Biology Direct welcomes submissions for a new Collection of structural biology articles. The Collection will include contributions with significant impact on understanding the architecture and function of biological macromolecules, advancing biological theory, and fostering biotechnological/medical applications.
Context and Meaning
As we progress into the information age – a time of increasing impact of technology on all fronts – structural biology is undergoing a transformative shift. Contemporary approaches, such as cryo-electron microscopy, X-ray crystallography, and nuclear magnetic resonance spectroscopy, allow fast-efficient imaging of macromolecular structures in atomic detail. These innovations are critical for characterizing the complex architecture of proteins, nucleic acids, and other biomolecules, which is fundamental for understanding their function and role in various biological processes. Information obtained through structural biology forms the bases for the development of novel therapeutic strategies, designing new biomolecules, and boosting our overall understanding of the molecular mechanisms constituting life.
To fully exploit these advances, we are facing challenges for analysis, interpretation, and integration. The ability to translate the structural information into functional insights and practical application lags far behind data generation. This Collection aims to showcase recent advances and ongoing efforts to address these challenges and leverage structural biology to drive scientific discovery and innovation.
Call for Papers
We welcome interdisciplinary research and perspectives in innovative approaches for understanding the structure and function of biological macromolecules. Contributions should highlight new methodologies, theoretical frameworks, or applications that push forward our knowledge on biological matter at the frontier of its interface with biotechnology and medicine.
Topics of Interest:
- Structure of Proteins. Modern methodologies with high-level techniques for the determination of the structures of proteins. Research on intrinsically disordered proteins or domains, and implications for their functions and roles in vivo, will be particularly welcome.
- Structures of Nucleic Acids. Research in the DNA and RNA structural biology and research in their complexes, their role in genetic regulations, and cell functioning.
- Molecular Dynamics and Simulations. Computational approaches to model and simulate the behavior of biomolecules, offering a deeper understanding of their dynamics and interactions.
- Structure-Based Drug Design. The science of designing new therapeutic agents and optimization through the knowledge of structure, hence speeding up the discovery of more targeted treatment.
- Macromolecular Complexes. Investigations into the structure and function of large biomolecular assemblies, revealing their mechanisms and biological significance.
- Innovative Analytical Techniques. Development and application of new technologies and methodologies for structural analysis, enhancing the resolution, time dependence and accuracy of structural data.