The Dll4/Notch pathway as a therapeutic target in tumors
Edited by Jan Kitajewski
This Vascular Cell review series, developed by leaders in pharmaceutical and academic cancer research, presents an update on efforts to block tumor growth by targeting the Dll4/Notch pathway. This pathway is active during tumor angiogenesis and in cancer stem cells. The excitement about the effective targeting of tumors using this approach and the challenge of minimizing adverse responses are key points of discussion.