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Ebola research highlights

Top left to right: © Sam Taylor/Ärzte ohne Grenzen / dpa, © narvikk / Getty Images / iStock Bottom: © Cynthia Goldsmith / CDCOn 17 July 2019, the Ebola virus disease outbreak in the Democratic Republic of the Congo was declared a Public Health Emergency of International Concern by the World Health Organization. Relevant research published from 2013 onwards in BMC and SpringerOpen journals is collected here for the convenience of researchers and healthcare workers.

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  1. Content type: Research

    The state of the Guinean health workforce is one of the country’s bottlenecks in advancing health outcomes. The impact of the 2014–2015 Ebola virus disease outbreak and resulting international attention has pr...

    Authors: Remco van de Pas, Delphin Kolie, Alexandre Delamou and Wim Van Damme

    Citation: Human Resources for Health 2019 17:63

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  2. Content type: Case report

    The authors report a 1 month follow up of a neonate described as “miracle baby” because she was born Ebola virus disease-free and survived after her mother was infected with Ebola virus during the third trimes...

    Authors: N. Kasereka Baraka, Mupenzi Mumbere and Evie Ndombe

    Citation: BMC Pediatrics 2019 19:202

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  3. Content type: Research article

    The 2014–2016 West Africa Ebola epidemic highlighted the difficulty of collecting patient information during emergencies, especially in highly infectious environments. Health information systems (HISs) appropr...

    Authors: Shefali Oza, Kevin Wing, Alieu Amara Sesay, Sabah Boufkhed, Catherine Houlihan, Lahai Vandi, Sahr Charles Sebba, Catherine R. McGowan, Rachael Cummings and Francesco Checchi

    Citation: BMC Medical Informatics and Decision Making 2019 19:100

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  4. Content type: Research article

    Management of Ebola virus disease (EVD) has historically focused on infection prevention, case detection and supportive care. Several specific anti-Ebola therapies have been investigated, including during the ...

    Authors: James S. Lee, Neill K. J. Adhikari, Henry Y. Kwon, Koren Teo, Reed Siemieniuk, François Lamontagne, Adrienne Chan, Sharmistha Mishra, Srinivas Murthy, Peter Kiiza, Jan Hajek, Elhadj I. Bah, Marie-Claire Lamah, Raymond Kao and Robert A. Fowler

    Citation: BMC Infectious Diseases 2019 19:376

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  5. Content type: Research article

    Information and emotions towards public health issues could spread widely through online social networks. Although aggregate metrics on the volume of information diffusion are available, we know little about h...

    Authors: Hai Liang, Isaac Chun-Hai Fung, Zion Tsz Ho Tse, Jingjing Yin, Chung-Hong Chan, Laura E. Pechta, Belinda J. Smith, Rossmary D. Marquez-Lameda, Martin I. Meltzer, Keri M. Lubell and King-Wa Fu

    Citation: BMC Public Health 2019 19:438

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  6. Content type: Research

    The 2013–2014 West African Ebola outbreak highlighted how the world’s weakest health systems threaten global health security and heralded huge support for their recovery. All three Ebola-affected countries had...

    Authors: Barbara McPake, Prarthna Dayal and Christopher H. Herbst

    Citation: Human Resources for Health 2019 17:19

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  7. Content type: Case report

    The 2014–2016 Ebola virus epidemic in West Africa was the largest outbreak of Ebola virus disease (EVD) in history. Clarifying the influence of other prevalent diseases such as human immunodeficiency virus inf...

    Authors: William J. Liu, Hai-Yang Hu, Qiu-Dong Su, Zhe Zhang, Yang Liu, Yu-Lan Sun, Xian-Da Yang, Da-Peng Sun, Shao-Jian Cai, Xiu-Xu Yang, Idrissa Kamara, Abdul Kamara, Matt Lebby, Brima Kargbo, Patricia Ongpin, Xiao-Ping Dong…

    Citation: Infectious Diseases of Poverty 2019 8:15

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  8. Content type: Research

    In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pa...

