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Lipids in Inflammatory Diseases

Guest edited by:
Professor Christine Meisinger, MPH, University of Augsburg, Germany
Professor Jakob Linseisen, Dr.oec., University of Augsburg, Germany

Lipids in Health and Disease invites you to contribute a manuscript to our new thematic series, "Lipids in Inflammatory Diseases".

Lipids play an essential role in physiological and pathophysiological processes. They act as messengers in inflammation and are critical in processes such as cell migration, apoptosis, autophagy, and cell division. They also contribute to resolving inflammatory reactions.

It has been argued that lipid metabolism and immune system responses regulate each other. Chronic inflammation plays a central role in a range of the most challenging diseases of our time, including heart disease, diabetes, rheumatoid arthritis, cancer, asthma, Alzheimer's disease, sepsis, and acute and chronic infections. The extent to which lipids and lipid metabolism are important in chronic and acute inflammatory diseases with regard to pathogenesis, diagnosis, course, therapy, occurrence of complications, subsequent diseases, and prognosis is increasingly the subject of intensive research.

The aim of this special issue is therefore to collect research papers to generate new insights into the role of lipids in the context of acute and chronic inflammatory diseases. We welcome articles, including original research, systematic reviews and meta-analyses on this relevant topic.

Keywords: lipids, lipoproteins, LDL, HDL, lipoprotein(a), triglycerides, lipotoxicity, inflammation, inflammatory disease, therapy

This collection is no longer accepting submissions.

Submission guidelines can be found here. Articles should be submitted via our submission system, Snapp.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies.

The topics of interest include but are not limited to:

• Involvement of lipids in the pathogenesis of inflammatory diseases
• Mechanisms and molecular pathways affecting lipid and lipoprotein metabolism in inflammatory diseases
• Deeper understanding of the crosstalk between lipids and the immune system and its contribution to a balanced immune reaction
• Impact of lipids on disease progression of inflammatory disorders
• Effect of currently used drugs and other therapies in inflammatory diseases on lipids and lipid metabolism
• Therapeutic targets and effective treatment options for dyslipidemias in acute and chronic inflammatory diseases
• Identification of diagnostic and prognostic lipid markers in inflammatory diseases
• Changes in lipids, lipid metabolism, inflammation and associated stress responses during inflammatory diseases

Questions to be answered:

• How exactly are lipids involved in the pathogenesis of inflammatory diseases?
• How is lipid metabolism altered during an inflammatory disease, and how might it affect immune responses?
• Might a deeper understanding of the crosstalk between lipids and inflammation lead to the identification of targeted anti-inflammatory therapies?
• Are there new lipid mediators with anti-inflammatory effects that could represent new promising therapeutic tools?


  1. Insulin resistance (IR) imposes a significant burden on inflammatory diseases, and the triglyceride-glucose (TyG) index, which is an easily accessible indicator for detecting IR, holds great application potent...

    Authors: Yang Liu, Junjie Yao, Xiaona Xue, Yanan Lv, Sheng Guo and PeiDong Wei
    Citation: Lipids in Health and Disease 2024 23:79
    Content type: Research Published on:

  3. To study the role of gene mutations in the development of severe hypertriglyceridemia (HTG) in patients with hyperlipidemic acute pancreatitis (HLAP), especially different apolipoprotein A5 (APOA5) mutations.

    Authors: Yuxin Liu, Si Dai, Shuqi Qin, Jing Zhou, Zhendan Wang and Guojian Yin
    Citation: Lipids in Health and Disease 2024 23:44
    Content type: Research Published on:

  5. Ferroptosis, is characterized by lipid peroxidation of fatty acids in the presence of iron ions, which leads to cell apoptosis. This leads to the disruption of metabolic pathways, ultimately resulting in liver...

    Authors: Longfei Dai, Wenkang Yuan, Renao Jiang, Zhicheng Zhan, Liangliang Zhang, Xinjian Xu, Yuyang Qian, Wenqi Yang and Zhen Zhang
    Citation: Lipids in Health and Disease 2024 23:23
    Content type: Research Published on:

  6. The presence of gallstones in both the gallbladder and bile ducts is referred to as cholelithiasis. The prevalence of cholecystolithiasis and bile duct stones differs. Observational and Mendelian randomization...

    Authors: Xing-Ming Xie, Tao Liu and Guo-Ying Wang
    Citation: Lipids in Health and Disease 2024 23:8
    Content type: Research Published on:

  7. Acute pancreatitis (AP) is an unpredictable and potentially fatal disorder. A derailed or unbalanced immune response may be the root of the disease’s severe course. Disorders of lipid metabolism are highly cor...

