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Epigenetic Mechanisms in Developmental Origin of Health and Disease

Edited by:
Rene Cortese:
University of Missouri, USA
Albert Hsu: University of Missouri, USA

Submission Status: Open   |   Submission Deadline: 30 April 2024

Epigenetics Communications is calling for submissions to our Collection on "Epigenetic Mechanisms in Developmental Origin of Health and Disease".

Image credit: Syda Productions /

About the collection

The Developmental Origins of Health and Disease (DOHaD) theory states that exposure to environmental factors during fetal development will have short- and long-term consequences in an individual’s health. The Barker’s hypothesis, also referred to as “thrifty phenotype hypothesis”, proposes that poor nutrition during development produces permanent changes in the fetus leading to poor fetal and infant growth and subsequent metabolic syndromes later in life. These earlier observations suggested that early environmental exposures, such as gestational hyperglycemia, maternal obesity and overfeeding during pregnancy, alter the programming of genes resulting in a long-term imprint on gene expression that lasts into adulthood. These long-term effects are now believed to be mediated by epigenetic changes and evidence supportive of such assumptions is emerging. Hence, studies of gestational and neonatal diseases provide an ideal setup to investigate the epigenetic plasticity during development, the interactions with other factors - such as nutrition, microbiome colonization, etc.-, and how such interactions influence the human phenotype postnatally and the epigenetic mechanisms regulating them.

This Collection is dedicated to highlight the most recent advances in epigenetic research pertaining developmental origins of health and disease, including mechanistic, targeted, and genome-wide epigenetic analyses. As such, we invite submission of manuscripts encompassing any studies that are focused on epigenetics in DOHaD to increase our understanding of developmental epigenetic plasticity, how it conditions health postnatally, and the possible translation of this knowledge into clinical practice.

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original Research Articles and Reviews. 

Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Epigenetic Mechanisms in Developmental Origin of Health and Disease" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.