The articles in this series focus on sarcoma epidemiology as well as their association with inherited syndromes. Syndromic cancers represent a powerful source of information as they have always provided invaluable insights into the molecular pathogenesis of neoplastic diseases. In this perspective, animal models represent an extremely helpful tool to further elucidate the molecular mechanisms underlying sarcomagenesis.
Exposure to ionizing radiations as a predisposing factor to sarcoma development has understandably been the source of sharp debate to the extent that there exists a strong need to focus on this potential pathogenetic link. It is hoped that this series will not only help in clarifying important aspects of sarcoma biology but also will set the field for further research and scientific debate.
Publication of this thematic series has been supported by funding from the European Union Seventh Framework Programme under grant agreement n°278742 - Eurosarc.