Epigenetic reprogramming during development coordinates crucial changes in gene expression patterns without altering DNA sequences. This process, essential for cellular differentiation and tissue specialization, involves dynamic modifications to chromatin structure, including DNA methylation and histone modifications. Early developmental stages witness extensive erasure of epigenetic marks followed by establishment of lineage-specific patterns. Such reprogramming ensures cellular plasticity while generating embryonic gene expression profiles essential for proper development. Dysregulation in this delicate balance can lead to developmental disorders and diseases. Understanding the intricate network of epigenetic modifications in reprogramming holds significant promise for unraveling developmental processes and therapeutic interventions targeting covalent epigenetic marks.
We invite researchers from diverse backgrounds to submit original research articles and review papers that investigate the dynamics of epigenetic reprogramming during development.
Topics of interest include but are not limited to:
• Mechanisms of DNA methylation and histone modification during cellular differentiation
• Environmental influences on epigenetic reprogramming
• Role of non-coding RNAs in developmental epigenetics
• Epigenetic regulation of stem cell pluripotency and differentiation
• Implications of epigenetic dysregulation in developmental disorders and diseases