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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. However, systematic reviews of the registered clinical trials are still lacking. T...

    Authors: Rui-fang Zhu, Yu-lu Gao, Sue-Ho Robert, Jin-ping Gao, Shi-gui Yang and Chang-tai Zhu
    Citation: Journal of Translational Medicine 2020 18:274
  2. Healthy childhood development is fostered through sufficient physical activity (PA; including time outdoors), limiting sedentary behaviours (SB), and adequate sleep; collectively known as movement behaviours. ...

    Authors: Sarah A. Moore, Guy Faulkner, Ryan E. Rhodes, Mariana Brussoni, Tala Chulak-Bozzer, Leah J. Ferguson, Raktim Mitra, Norm O’Reilly, John C. Spence, Leigh M. Vanderloo and Mark S. Tremblay
    Citation: International Journal of Behavioral Nutrition and Physical Activity 2020 17:85
  3. The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana...

    Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu
    Citation: Journal of Translational Medicine 2020 18:270
  4. Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of deat...

    Authors: Wenjing Ye, Guoxi Chen, Xiaopan Li, Xing Lan, Chen Ji, Min Hou, Di Zhang, Guangwang Zeng, Yaling Wang, Cheng Xu, Weiwei Lu, Ruolin Cui, Yuyang Cai, Hai Huang and Ling Yang
    Citation: Respiratory Research 2020 21:169
  5. The primary objectives of the study are:

    Authors: Raquel González, Laura García-Otero, Clara Pons-Duran, Elena Marbán-Castro, Anna Goncé, Elisa Llurba, Maria del Mar Gil, Miguel Ángel Rodríguez-Zambrano, Haily Chen, Máximo Ramírez, Azucena Bardají and Clara Menendez
    Citation: Trials 2020 21:607
  6. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection beca...

    Authors: Shi-Hui Song, Tie-Long Chen, Li-Ping Deng, Yong-Xi Zhang, Ping-Zheng Mo, Shi-Cheng Gao, Wen-Jia Hu, Yong Xiong and Zhi-Yong Ma
    Citation: Infectious Diseases of Poverty 2020 9:82
  7. This editorial describes why surge planning in the community must account for potential infection outbreaks in jails and prisons, and why incarcerated people and those in contact with them, including over 450,...

    Authors: Oluwadamilola T. Oladeru, Nguyen-Toan Tran, Tala Al-Rousan, Brie Williams and Nickolas Zaller
    Citation: Health & Justice 2020 8:17
  8. There is currently considerable international debate around school closures/openings and the role of children in the transmission of coronavirus disease 2019 (COVID-19). Whilst evidence suggests that children ...

    Authors: Darren J. Gray, Johanna Kurscheid, Mary Lorraine Mationg, Gail M. Williams, Catherine Gordon, Matthew Kelly, Kinley Wangdi and Donald P. McManus
    Citation: Infectious Diseases of Poverty 2020 9:81
  9. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci
    Citation: Clinical and Molecular Allergy 2020 18:12
  10. In December 2019, 27 cases of pneumonia, of unknown cause, were identified in the province of Hubei (China). The WHO declared the situation as a Public Health Emergency of International Concern, and it was fin...

    Authors: Juan Jose Gonzalez-Gerez, Carlos Bernal-Utrera, Ernesto Anarte-Lazo, Jose Antonio Garcia-Vidal, Jose Martin Botella-Rico and Cleofas Rodriguez-Blanco
    Citation: Trials 2020 21:588
  11. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze
    Citation: Journal of Translational Medicine 2020 18:261
  12. This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

    Authors: Yiying Huang, Cuiyan Tan, Jian Wu, Meizhu Chen, Zhenguo Wang, Liyun Luo, Xiaorong Zhou, Xinran Liu, Xiaoling Huang, Shican Yuan, Chaolin Chen, Fen Gao, Jin Huang, Hong Shan and Jing Liu
    Citation: Respiratory Research 2020 21:163
  13. It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respi...

    Authors: Shao-Hang Cai, Wei Liao, Shu-Wei Chen, Li-Li Liu, Si-Yao Liu and Zhi-Dan Zheng
    Citation: Infectious Diseases of Poverty 2020 9:80
  14. Coronavirus disease 2019 (COVID-19) is now a global public threat. Given the pandemic of COVID-19, the economic impact of COVID-19 is essential to add value to the policy-making process. We retrospectively con...

