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The interplay between the host and HSV-1 infection

Edited by Chunfu Zheng

This article collection, published in Virology Journal, is to help us not only improve our knowledge of virus-host interactions but also develop novel antiviral approaches and vaccines against Herpes simplex virus type 1 (HSV-1) infection. HSV-1 is a typical human-restricted pathogen, which is carried by 50-90% of the population worldwide, with higher frequencies in developing countries. HSV-1 is well known for its ability to establish a lifelong latent infection in neurons and trigger reactivation and lytic infection, mainly in epithelial or mucosal cells.

Although HSV-1 was identified over 100 years ago, the battle between HSV-1 and the host continues, as there is no vaccine yet available, and HSV-1 is still one of the major infectious diseases worldwide.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections in Virology Journal.

  1. Research

    Prevalence of hepatitis-C virus genotypes and potential transmission risks in Malakand Khyber Pakhtunkhwa, Pakistan

    Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam

    Virology Journal 2017 14:160

    Published on: 22 August 2017

  2. Research

    Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions

    Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...

    Melanie Ott, Débora Marques, Christina Funk and Susanne M. Bailer

    Virology Journal 2016 13:175

    Published on: 20 October 2016

  3. Research

    Visualizing the replicating HSV-1 virus using STED super-resolution microscopy

    Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...

    Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou

    Virology Journal 2016 13:65

    Published on: 9 April 2016

  4. Review

    Evasion of host antiviral innate immunity by HSV-1, an update

    Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...

    Chenhe Su, Guoqing Zhan and Chunfu Zheng

    Virology Journal 2016 13:38

    Published on: 8 March 2016