    Authors: Jifeng Liu, Lei Zhong, Yunshu Zhang, Jingyuan Ma, Tong Xie, Xu Chen, Biao Zhang and Dong Shang
    Citation: Lipids in Health and Disease 2024 23:1
    Content type: Research Published on:

  8. The prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and dietary changes. However, currently, there is no clinical multifactor scori...

    Authors: Yi Shuanglian, Zeng Huiling, Lin Xunting, Deng Yifang, Lin Yufen, Xie Shanshan, Si Lijuan and Liu Yunpeng
    Citation: Lipids in Health and Disease 2023 22:218
    Content type: Research Published on:

  9. Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is characterized by a violent cytokine storm-driven inflammation and is associated with a predisposition to severe disease. The treatment strategy for H...

    Authors: Jianjun Wang, Yang Xia, Yuan Cao, Xianfu Cai, Shichun Jiang, Yougang Liao, Mingsong Shi, Huiwen Luo and Decai Wang
    Citation: Lipids in Health and Disease 2023 22:208
    Content type: Review Published on:

  10. Intervertebral disc degeneration (IVDD) is widely recognized as the primary etiological factor underlying low back pain, often necessitating surgical intervention as the sole recourse in severe cases. The meta...

    Authors: Jianye Tan, Meiling Shi, Bin Li, Yuan Liu, Shengzhong Luo and Xigao Cheng
    Citation: Lipids in Health and Disease 2023 22:204
    Content type: Research Published on:

  11. Idiopathic pulmonary fibrosis (IPF) is considered an age-related disease. Age-related changes, along with other factors such as obesity, hormonal imbalances, and various metabolic disorders, lead to ectopic fa...

    Authors: Xiaoyun Cheng, Shuhan Jiang, Boyu Pan, Wei Xie and Jie Meng
    Citation: Lipids in Health and Disease 2023 22:201
    Content type: Review Published on:

  12. Disturbed bile acid homeostasis associated with a rise of primary and a decline of secondary bile acids is a consistent finding in inflammatory bowel diseases (IBDs). Whether fecal bile acids may emerge as bio...

    Authors: Stefanie Sommersberger, Stefan Gunawan, Tanja Elger, Tanja Fererberger, Johanna Loibl, Muriel Huss, Arne Kandulski, Sabrina Krautbauer, Martina Müller, Gerhard Liebisch, Christa Buechler and Hauke Christian Tews
    Citation: Lipids in Health and Disease 2023 22:199
    Content type: Research Published on:

  13. Roughly 10 -15% of global populace suffer from Chronic Kidney Disease(CKD). A major secondary disease that can progress to end-stage renal disease (ESRD) is obesity-associated kidney disease (ORG). Although cl...

    Authors: Yibing Zhou, Ze Chen, Hui Zhou, Bin Niu, Jing Liu, Yinglun Li, Yuqiang Mi and Ping Li
    Citation: Lipids in Health and Disease 2023 22:198
    Content type: Research Published on:

  14. To investigate the correlation between anthropometric indexes [cardiometabolic index (CMI), lipid accumulation products (LAP), waist triglyceride index (WTI), and body mass index (BMI)] and acute pancreatitis ...

    Authors: Qiu Sun, Qingshuai Ren, Liming Du, Shuohua Chen, Shouling Wu, Bing Zhang and Bangmao Wang
    Citation: Lipids in Health and Disease 2023 22:190
    Content type: Research Published on:

  15. Variations in the prevalence and systemic inflammatory (SI) status between non-alcoholic fatty liver disease (NAFLD) and newly defined metabolic dysfunction-associated fatty liver disease (MAFLD) have only bee...

    Authors: Qingdan Liu, Meilan Han, Meilan Li, Xiaoyin Huang, Ruimei Feng, Wanxin Li, Jun Chen, Haiying He, Wenxin Zheng, Zhijian Hu, Shanshan Du and Weimin Ye
    Citation: Lipids in Health and Disease 2023 22:185
    Content type: Research Published on:

  16. Near-infrared irradiation photobiomodulation (NIR-PBM) has been successfully used in periodontal treatment as an adjuvant tool to locally improve cell function and regeneration. Although the relationship betwe...

    Authors: Isadora Martins Ribeiro, Maria Eduarda de Souza Barroso, Edgar Hell Kampke, Larissa Trarbach Figueiredo Braga, Bianca Prandi Campagnaro and Silvana dos Santos Meyrelles
    Citation: Lipids in Health and Disease 2023 22:171
    Content type: Research Published on:

  18. Non-high-density lipoprotein-cholesterol (non-HDL-C) has been identified as a potential biomarker for metabolic syndrome (MetS). However, its predictive capability for MetS varies among different ethnic groups...