    Authors: Xue-Zheng Li, Feng Jin, Jian-Guo Zhang, Yun-Feng Deng, Wei Shu, Jing-Min Qin, Xin Ma and Yu Pang
    Citation: Infectious Diseases of Poverty 2020 9:78
  15. In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated.

    Authors: Abolghasem Allahyari, Hossein Rahimi, Majid Khadem-Rezaiyan, Zahra Mozaheb, Mohsen Seddigh-Shamsi, Alireza Bary, Mostafa Kamandi, Sajad Ataei Azimi, Saeed Eslami HasanAbadi, Alireza Noferesti, Somayeh Sadat Shariatmaghani, Houshang Rafatpanah, Shohreh Khatami, Afshin Jabbar Imani, Hassan Mortazi and Mohammad Moeini Nodeh
    Citation: Trials 2020 21:575

    The Update to this article has been published in Trials 2021 22:349

  16. The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to h...

    Authors: Efrat Shadmi, Yingyao Chen, Inês Dourado, Inbal Faran-Perach, John Furler, Peter Hangoma, Piya Hanvoravongchai, Claudia Obando, Varduhi Petrosyan, Krishna D. Rao, Ana Lorena Ruano, Leiyu Shi, Luis Eugenio de Souza, Sivan Spitzer-Shohat, Elizabeth Sturgiss, Rapeepong Suphanchaimat…
    Citation: International Journal for Equity in Health 2020 19:104
  17. The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease...

    Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman
    Citation: Journal of Translational Medicine 2020 18:257
  18. Currently, coronavirus disease 2019 (COVID-19) is continuously and rapidly circulating, causing heavy damage on public health. No effective antiviral treatment has been proved thus far. Traditional Chinese med...

    Authors: Bangjiang Fang, Wen Zhang, Xinxin Wu, Tingrong Huang, Huacheng Li, You Zheng, Jinhua Che, Shuting Sun, Chao Jiang, Shuang Zhou and Jun Feng
    Citation: Trials 2020 21:568
  19. During the COVID-19 pandemic, as a large city located in Southwest China, Chengdu was mainly affected by imported cases. For a psychiatric hospital, the enclosed management model, the crowded wards and the unc...

    Authors: Jiajia Chen, Maoxiang Xiong, Zongling He, Wen Shi, Yuchuan Yue and Manxi He
    Citation: Globalization and Health 2020 16:53
  20. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella
    Citation: Journal of Translational Medicine 2020 18:251
  21. As COVID-19 makes its way around the globe, each nation must decide when and how to respond. Yet many knowledge gaps persist, and many countries lack the capacity to develop complex models to assess risk and r...

    Authors: Lei Zhou, Jiang-Mei Liu, Xiao-Ping Dong, Jennifer M. McGoogan and Zun-You Wu
    Citation: Infectious Diseases of Poverty 2020 9:76
  22. Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

    Authors: Changzhi Zhou, Zhe Huang, Weijun Tan, Xueying Li, Wen Yin, Yang Xiao, Zhaowu Tao, Shuang Geng and Yi Hu
    Citation: Respiratory Research 2020 21:157
  23. Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

    Authors: Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough and Irfan Rahman
    Citation: Respiratory Research 2020 21:154
  24. Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

    Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti
    Citation: Clinical and Translational Allergy 2020 10:23
  25. At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with disastrous consequences for people of all countr...

    Authors: Xiaofeng Ruan, Peng Du, Kang Zhao, Jucun Huang, Hongmei Xia, Dan Dai, Shu Huang, Xiang Cui, Liming Liu and Jianjun Zhang
    Citation: Chinese Medicine 2020 15:62
  26. A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Cov...

    Authors: Celestino Sardu, Giuseppe Gargiulo, Giovanni Esposito, Giuseppe Paolisso and Raffaele Marfella
    Citation: Cardiovascular Diabetology 2020 19:76
  27. The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and...

