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Hot topics in headache and pain from the EHF-SAS

Edited by: Paolo Martelletti 

This collection of articles results from the tight collaboration between the European Headache Federation (EHF) and its Official Journal, The Journal of Headache and Pain.  

The educational aim of EHF, its own School of Advanced Studies (EHF-SAS), provides for nurturing talented young researchers in the headache area. Each Meeting of the EHF-SAS ends its path with the preparation of a review on special topics to be submitted for regular peer-review. EHF provides economical support for the related APCs. In such way we think that the positive loop might be maintained and attract more and more young researchers. The activity of the EHF-SAS is academically based in Sapienza University of Rome, but its mission foresees also EHF-SAS Meetings hosted by the EHF Federated Societies in their own countries.

This collection of articles has been sponsored by the EHF. Articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief. 

  1. Resting-state functional connectivity (FC) MRI has widely been used to understand migraine pathophysiology and to identify an imaging marker of the disorder. Here, we review what we have learned from FC studies.

    Authors: Kirill Skorobogatykh, Willem Sebastiaan van Hoogstraten, Diana Degan, Anastasia Prischepa, Anastasya Savitskaya, Biondo Michela Ileen, Enrico Bentivegna, Iaroslav Skiba, Laura D’Acunto, Livia Ferri, Simona Sacco, Jakob Møller Hansen and Faisal Mohammad Amin

    Citation: The Journal of Headache and Pain 2019 20:108

    Content type: Review article

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  2. The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in...

    Authors: Soodeh Razeghi Jahromi, Zeinab Ghorbani, Paolo Martelletti, Christian Lampl and Mansoureh Togha

    Citation: The Journal of Headache and Pain 2019 20:106

    Content type: Review article

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  3. Headache is very often the cause for seeking an emergency department (ED). However, less is known about the different diagnosis of headache disorders in the ED, their management and treatment. The aim of this ...

    Authors: Alberto Doretti, Irina Shestaritc, Daniela Ungaro, John-Ih Lee, Loukas Lymperopoulos, Lili Kokoti, Martina Guglielmetti, Dimos Dimitrios Mitsikostas and Christian Lampl

    Citation: The Journal of Headache and Pain 2019 20:100

    Content type: Research article

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  4. Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migrain...

    Authors: Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello and Gianluca Serafini

    Citation: The Journal of Headache and Pain 2019 20:51

    Content type: Review article

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  5. Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors ...

    Authors: Valentina Favoni, Luca Giani, Linda Al-Hassany, Gian Maria Asioli, Calogera Butera, Irene de Boer, Martina Guglielmetti, Chrysoula Koniari, Theodoros Mavridis, Marge Vaikjärv, Iris Verhagen, Angela Verzina, Bart Zick, Paolo Martelletti and Simona Sacco

    Citation: The Journal of Headache and Pain 2019 20:27

    Content type: Review article

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  6. The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and fem...

    Authors: Zoë Delaruelle, Tatiana A. Ivanova, Sabrina Khan, Andrea Negro, Raffaele Ornello, Bianca Raffaelli, Alberto Terrin, Dimos D. Mitsikostas and Uwe Reuter

    Citation: The Journal of Headache and Pain 2018 19:117

    Content type: Review article

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  7. Primary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous...

    Authors: D. García-Azorin, N. Yamani, L. M. Messina, I. Peeters, M. Ferrili, D. Ovchinnikov, M. L. Speranza, V. Marini, A. Negro, S. Benemei and M. Barloese

    Citation: The Journal of Headache and Pain 2018 19:90

    Content type: Research article

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    The Correction to this article has been published in The Journal of Headache and Pain 2019 20:14

  8. Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related...

    Authors: Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina and Christian Lampl

    Citation: The Journal of Headache and Pain 2018 19:89

    Content type: Review

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  9. There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role ...

    Authors: Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K. Czapinska-Ciepiela, Daponte D. Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky and Mattias Linde

    Citation: The Journal of Headache and Pain 2018 19:83

    Content type: Review article

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  10. Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent i...

    Authors: Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink and Lars Edvinsson

    Citation: The Journal of Headache and Pain 2018 19:64

    Content type: Review article

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  11. Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to h...

    Authors: Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2018 19:50

    Content type: Review article

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  12. This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

    Authors: A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

    Citation: The Journal of Headache and Pain 2017 18:106

    Content type: Review article

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  13. The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

    Authors: Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

    Citation: The Journal of Headache and Pain 2017 18:103

    Content type: Review article

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  14. Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Authors: Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink

    Citation: The Journal of Headache and Pain 2017 18:96

    Content type: Review article

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