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Call for papers - Macrophage polarization

Guest Editor

Danli Xie, PhD, Wenzhou Medical University, China

Submission Status: Open   |   Submission Deadline: 20 March 2025

BMC Immunology is calling for submissions to our Collection on Macrophage polarization. Macrophages, crucial players in immune responses, exhibit distinct functional states known as polarization. This Collection invites cutting-edge research on macrophage polarization, exploring topics such as molecular mechanisms, disease pathogenesis, immunomodulatory functions, therapeutic targeting, biomarkers, and translational applications. By fostering collaboration, this initiative aims to advance healthcare by unraveling the complexities of macrophage biology and harnessing their therapeutic potential.

New Content ItemThis Collection supports and amplifies research related to SDG 3: Good Health and Wellbeing.

Meet the Guest Editor

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Danli Xie, PhD, Wenzhou Medical University, China

Dr Danli Xie is an Associate Professor and Vice Dean of the School of Laboratory Medicine and Life Sciences at Wenzhou Medical University. He has been honored as a Zhejiang Provincial High-Level Health Talent and enrolled as an “Outstanding Young Talent” at Wenzhou Medical University. He serves as the Deputy Director of the Youth Committee of the Zhejiang Provincial Microbiology Society. His laboratory is primarily engaged in exploring the interactions between key virulence factor systems in pathogenic Vibrio species and host immune defenses.

About the Collection

BMC Immunology is pleased to announce our latest Collection on Macrophage polarization. Macrophages play a pivotal role in immune responses, with their polarization into distinct functional states critically influencing tissue homeostasis, inflammation, and disease pathogenesis. We invite researchers to contribute their cutting-edge research that unravels the intricacies of macrophage polarization, exploring novel mechanisms, therapeutic targets, and translational applications.

This Collection aims to shed light on various aspects of macrophage polarization, welcoming submissions that delve into, but are not limited to, the following themes:

  • Molecular mechanisms of polarization: in-depth investigations into the signaling pathways and molecular regulators governing macrophage polarization towards distinct functional phenotypes, such as M1 and M2.
  • Role in disease pathogenesis: understanding the contributions of macrophage polarization to the development and progression of diverse diseases, including cancer, infectious diseases, autoimmune disorders, and metabolic syndromes.
  • Immunomodulatory functions: exploration of the immunoregulatory roles of polarized macrophages in orchestrating immune responses, tissue repair, and resolution of inflammation.
  • Therapeutic targeting: advancements in targeting polarized macrophages for therapeutic intervention, including the development of novel pharmacological agents, immunomodulatory strategies, and cell-based therapies.
  • Biomarkers and diagnostics: identification and validation of biomarkers associated with macrophage polarization states for diagnostic, prognostic, and therapeutic monitoring purposes.
  • Translational applications: bridging the gap between basic research and clinical practice, with a focus on translating findings into innovative therapies and personalized medicine approaches.

This Collection aligns with the United Nations Sustainable Development Goal 3: Good Health and Wellbeing. By fostering collaboration among researchers, clinicians, and immunologists, this initiative aims to deepen our understanding of macrophage polarization and pave the way for transformative advancements in healthcare. 

Image credit: © Dr_Microbe /

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original Research Articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select Macrophage polarization from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.