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EUROTAU: Reflections on the Status Quo

​​​​​​​Editors: Werner Paulus and Johannes Attems

Acta Neuropathologica Communications is pleased to present a series of articles from the first and second EUROTAU meetings in Europe.

EUROTAU provides a forum for promoting ambitious, innovative, multi-national and multi-disciplinary collaborative research projects, that: i) combine experimental approaches from fundamental, pre-clinical and/or clinical with computational approaches; ii) perform network analyses in different Tauopathies to elucidate the underlying mechanisms that are common as well as those that are different between them, and iii) will add value to existing research by analyzing diseases across traditional clinical boundaries, thereby gaining deeper understanding of the patho-physiological mechanisms of these disorders.  

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The editors declare that they have no competing interests.

Publication is ongoing.

  1. Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in th...

    Authors: Suzanne Lam, Anne-Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, Jean-Luc Picq, Luc Buée, Charles Duyckaerts, Stéphane Haïk and Marc Dhenain
    Citation: Acta Neuropathologica Communications 2022 10:112
  2. Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filam...

    Authors: Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée and Isabelle Landrieu
    Citation: Acta Neuropathologica Communications 2019 7:31
  3. Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer’s disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel ...

    Authors: Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor G. Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis D Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee and Norbert Zilka
    Citation: Acta Neuropathologica Communications 2019 7:22
  4. Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer’s disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus...

    Authors: Mahmoud B. Maina, Laura J. Bailey, Sherin Wagih, Luca Biasetti, Saskia J. Pollack, James P. Quinn, Julian R. Thorpe, Aidan J. Doherty and Louise C. Serpell
    Citation: Acta Neuropathologica Communications 2018 6:70
  5. Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propaga...

    Authors: Amrit Mudher, Morvane Colin, Simon Dujardin, Miguel Medina, Ilse Dewachter, Seyedeh Maryam Alavi Naini, Eva-Maria Mandelkow, Eckhard Mandelkow, Luc Buée, Michel Goedert and Jean-Pierre Brion
    Citation: Acta Neuropathologica Communications 2017 5:99
  6. Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological cons...

    Authors: Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher and Luc Buee
    Citation: Acta Neuropathologica Communications 2017 5:91
  7. Microtubule-associated protein tau aggregates constitute the characteristic neuropathological features of several neurodegenerative diseases grouped under the name of tauopathies. It is now clear that the proc...

    Authors: Marta Sidoryk-Wegrzynowicz, Yannick N. Gerber, Miriam Ries, Magdalena Sastre, Aviva M. Tolkovsky and Maria Grazia Spillantini
    Citation: Acta Neuropathologica Communications 2017 5:89