    Authors: Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Raven E. Reitstetter, Christopher R. Mahone, Sylvia Trevino, Kelly Wetzel, Ginger C. Donnelly, Cary Retterer, Robert B. Norgren Jr., Rekha G. Panchal, Travis K. Warren, Sina Bavari and Lisa H. Cazares

    Citation: Clinical Proteomics 2019 16:7

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  9. Content type: Review

    Although short-range large-droplet transmission is possible for most respiratory infectious agents, deciding on whether the same agent is also airborne has a potentially huge impact on the types (and costs) of...

    Authors: Raymond Tellier, Yuguo Li, Benjamin J. Cowling and Julian W. Tang

    Citation: BMC Infectious Diseases 2019 19:101

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  10. Content type: Research article

    The West Africa Ebola Virus Disease (EVD) outbreak in 2014–2016 was declared by the World Health Organization (WHO) a public health emergency of international concern. Most of the previous studies done in Sier...

    Authors: Jia Bainga Kangbai, Christian Heumann, Michael Hoelscher, Foday Sahr and Guenter Froeschl

    Citation: BMC Infectious Diseases 2019 19:81

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  11. Content type: Review

    Fragmentation across governance structures, funding, and external actor engagement in Sierra Leone continues to challenge the efficiency and coherence of health sector activities and impedes sustained health s...

    Authors: Arwen Barr, Lauryn Garrett, Robert Marten and Sowmya Kadandale

    Citation: Globalization and Health 2019 15:8

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  12. Content type: Research article

    Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently,...

    Authors: Hari Krishna Ananthula, Scott Parker, Erin Touchette, R. Mark Buller, Gopi Patel, Daniel Kalman, Johanna S. Salzer, Nadia Gallardo-Romero, Victoria Olson, Inger K. Damon, Tessa Moir-Savitz, Larry Sallans, Milton H. Werner, Catherine M. Sherwin and Pankaj B. Desai

    Citation: BMC Pharmacology and Toxicology 2018 19:80

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  13. Content type: Research

    Ebola still remains as one of the most problematic infectious diseases in Africa with a high rate of mortality. Although this disease has been known for an almost half-century, there are no vaccines and drugs ...

    Authors: Mochammad Arfin Fardiansyah Nasution, Erwin Prasetya Toepak, Ahmad Husein Alkaff and Usman Sumo Friend Tambunan

    Citation: BMC Bioinformatics 2018 19(Suppl 14):419

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    This article is part of a Supplement: Volume 19 Supplement 14

  14. Content type: Case study

    West African countries Liberia, Sierra Leone, and Guinea experienced the largest and longest epidemic of Ebola virus disease from 2014 to 2016; after the epidemic was declared to be over, Liberia, Guinea, and ...

    Authors: Cristina Carias, Bishwa B. Adhikari, Fatima Ravat, Martin I. Meltzer and Barbara J. Marston

    Citation: Infectious Diseases of Poverty 2018 7:113

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  15. Content type: Research

    Disruption of malaria control strategies during the West African 2014–2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, s...

    Authors: Guillermo Martínez-Pérez, Dawoh Peter Lansana, Senga Omeonga, Himanshu Gupta, Bondey Breeze-Barry, Raquel González, Azucena Bardají, Adelaida Sarukhan, James D. K. Goteh, Edith Tody, Pau Cisteró, Benard Benda, Juwe D. Kercula, Fanta D. Kibungu, Ana Meyer García-Sípido, Quique Bassat…

    Citation: Malaria Journal 2018 17:357

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  16. Content type: Research article

    Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and int...

    Authors: Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba and Misaki Wayengera

    Citation: BMC Infectious Diseases 2018 18:498

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  17. Content type: Research

    Sierra Leone has one of the highest maternal mortality rates in the world. Encouraging the use of skilled birth attendance in health facilities is an important step in the endeavor to increase the number of sa...

    Authors: Stefanie Theuring, Alimamy Philip Koroma and Gundel Harms

    Citation: Reproductive Health 2018 15:155

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  18. Content type: Research

    Currently, no FDA-approved vaccines or treatments are available for Ebola virus disease (EVD), and therapy remains largely supportive. Ebola virus (EBOV) has broad tissue tropism and can infect a variety of ce...

    Authors: Manasi Tamhankar, Dawn M. Gerhardt, Richard S. Bennett, Nicole Murphy, Peter B. Jahrling and Jean L. Patterson

    Citation: Virology Journal 2018 15:135

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  19. Content type: Research Article

    Health care workers are at the frontline in the fight against infectious disease, and as a result are at a high risk of infection. During the 2014–2015 Ebola outbreak in West Africa, many health care workers c...

