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Intraoperative radiation therapy (IORT)

IORT delivers a single concentrated radiation dose to a limited volume of tissue during a surgical procedure. This series from Radiation Oncology provides an overview of the role of IORT in treating a number of diseases.

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  1. Review

    Present state and issues in IORT Physics

    Literature was reviewed to assess the physical aspects governing the present and emerging technologies used in intraoperative radiation therapy (IORT). Three major technologies were identified: treatment with ...

    Frank W. Hensley

    Radiation Oncology 2017 12:37

    Published on: 27 January 2017

  2. Review

    Intraoperative radiation therapy (IORT) in soft-tissue sarcoma

    Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the...

    Falk Roeder and Robert Krempien

    Radiation Oncology 2017 12:20

    Published on: 19 January 2017

  3. Review

    Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

    Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectivenes...

    Carsten Herskind, Lin Ma, Qi Liu, Bo Zhang, Frank Schneider, Marlon R. Veldwijk and Frederik Wenz

    Radiation Oncology 2017 12:24

    Published on: 19 January 2017

  4. Review

    Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

    Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in ...

    Marco Krengli, Carla Pisani, Letizia Deantonio, Daniela Surico, Alessandro Volpe, Nicola Surico and Carlo Terrone

    Radiation Oncology 2017 12:18

    Published on: 19 January 2017

  5. Review

    Intraoperative radiation therapy (IORT) in pancreatic cancer

    Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy re...

    Robert Krempien and Falk Roeder

    Radiation Oncology 2017 12:8

    Published on: 19 January 2017

  6. Review

    Intraoperative radiotherapy (IORT) as boost in breast cancer

    The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT precedin...

    Felix Sedlmayer, Roland Reitsamer, Frederik Wenz, Elena Sperk, Christoph Fussl, Julia Kaiser, Ingrid Ziegler, Franz Zehentmayr, Heinz Deutschmann, Peter Kopp and Gerd Fastner

    Radiation Oncology 2017 12:23

    Published on: 19 January 2017