citation: Microbiome 2019 7:45

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  4. Content type: Review

    Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiolog...

    Authors: Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu and Rong-Fu Wang

    Citation: Journal of Neuroinflammation 2019 16:53

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  5. Content type: Research

    Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s diseas...

    Authors: Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin and Federico E. Rey

    Citation: Alzheimer's Research & Therapy 2018 10:124

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  6. Content type: Review

    Antibiotic resistance is by far one of the most important health threats of our time. Only a global concerted effort of several disciplines based on the One-Health concept will help in slowing down this proces...

    Authors: Esther-Maria Antão, Szilvia Vincze, Regina Hanke, Lukas Klimmek, Katarzyna Suchecka, Antina Lübke-Becker and Lothar H. Wieler

    Citation: Gut Pathogens 2018 10:52

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  7. Content type: Review

    Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in ...

    Authors: Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong and Shengmei Zhu

    Citation: Journal of Neuroinflammation 2018 15:339

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  8. Content type: Research

    Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problem...

    Authors: Fang Liu, Kayla Horton-Sparks, Vanessa Hull, Robert W. Li and Verónica Martínez-Cerdeño

    Citation: Molecular Autism 2018 9:61

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