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The interplay between the host and HSV-1 infection

Edited by Chunfu Zheng

This article collection, published in Virology Journal, is to help us not only improve our knowledge of virus-host interactions but also develop novel antiviral approaches and vaccines against Herpes simplex virus type 1 (HSV-1) infection. HSV-1 is a typical human-restricted pathogen, which is carried by 50-90% of the population worldwide, with higher frequencies in developing countries. HSV-1 is well known for its ability to establish a lifelong latent infection in neurons and trigger reactivation and lytic infection, mainly in epithelial or mucosal cells.

Although HSV-1 was identified over 100 years ago, the battle between HSV-1 and the host continues, as there is no vaccine yet available, and HSV-1 is still one of the major infectious diseases worldwide.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections in Virology Journal.

  1. Herpes simplex virus (HSV) can cause encephalitis. Its infected cell polypeptide 47 (ICP47), encoded by immediate-early gene US12, promotes immune escape. ICP47 was modified in the clinically approved oncolytic H...

    Authors: Jun-Ting Cheng, Ying-Ying Wang, Lin-Zhong Zhu, Ying Zhang, Wen-Qi Cai, Zi-Wen Han, Yang Zhou, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Hui-Yu Yang, Shu-Zhong Cui, Zhaowu Ma, Bing-Rong Liu and Hong-Wu Xin

    Citation: Virology Journal 2020 17:101

    Content type: Research

    Published on:

  2. Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and s...

    Authors: Erlin Wang, Yunshuang Ye, Ke Zhang, Jinlong Yang, Daohua Gong, Jianhua Zhang, Renjun Hong, Huan Zhang, Lihong Li, Guijun Chen, Liping Yang, Jianmei Liu, Hanyu Cao, Ting Du, Nigel W. Fraser, Le Cheng…

    Citation: Virology Journal 2020 17:95

    Content type: Research

    Published on:

    The Correction to this article has been published in Virology Journal 2020 17:150

  3. Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV gen...

    Authors: Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor and Naser M. Abd El-Salam

    Citation: Virology Journal 2017 14:160

    Content type: Research

    Published on:

  4. Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...

    Authors: Melanie Ott, Débora Marques, Christina Funk and Susanne M. Bailer

    Citation: Virology Journal 2016 13:175

    Content type: Research

    Published on:

  5. HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the me...

    Authors: Yalan Liu, Mei Li, Di Zhang, Mudan Zhang and Qinxue Hu

    Citation: Virology Journal 2016 13:154

    Content type: Research

    Published on:

  6. One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. Herpes Simplex Virus type I (HSV-1) latently...

    Authors: Benxia Hu, Yongxia Huo, Guijun Chen, Liping Yang, Dongdong Wu and Jumin Zhou

    Citation: Virology Journal 2016 13:137

    Content type: Research

    Published on:

  7. Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...

    Authors: Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou

    Citation: Virology Journal 2016 13:65

    Content type: Research

    Published on:

  8. Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...

    Authors: Chenhe Su, Guoqing Zhan and Chunfu Zheng

    Citation: Virology Journal 2016 13:38

    Content type: Review

    Published on:

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