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Inflammation and its role in thrombosis

Prof Domenico Prisco

This collection of articles in Thrombosis Journal looks  at the relationship between the coagulation and immune systems and goes on to investigate this relationship in a number of conditions, such as systemic lupus erythematosus and intestinal bowel disease.

In recent years it has become increasing clear that the immune system and coagulation pathways interact and influence one another. Inflammation-induced thrombosis is considered a feature of several autoimmune diseases and thus such findings have important consequences for the treatment and management of such diseases.

  1. Content type: Review

    Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediter...

    Authors: Micaela La Regina, Francesco Orlandini and Raffaele Manna

    Citation: Thrombosis Journal 2015 13:19

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  2. Content type: Review

    The contact system, also named as plasma kallikrein-kinin system, consists of three serine proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and the nonenzymatic cofactor...

    Authors: Yi Wu

    Citation: Thrombosis Journal 2015 13:17

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  3. Content type: Review

    Systemic Lupus Erythematosus (SLE) is an acquired, multiorgan, autoimmune disease. Clinical presentation is extremely variable and heterogeneous. It has been shown that SLE itself is an independent risk factor...

    Authors: Mario Bazzan, Antonella Vaccarino and Fabio Marletto

    Citation: Thrombosis Journal 2015 13:16

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  4. Content type: Review

    In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected.

    Authors: Giacomo Emmi, Elena Silvestri, Danilo Squatrito, Amedeo Amedei, Elena Niccolai, Mario Milco D’Elios, Chiara Della Bella, Alessia Grassi, Matteo Becatti, Claudia Fiorillo, Lorenzo Emmi, Augusto Vaglio and Domenico Prisco

    Citation: Thrombosis Journal 2015 13:15

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  5. Content type: Review

    Inflammatory bowel disease affects more than 2 million people in Europe, with almost 20% of patients being diagnosed in pediatric age. Patients with inflammatory bowel disease are at increased risk of thromboe...

    Authors: Martina Giannotta, Gherardo Tapete, Giacomo Emmi, Elena Silvestri and Monica Milla

    Citation: Thrombosis Journal 2015 13:14

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