Guest Editors:
Orazio Fortunato: Tumor Genomic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
Irina Matei: Weill Cornell Medicine, USA
Chunlin Ou: Xiangya Hospital, Central South University, China
BMC Cancer has published this Collection on the dynamic interaction between cancer cells and the tumour microenvironment mediated by the bi-directional release and uptake of extracellular vesicles.
Orazio Fortunato: Tumor Genomic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy
Orazio Fortunato, PhD, Tumor Genomic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan. Due to his expertise in biomarkers, he is involved directly in the development and analyses of circulating extracellular vesicles as biomarkers in plasma of lung cancer patients. He had given a major contribution to the study of miRNAs, particularly focusing on those miRNAs de-regulated in lung tumors and plasma samples. Recently, his research is focused on the functional role of extracellular vesicles in the development and progression of lung cancer. His current interest also includes the identification of extracellular vesicles as biomarkers of response to immunotherapy in cancer patients.
Irina Matei: Weill Cornell Medicine, USAIrina Matei is an Assistant Professor of Immunology Research for Weill Cornell Medicine. She has expertise in cancer metastasis and exosome biology and combines innovative basic tumor biology research with translational studies, relating basic discoveries to advances in patient treatments. Her current research focuses on the crosstalk between tumor cells and the local and distant tumor microenvironment via exosomes. Specifically, she is interested in deciphering the role of exosomes in mediating the crosstalk within and with the immune system in normal physiology, cancer and autoimmunity. Dr. Matei’s current work is focused on the mechanisms through which exosomes coax the immune system to contribute to malignant progression.
Chunlin Ou: Xiangya Hospital, Central South University, China
Chunlin Ou is a Professor for Xiangya Hospital, Central South University, working for the department of Pathology. His researches focus on the molecular targeted therapy for human cancers, which mainly involve: the role of Hippo/YAP signaling pathway in targeted therapy of cancers; exploring the regulatory mechanism of extracellular vesicles-derived non-coding RNAs in cancers; searching novel biomarkers and drug targets for the early diagnosis and therapy of cancers; and clinical application of mRNA vaccine in cancers. Professor Ou is also an Editorial Board member of BMC Cancer.
Over the last few decades it has become clear that the cross-talk between neoplastic cells and the tumour microenvironment, comprising resident and infiltrating host cells, extracellular matrix proteins and secreted factors, plays a key role in tumour progression and therapeutic resistance. The dynamic interaction between cancer cells and the tumour microenvironment can be mediated by the bi-directional release and uptake of extracellular vesicles. Defined as lipid bilayer enclosed vesicles found in several biological fluids, extracellular vesicles are currently investigated for their ability to carry and deliver, at both short and long distances, several bioactive molecules, including nucleic acids, lipids and membrane-bound and cytosolic proteins, which could potentially influence many aspects of cancer progression.
Liquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesi...
Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers t...
Gastric cancer (GC) is one of the malignant tumors with the highest mortality worldwide. Our previous studies have revealed that LINC00691 is up-regulated in serum of GC patients as a novel potential biomarker...
The optimal treatment for multiple brain metastases has been recently controversially discussed.This study was aimed to explore the feasibility of Hippocampus-Avoidance Whole-Brain Radiotherapy plus a simultan...
Cancer cells release heterogeneous populations of extracellular vesicles (EVs) that transmit aggressive phenotypic traits to recipient cells. We aimed to establish if the heterogenous EVs population or a sub-p...
Recent reports have demonstrated that the entire mitochondrial genome can be secreted in extracellular vesicles (EVs), but the biological attributes of this cell-free mitochondrial DNA (mtDNA) remain insuffici...
Small extracellular vesicles (sEVs) have great potential as new biomarkers in liquid biopsy. However, due to the limitations of sEVs extraction and component analysis procedures, further clinical applications ...
Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcino...
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Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.
The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.