Perioperative Medicine invites participating authors to submit to our Collection on Innovative Perioperative Trial Designs.
Randomised clinical trials are the established gold standard for testing new medical treatments. However, there is increasing recognition that conventional clinical trials are too expensive, and too slow to generate new evidence. The UK’s National Institute for Health & Care Research has encouraged a move towards more efficient and cost-effective trial designs. The potential benefits of developments such as platform trials were highlighted during the Covid pandemic, when multiple treatments were tested in a highly compressed timeframe.
This collection will give an overview of a range of innovative trial designs that are beginning to be adopted into perioperative evidence generation. Expert authors with direct experience will introduce a number of aspects ranging from novel trial structures, methods to enhance large-scale patient recruitment, making the best use of existing datasets, and alternative non-randomised methods. Readers will be given a comprehensive review of these novel methods, their suitable applications in perioperative research, and key advantages and limitations.
