We invite submissions dedicated to exploring the intricate mechanisms underlying DNA methylation and demethylation processes. DNA methylation, catalyzed by DNA methyltransferases, plays a pivotal role in gene regulation and genome stability. Conversely, DNA demethylation mechanisms, whether passive or active, are essential for gene activation and dynamic gene expression patterns. This Collection aims to bring together cutting-edge research elucidating the molecular mechanisms, regulatory pathways, and functional implications of DNA methylation and demethylation. We encourage contributions spanning experimental, computational, and theoretical approaches.
Topics to include:
• Role of DNA methyltransferases in methylation patterning
• Mechanisms of passive and active DNA demethylation
• Regulation of DNA methylation dynamics during development and disease
• Interplay between DNA methylation and histone modifications
• Computational modeling and simulation of DNA methylation dynamics
• Technological advancements in profiling DNA methylation and demethylation
• Therapeutic targeting of DNA methylation for disease intervention
• Evolutionary perspectives on the conservation and divergence of DNA methylation pathways