    Authors: Fatemeh Vazirian, Susan Darroudi, Hamid Reza Rahimi, MohamadReza Latifi, Behrouz Shakeri, Samaneh Abolbashari, Amir Hooshang Mohammadpour, Habibollah Esmaily, Mohsen Mouhebati, Sara Samadi and Majid Ghayour Mobarhan
    Citation: Lipids in Health and Disease 2023 22:165
    Content type: Research Published on:

  19. Urinary 3-indoxyl sulfate levels as well as fecal short chain fatty acid (SCFA) concentrations are surrogate markers for gut microbiota diversity. Patients with inflammatory bowel diseases (IBDs) and patients ...

    Authors: Hauke Christian Tews, Tanja Elger, Stefan Gunawan, Tanja Fererberger, Stefanie Sommersberger, Johanna Loibl, Muriel Huss, Gerhard Liebisch, Martina Müller, Arne Kandulski and Christa Buechler
    Citation: Lipids in Health and Disease 2023 22:164
    Content type: Research Published on:

  20. Cholesterol metabolism is a risk factor for cardiovascular disease, and recent studies have shown that cholesterol metabolism poses a residual risk of cardiovascular disease even when conventional lipid risk f...

    Authors: Yuxuan Wu, Qinfei Wei, Husheng Li, Han Yang, Yuying Wu, Yiming Yu, Qiansi Chen, Baochang He and Fa Chen
    Citation: Lipids in Health and Disease 2023 22:158
    Content type: Research Published on:

  21. Hepatitis C has been associated with the development of hepatic steatosis, which increases the risk of liver cancer. The microsomal triglyceride transporter protein (MTTP), is a lipid transport protein that me...

    Authors: Xiaoxia Wang, Yu Cao, Jia Guo, Dezhao Li, Haitao Zhang, Qingkun Song and Jun Lu
    Citation: Lipids in Health and Disease 2023 22:154
    Content type: Review Published on:

  22. This study aimed to investigate the association between the Dietary Inflammatory Index (DII) and dyslipidemia, as well as to evaluate the mortality risk associated with DII in participants with dyslipidemia.

    Authors: Xiaozhe Chen, Chunlei Hou, Lei Yao, Jianhua Li, Mingtai Gui, Mingzhu Wang, Xunjie Zhou, Bo Lu and Deyu Fu
    Citation: Lipids in Health and Disease 2023 22:149
    Content type: Research Published on:

  23. The prognostic value of lipoprotein (Lp) (a) in patients who have suffered from coronary artery disease (CAD) has not been fully studied, and the results are inconsistent. This study was conducted to evaluate ...

    Authors: Lin Zhao, Lin Sun, ZengLei Zhang, KunQi Yang, ZuoZhi Li, Man Wang, Yan Zeng, XianLiang Zhou and WeiXian Yang
    Citation: Lipids in Health and Disease 2023 22:141
    Content type: Research Published on:

  24. Hyperlipidemia is closely associated with dietary patterns and inflammation. However, the relationship between hyperlipidemia and the inflammatory potential of diets remains unexplored. The research was conduc...

    Authors: Yu Han, Xijuan Jiang, Yabin Qin, Yile Zhao, Guying Zhang and Chao Liu
    Citation: Lipids in Health and Disease 2023 22:140
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2023 22:161

  25. The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA).

    Authors: Wen-Jia Zhao, Jiang-Hong Deng and Cai-Feng Li
    Citation: Lipids in Health and Disease 2023 22:136
    Content type: Review Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2023 22:148

  26. Insulin resistance is a well-established contributor to inflammation; however, the specific association between the triglyceride glucose (TyG) index, a biomarker reflecting insulin resistance, and arthritis re...

    Authors: Yuxin Yan, Liyu Zhou, Rui La, Ming Jiang, Dinghua Jiang, Lixin Huang, Wu Xu and Qian Wu
    Citation: Lipids in Health and Disease 2023 22:132
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2024 23:60

  27. The global incidence of nonalcoholic fatty liver disease (NAFLD) is rapidly escalating, positioning it as a principal public health challenge with significant implications for population well-being. Given its ...

    Authors: Rui Meng, Hui Wang, Zhikang Si, Xuelin Wang, Zekun Zhao, Haipeng Lu, Yizhan Zheng, Jiaqi Chen, Huan Wang, Jiaqi Hu, Ling Xue, Xiaoming Li, Jian Sun and Jianhui Wu
    Citation: Lipids in Health and Disease 2023 22:123
    Content type: Research Published on:

  28. Lipoprotein lipase (LPL) is the key enzyme responsible for the hydrolysis of triglycerides. Loss-of-function variants in the LPL gene are associated with hypertriglyceridemia (HTG) and HTG-related diseases. Unlik...