    Authors: Ying Li, Huan Wang, Xu-Rui Jin, Xiang Li, Michelle Pender, Cai-Ping Song, Sheng-Lan Tang, Jia Cao, Hao Wu and Yun-Gui Wang

    Citation: Infectious Diseases of Poverty 2018 7:92

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  20. Content type: Research article

    Sierra Leone is pursuing multiple initiatives to establish in-country postgraduate medical education (PGME), as part of national efforts to strengthen the health workforce. This paper explored the career prefe...

    Authors: Aniek Woodward, Euphemia Gooding Lake, Natarajan Rajaraman and Andrew Leather

    Citation: BMC Medical Education 2018 18:199

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  21. Content type: Research

    Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. These interactions range from the initial binding of viral coat proteins to host membrane receptor to ...

    Authors: Xiang Zhou, Byungkyu Park, Daesik Choi and Kyungsook Han

    Citation: BMC Genomics 2018 19(Suppl 6):568

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    This article is part of a Supplement: Volume 19 Supplement 6

  22. Content type: Research

    The 2014–2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host factors/pathways essential for the virus are advanta...

    Authors: Scott Martin, Abhilash I. Chiramel, Marie Luisa Schmidt, Yu-Chi Chen, Nadia Whitt, Ari Watt, Eric C. Dunham, Kyle Shifflett, Shelby Traeger, Anne Leske, Eugen Buehler, Cynthia Martellaro, Janine Brandt, Lisa Wendt, Andreas Müller, Stephanie Peitsch…

    Citation: Genome Medicine 2018 10:58

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  23. Content type: Commentary

    The 2014–2016 Ebola virus disease (EVD) outbreak in West Africa was of unprecedented magnitude with a total of 28,616 suspected, probable, and confirmed cases reported in Guinea, Liberia, and Sierra Leone.

    Authors: Linda M. Mobula, Jolene H. Nakao, Sonia Walia, Justin Pendarvis, Peter Morris and David Townes

    Citation: Journal of International Humanitarian Action 2018 3:10

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  24. Content type: Research

    Pandemics pose significant security/stability risks to nations with fragile infrastructures. We evaluated characteristics of the 2014 West African Ebola outbreak to elucidate lessons learned for managing trans...

    Authors: Aaron M. Wendelboe, Micah McCumber, Julie Erb-Alvarez, Nicholas Mould, Richard W. Childs and James L. Regens

    Citation: Globalization and Health 2018 14:75

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  25. Content type: Research

    Malaria case management in the context of the 2014–2016 West African Ebola virus disease (EVD) epidemic was complicated by a similar initial clinical presentation of the two diseases. In September 2014, the Wo...

    Authors: Ian Hennessee, Timothée Guilavogui, Alioune Camara, Eric S. Halsey, Barbara Marston, Deborah McFarland, Matthew Freeman and Mateusz M. Plucinski

    Citation: Malaria Journal 2018 17:230

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  26. Content type: Research article

    In 2014–2016, West Africa faced the most deadly Ebola Virus Disease (EVD) outbreak in history. A key strategy to overcome this outbreak was continual staff training in Infection Prevention and Control (IPC), w...

    Authors: Mory Keïta, Ansoumane Yassima Camara, Falaye Traoré, Mohamed ElMady Camara, André Kpanamou, Sékou Camara, Aminata Tolno, Bienvenu Houndjo, Fatimatou Diallo, Fatoumata Conté and Lorenzo Subissi

    Citation: BMC Public Health 2018 18:547

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  27. Content type: Research

    The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six...

    Authors: Ameh S. James, Shawn Todd, Nina M. Pollak, Glenn A. Marsh and Joanne Macdonald

    Citation: Virology Journal 2018 15:75

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  28. Content type: Research

    An unprecedented epidemic of Ebola virus disease (EVD) affected Guinea in 2014 and 2015. It weakened the already fragile Guinean health system. This study aimed to assess the effects of the outbreak on Prevent...