    Authors: Pradeesh Sivapalan, Charlotte Suppli Ulrik, Rasmus Dahlin Bojesen, Therese Sophie Lapperre, Josefin Viktoria Eklöf, Kjell Erik Julius Håkansson, Andrea Browatzki, Casper Tidemansen, Jon Torgny Wilcke, Julie Janner, Vibeke Gottlieb, Howraman Meteran, Celeste Porsbjerg, Birgitte Lindegaard Madsen, Mia Moberg, Lars Pedersen…
    Citation: Trials 2020 21:513

    The Update to this article has been published in Trials 2020 21:867

  28. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito
    Citation: Journal of Translational Medicine 2020 18:233
  29. The purpose of this study is to report the clinical features and outcomes of Black/African American (AA) and Latino Hispanic patients with Coronavirus disease 2019 (COVID-19) hospitalized in an inter-city hosp...

    Authors: Alexis K. Okoh, Christoph Sossou, Neha S. Dangayach, Sherin Meledathu, Oluwakemi Phillips, Corinne Raczek, Michael Patti, Nathan Kang, Sameer A. Hirji, Charles Cathcart, Christian Engell, Marc Cohen, Sandhya Nagarakanti, Eliahu Bishburg and Harpreet S. Grewal
    Citation: International Journal for Equity in Health 2020 19:93
  30. Although research on the effects of comorbidities on coronavirus disease 2019 (COVID-19) patients is increasing, the risk of cancer history has not been evaluated for the mortality of patients with COVID-19.

    Authors: Yifan Meng, Wanrong Lu, Ensong Guo, Jia Liu, Bin Yang, Ping Wu, Shitong Lin, Ting Peng, Yu Fu, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Funian Lu…
    Citation: Journal of Hematology & Oncology 2020 13:75
  31. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo
    Citation: Journal of Translational Medicine 2020 18:229
  32. SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that has impacted many aspects of human society. Several issues concerning the origin, time of introduction to humans, evolutionary p...

    Authors: Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen and Hurng-Yi Wang
    Citation: Journal of Biomedical Science 2020 27:73
  33. On December 31, 2019, the World Health Organization was alerted to the occurrence of cases of pneumonia in Wuhan, Hubei Province, China, that were caused by an unknown virus, which was later identified as a co...

    Authors: Soyoung Kim, Sunhwa Choi, Youngsuk Ko, Moran Ki and Eunok Jung
    Citation: Theoretical Biology and Medical Modelling 2020 17:9
  34. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2020 27:72
  35. Primary Objective

    Authors: Ruanne V. Barnabas, Elizabeth Brown, Anna Bershteyn, R. Scott Miller, Mark Wener, Connie Celum, Anna Wald, Helen Chu, David Wesche and Jared M. Baeten
    Citation: Trials 2020 21:475
  36. COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effe...

    Authors: Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo and Emanuele Marra
    Citation: Journal of Translational Medicine 2020 18:222
  37. The COVID-19 pandemic has spread rapidly since the first case notification of the WHO in December 2019. Lacking an effective treatment, countries have implemented non-pharmaceutical interventions including soc...

    Authors: Safia S. Jiwani and Daniel A. Antiporta
    Citation: International Journal for Equity in Health 2020 19:82
  38. Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be f...

    Authors: Victoria Brazil, Belinda Lowe, Leanne Ryan, Rachel Bourke, Clare Scott, Simone Myers, Hellen Kaneko, Jane Schweitzer and Brenton Shanahan
    Citation: Advances in Simulation 2020 5:9
  39. Use of simulation to ensure an organization is ready for significant events, like COVID-19 pandemic, has shifted from a “backburner” training tool to a “first choice” strategy for ensuring individual, team, an...

    Authors: Ryan Brydges, Douglas M. Campbell, Lindsay Beavers, Nazanin Khodadoust, Paula Iantomasi, Kristen Sampson, Alberto Goffi, Filipe N. Caparica Santos and Andrew Petrosoniak
    Citation: Advances in Simulation 2020 5:8
  40. The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide. Ironically, this coincides with an immed...

    Authors: Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza and Andre Moreira
    Citation: Journal of Translational Medicine 2020 18:219

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:240

  41. In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unk...

    Authors: Jehun Song, Seongmin Kang, Seung Won Choi, Kwang Won Seo, Sunggun Lee, Min Wook So and Doo-Ho Lim
    Citation: Rheumatology International 2020 40:4584