Fabrice Lucien-Matteoni, PhD, Mayo Clinic, United States of America
Clinical Proteomics is calling for submissions to our Collection on Extracellular Vesicles (EVs) and Proteomics. This Collection aims to highlight the latest advancements in EV proteomics, showcasing innovative research utilizing cutting-edge proteomic techniques including mass spectrometry, proximity extension assays and protein microarrays.
Extracellular vesicles (EVs) are small membrane-bound particles secreted by cells facilitating intercellular communication. Utilizing advanced mass spectrometry techniques, researchers are conducting comprehensive analyses of both surface and vesicular proteome of EVs. The comprehensive study of the protein composition of EVs can unveil novel biological insights on the multifaceted roles of EVs in intercellular communication and their impact on physiological and pathological processes. In addition, EV proteomics can reveal novel liquid biomarkers and therapeutic targets, thereby improving the management and treatment of human diseases.
In biofluids, tissue-derived EVs are in very low abundance compared to blood-derived EVs, therefore the proteomic study of tissue-derived EVs requires rigorous control of pre-analytical procedures and reproducible analytical approaches.
This Collection in Clinical Proteomics aims to highlight the latest advancements in EV proteomics, showcasing innovative research utilizing cutting-edge proteomic techniques including mass spectrometry, proximity extension assays and protein microarrays. We encourage submissions leveraging proteomics to understand the role of EVs in cellular communication and their clinical value as disease biomarkers, including but not limited to:
• Methodological advancements in EV proteomics
• Optimization and standardization of pre-analytical factors for EV proteomics
• Proteomics of EVs from biofluids in normal conditions and diseases
• Biomarker discovery and validation
• Mechanisms of EV-mediated intercellular communication
• EVs in immune modulation, disease development and progression
• EV biogenesis and cargo sorting
There are currently no articles in this collection.
This Collection welcomes submissions of original research and review articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.
Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Extracellular Vesicles and Proteomics" under the “Details” tab during the submission stage.
Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.
The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.