    Authors: Niouma Nestor Leno, Alexandre Delamou, Youssouf Koita, Thierno Souleymane Diallo, Abdoulaye Kaba, Therese Delvaux, Wim Van Damme and Marie Laga

    Citation: Reproductive Health 2018 15:60

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  29. Content type: Research article

    The 2014 Ebola Virus Disease epidemic evolved in alarming ways in Sierra Leone spreading to all districts. The country struggled to control it against a backdrop of a health system that was already over-burden...

    Authors: Joanna Raven, Haja Wurie and Sophie Witter

    Citation: BMC Health Services Research 2018 18:251

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  30. Content type: Research

    Adoption of prevention and therapeutic innovations to ensure that National Malaria Control Programmes meet their incidence reduction targets is highly dependent on the conduct of rigorous clinical trials. In L...

    Authors: Guillermo Martínez Pérez, Christine K. Tarr-Attia, Bondey Breeze-Barry, Adelaida Sarukhan, Dawoh Peter Lansana, Ana Meyer García-Sípido, Anna Rosés, María Maixenchs, Quique Bassat and Alfredo Mayor

    Citation: Malaria Journal 2018 17:132

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  31. Content type: Short report

    The ever-increasing speed and scope of human mobility by international air travel has led to a global transport network for infectious diseases with the potential to introduce pathogens into non-endemic areas,...

    Authors: Greg Martin and Mairin Boland

    Citation: Globalization and Health 2018 14:28

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  32. Content type: Research article

    Little is understood of Ebola virus disease (EVD) transmission dynamics and community compliance with control measures over time. Understanding these interactions is essential if interventions are to be effect...

    Authors: Grazia Caleo, Jennifer Duncombe, Freya Jephcott, Kamalini Lokuge, Clair Mills, Evita Looijen, Fivi Theoharaki, Ronald Kremer, Karline Kleijer, James Squire, Manjo Lamin, Beverley Stringer, Helen A. Weiss, Daniel Culli, Gian Luca Di Tanna and Jane Greig

    Citation: BMC Public Health 2018 18:248

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  33. Content type: Research

    Ebolavirus (EBOV) is responsible for one of the most fatal diseases encountered by mankind. Cellular T-cell responses have been implicated to be important in providing protection against the virus. Antigenic vari...

    Authors: Wan Ching Lim and Asif M. Khan

    Citation: BMC Genomics 2018 19(Suppl 1):42

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    This article is part of a Supplement: Volume 19 Supplement 1

  34. Content type: Research article

    The Ebola outbreak in West-Africa triggered risk communication activities to promote adequate preventive behaviour in the Netherlands. Our study investigated the level of knowledge, perceptions, and media use ...

    Authors: Lianne G. C. Schol, Madelief Mollers, Corien M. Swaan, Desirée J. M. A. Beaujean, Albert Wong and Aura Timen

    Citation: BMC Infectious Diseases 2018 18:18

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  35. Content type: Research article

    As part of its response to the 2014 Ebola outbreak in west Africa, the United Kingdom (UK) government established an Ebola treatment unit in Sierra Leone, staffed by military personnel. Little is known about t...

    Authors: Heather Draper and Simon Jenkins

    Citation: BMC Medical Ethics 2017 18:77

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  36. Content type: Research

    For 30 years, women have sought equal opportunity to be included in trials so that drugs are equitably studied in women as well as men; regulatory guidelines have changed accordingly. Pregnant women, however, ...

    Authors: Melba F. Gomes, Vânia de la Fuente-Núñez, Abha Saxena and Annette C. Kuesel

    Citation: Reproductive Health 2017 14(Suppl 3):172

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    This article is part of a Supplement: Volume 14 Supplement 3

  37. Content type: Research

    During the 2014–2016 Ebola epidemic, Médecins Sans Frontières (MSF) treated Ebola-positive pregnant women in its Ebola Treatment Centers (ETCs). For pregnant women with confirmed Ebola virus disease, inclusion...

    Authors: Séverine Caluwaerts

    Citation: Reproductive Health 2017 14(Suppl 3):157

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    This article is part of a Supplement: Volume 14 Supplement 3

  38. Content type: Research article

    The outbreak of the Ebola virus disease (EVD) in 2014 led to massive dropouts in HIV care in Guinea. Meanwhile, Médecins Sans Frontières (MSF) was implementing a six-monthly appointment spacing approach adapte...

    Authors: Cavin Epie Bekolo, Abdourahimi Diallo, Mit Philips, Joseph-Desire Yuma, Letizia Di Stefano, Stéphanie Drèze, Jerome Mouton, Youssouf Koita and Ousseni W. Tiomtore

    Citation: BMC Infectious Diseases 2017 17:766

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  39. Content type: Opinion

    The 2014–2016 Ebola crisis in West Africa had approximately eight times as many reported deaths as the sum of all previous Ebola outbreaks. The outbreak magnitude and occurrence of multiple Ebola cases in at l...

    Authors: Eduardo A. Undurraga, Cristina Carias, Martin I. Meltzer and Emily B. Kahn

    Citation: Infectious Diseases of Poverty 2017 6:159

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  40. Content type: Scoping Review

    In the three decades since the first reported case of Ebola virus, most known index cases have been consistently traced to the hunting of “bush meat”, and women have consistently recorded relatively high fatal...

    Authors: Miriam N. Nkangu, Oluwasayo A. Olatunde and Sanni Yaya

    Citation: Infectious Diseases of Poverty 2017 6:135

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  41. Content type: Case report

    During the 2013–2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA.

    Authors: Emanuele Nicastri, Antonio Brucato, Nicola Petrosillo, Gianluigi Biava, Timothy M. Uyeki and Giuseppe Ippolito

    Citation: BMC Infectious Diseases 2017 17:597

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  42. Content type: Research

    Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks. Four Ebolavirus species cause severe disease ass...

    Authors: Morena Pappalardo, Francesca Collu, James Macpherson, Martin Michaelis, Franca Fraternali and Mark N. Wass

    Citation: BMC Genomics 2017 18(Suppl 5):566

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    This article is part of a Supplement: Volume 18 Supplement 5

  43. Content type: Research article

    Communication is of paramount importance in responding to health crises. We studied the media messages put forth by different stakeholders in two Ebola vaccine trials that became controversial in Ghana. These ...

    Authors: Per Egil Kummervold, William S. Schulz, Elizabeth Smout, Luis Fernandez-Luque and Heidi J. Larson

    Citation: BMC Public Health 2017 17:642

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  44. Content type: Research article

    Across low-income settings, community volunteers and health committee members support the formal health system - both routinely and amid emergencies - by engaging in health services such as referrals and healt...

    Authors: Shannon A. McMahon, Lara S. Ho, Kerry Scott, Hannah Brown, Laura Miller, Ruwan Ratnayake and Rashid Ansumana

    Citation: BMC Health Services Research 2017 17:495

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  45. Content type: Introduction

    West Africa was the focus of global attention during the Ebola virus disease outbreak, when systemic health system weaknesses compounded a serious emergency and complicated response efforts. Following the cris...

    Authors: Sue Godt, Sharmila Mhatre and Anne-Marie Schryer-Roy

    Citation: Health Research Policy and Systems 2017 15(Suppl 1):52

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    This article is part of a Supplement: Volume 15 Supplement 1

  46. Content type: Debate

    Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organizatio...

    Authors: Emilie Alirol, Annette C. Kuesel, Maria Magdalena Guraiib, Vânia de la Fuente-Núñez, Abha Saxena and Melba F. Gomes

    Citation: BMC Medical Ethics 2017 18:43

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    The Erratum to this article has been published in BMC Medical Ethics 2017 18:45

  47. Content type: Research article

    The recent Ebola Virus Disease (EVD) epidemic that hit some countries in West Africa underscores the need to train front line high-risk health workers on disease prevention skills. Although Ghana did not recor...

    Authors: Augustina Angelina Annan, Denis Dekugmen Yar, Michael Owusu, Eno Akua Biney, Paa Kobina Forson, Portia Boakye Okyere, Akosua Adumea Gyimah and Ellis Owusu-Dabo

    Citation: BMC Public Health 2017 17:546

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  48. Content type: Research article

    The outbreak of the Ebola virus disease (EVD) in West Africa in December 2013 was the largest Ebola outbreak in history. This study aimed to measure the underlying contextual and psychosocial factors of intent...

    Authors: Anna E. Gamma, Jurgita Slekiene, Gregor von Medeazza, Fredrik Asplund, Placido Cardoso and Hans-Joachim Mosler

    Citation: BMC Public Health 2017 17:446

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