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Ion beam therapy – Results from a clinical research group at the Heidelberg Ion Beam Therapy Center

New Content Item (4)Guest Edited by Prof. Oliver Jäkel

Radiotherapy with heavy charged particles has been pioneered by Heidelberg University in the last 20 years. Starting in 1997, scanned carbon ions were explored for radiotherapy at the GSI Helmholtz Centre for Heavy Ion Research and since 2009, at the Heidelberg Ion Beam Therapy Center (HIT) at the University Hospital Heidelberg. At HIT, proton and carbon ions have been used for treatments of more than 4000 patients until mid-2017. Currently helium and oxygen ions are investigated in preclinical research projects.  The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) has funded preclinical and clinical research at HIT within a clinical research group for many years.

This special issue published in Radiation Oncology summarizes some of the highlights of this research group and gathers articles from the field of medical physics and radiobiology, as well as clinical results for a variety of tumor entities.  The main focus is on the effects of organ motion in scanned beam delivery, the radiobiological effectiveness of light ion beams and biomarkers applied.  The clinical application addresses tumors of the brain, skull base and lung, as well as hepatic and pancreatic tumors.

  1. Content type: Research

    To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons.

    Authors: Falk Stade, Jan-Oliver Dittmar, Oliver Jäkel, Clemens Kratochwil, Uwe Haberkorn, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:58

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  2. Content type: Research

    Meningiomas of the skull base account for 25–30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantia...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:54

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  3. Content type: Research

    The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

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  4. Content type: Research

    Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico ...

    Authors: Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus and Katia Parodi

    Citation: Radiation Oncology 2018 13:2

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  5. Content type: Research

    Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhi...

    Authors: Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E. Lipson, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2018 13:1

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  6. Content type: Research

    Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibi...

    Authors: Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2017 12:208

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  7. Content type: Review

    Pancreatic cancer, especially in case of locally advanced stage has a poor prognosis. Radiotherapy in general can lead to tumor volume reduction, but further improvements, such as ion beam therapy have to be p...

    Authors: Constantin Dreher, Daniel Habermehl, Oliver Jäkel and Stephanie E. Combs

    Citation: Radiation Oncology 2017 12:203

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  8. Content type: Review

    The rapid rise of particle therapy across the world necessitates evidence to justify its ever-increasing utilization. This narrative review summarizes the current status of these technologies on treatment of b...

    Authors: Sebastian Adeberg, Semi B. Harrabi, Vivek Verma, Denise Bernhardt, Nicole Grau, Jürgen Debus and Stefan Rieken

    Citation: Radiation Oncology 2017 12:193

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  9. Content type: Research

    To summarize the research activities of the “clinical research group heavy ion therapy”, funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypo...

    Authors: Christin Glowa, Peter Peschke, Stephan Brons, Oliver C. Neels, Klaus Kopka, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2017 12:174

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  10. Content type: Research

    Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a c...

    Authors: Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Christian Schwager, Julia Bauer, Bing Yang, Liji Cao, Min Jia, Andrea Mairani, Ming Chen, Longhua Chen, Juergen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2017 12:172

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  11. Content type: Review

    Scanned ion beam therapy has special demands for treatment of intra-fractionally moving tumors such as lesions in lung or liver. Interplay effects between beam and organ motion can in those settings lead to un...

    Authors: Christoph Bert and Klaus Herfarth

    Citation: Radiation Oncology 2017 12:170

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  12. Content type: Research

    For irradiation treatment planning of meningiomas the use of PET-scans is well established. The most frequently used tracers are either based on amino acids or the somatostatin receptor ligand DOTATOC. Since u...

    Authors: Jan Oliver Dittmar, Clemens Kratochwil, Anne Dittmar, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Frederik L. Giesel, Uwe Haberkorn, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2017 12:169

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