    Authors: Yuepeng Hu, Guofu Zhang, Qi Yang, Na Pu, Kaiwei Li, Baiqiang Li, David N. Cooper, Zhihui Tong, Weiqin Li and Jian-Min Chen
    Citation: Lipids in Health and Disease 2023 22:119
    Content type: Research Published on:

  29. Body fat composition is believed to be associated with the progression, medical response, and prognosis of inflammatory bowel disease (IBD). Hence, we conducted this study to explore if fat metrics were associ...

    Authors: Shubei He, Yuxia Huang, Ying Peng, Jin Chai and Kun Chen
    Citation: Lipids in Health and Disease 2023 22:106
    Content type: Research Published on:

  30. Studies have shown that the lipid metabolism mediator leukotriene and prostaglandins are associated with the pathogenesis of allergic rhinitis (AR). The aim of this study was to identify key lipid metabolism-r...

    Authors: Qilei Tao, Yajing Zhu, Tianyu Wang, Yue Deng, Huanhai Liu and Jian Wu
    Citation: Lipids in Health and Disease 2023 22:105
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2023 22:118

  31. Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of t...

    Authors: Daniel L. Pontzen, Martin Bahls, Diana Albrecht, Stephan B. Felix, Marcus Dörr, Till Ittermann, Matthias Nauck and Nele Friedrich
    Citation: Lipids in Health and Disease 2023 22:100
    Content type: Research Published on:

  32. Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH). H...

    Authors: Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao and Yuemin Nan
    Citation: Lipids in Health and Disease 2023 22:99
    Content type: Research Published on:

  33. Apolipoproteins and lipoprotein(a) are associated with various cardiometabolic diseases, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, among others. This systematic review and me...

    Authors: Juan R. Ulloque-Badaracco, Ali Al-kassab-Córdova, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Miguel Huayta-Cortez, Ximena L. Carballo-Tello, Rosa A. Seminario-Amez, Percy Herrera-Añazco and Vicente A. Benites-Zapata
    Citation: Lipids in Health and Disease 2023 22:98
    Content type: Review Published on:

  34. Atherosclerosis is now the main cause of cardiac-cerebral vascular diseases around the world. Disturbances in lipid metabolism have an essential role in the development and progression of atherosclerosis. Thus...

    Authors: Xue Pan, Jifeng Liu, Lei Zhong, Yunshu Zhang, Chaosheng Liu, Jing Gao and Min Pang
    Citation: Lipids in Health and Disease 2023 22:96
    Content type: Research Published on:

  35. Obesity-related chronic inflammation is closely related to the ability of immune cells to adapt to the body’s needs, research has shown that excess FAs can further activate pro-inflammatory transcription facto...

    Authors: Su Liqiang, Li Fang-Hui, Quan Minghui, Yang Yanan and Chen Haichun
    Citation: Lipids in Health and Disease 2023 22:93
    Content type: Research Published on:

  36. Twenty-three percent of patients are diagnosed with diabetes mellitus after the first episode of acute pancreatitis. The incidence of post-acute pancreatitis diabetes mellitus is significantly higher than that...

    Authors: Xiamin Tu, Qingxie Liu, Lin Chen, Jie Li, Xiaoping Yu, Xiuping Jiao, Ningzhi Wang, Lianghao Hu, Yuan Yuan, Weijuan Gong, Yanbing Ding, Xiaolei Shi, Weiming Xiao and Guotao Lu
    Citation: Lipids in Health and Disease 2023 22:82
    Content type: Research Published on:

  37. Hepatitis E virus (HEV)-triggered acute-on-chronic liver failure (ACLF) has unacceptably high short-term mortality. However, it is unclear whether the existing predictive scoring models are applicable to evalu...

    Authors: Chong Chen, Aihong Zhu, Shanke Ye, Weixia Li, Ling Fei, Qin Huang and Liang Chen
    Citation: Lipids in Health and Disease 2023 22:80
    Content type: Research Published on:

  38. Endotoxemia and sepsis induce neuroinflammation and increase the risk of neurodegenerative disorders although the mechanism by which peripheral infection leads to brain inflammation is not well understood. Whi...

    Authors: Daniel E. Radford-Smith, Abi G. Yates, Laila Rizvi, Daniel C. Anthony and Fay Probert
    Citation: Lipids in Health and Disease 2023 22:54
    Content type: Research Published on:

  39. Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that exerts a variety of biological functions, including immune, cardiovascular, and neurological regulation as well as tumor promotion, through high-af...

    Authors: Yuechun Zhao, Yuheng Zhang, Jiaqi Li, Ningxin Zhang, Qiubai Jin, Yuxia Qi and Ping Song
    Citation: Lipids in Health and Disease 2023 22:52
    Content type: Review Published on: