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Glial and Vascular Contributions to Neurodegenerative Diseases

Guest Editors:
Robert Vassar:
Northwestern University, USA
Hui Zheng: Baylor College of Medicine, USA

Submission Status: Open


Molecular Neurodegeneration is presenting a new Collection on "Glial and Vascular Contributions to Neurodegenerative Diseases".



Image credit: Artur / stock.adobe.com

About the collection

Glia and vasculature play critical roles in maintaining the integrity of the central nervous system. Glia, such as astrocytes and microglia, respond to the brain microenvironment to modulate their gene expression programs and activation states, the dysfunction of which contributes to progression of neurodegenerative diseases. Similarly, the vasculature also plays a crucial role in CNS function by regulating blood flow and nutrient delivery to the brain.

Abnormalities in the blood-brain barrier can lead to peripheral infiltration of immune cells, exacerbating neurodegeneration. Additionally, age-related changes in the vasculature, such as reduced blood flow, can lead to functional decline. Therefore, understanding the role of glia and the vasculature in health and disease will facilitate the discovery of novel therapeutic strategies for the treatment of neurodegenerative diseases. Owing to the development of new model systems, such as iPSCs and organoids, and powerful technologies, in particular single cell and spatial transcriptomics, the field has witnessed exciting progress in the past several years.

This review series covers the latest development of these important topics by well-known experts in the field and is an outgrowth from the International Society for Molecular Neurodegeneration Conference: Glial and Vascular Contributions to Neurodegenerative Diseases (October 10-12, 2022, Athens, Greece).

  1. Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. Herei...

    Authors: Ari Sudwarts and Gopal Thinakaran
    Citation: Molecular Neurodegeneration 2023 18:90
  2. This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). Humans have a perip...

    Authors: Tetiana Poliakova and Cheryl L. Wellington
    Citation: Molecular Neurodegeneration 2023 18:86
  3. DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase...

    Authors: Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin and Li Gan
    Citation: Molecular Neurodegeneration 2023 18:79
  4. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons, resulting in muscle weakness, atrophy, paralysis, and eventually...

    Authors: Manling Xie, Praveen N. Pallegar, Sebastian Parusel, Aivi T. Nguyen and Long-Jun Wu
    Citation: Molecular Neurodegeneration 2023 18:75
  5. Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-str...

    Authors: Yasuteru Inoue, Francis Shue, Guojun Bu and Takahisa Kanekiyo
    Citation: Molecular Neurodegeneration 2023 18:46

Submission Guidelines

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Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via the submission system. During the submission process you will be asked whether you are submitting to an Article Collection, please select "Glial and Vascular Contributions to Neurodegenerative Diseases" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.