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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. The aim of this study is to assess the efficacy of the use of pre-exposure prophylaxis (PrEP) with hydroxychloroquine against placebo in healthcare workers with high risk of severe acute respiratory syndrome c...

    Authors: Berta Grau-Pujol, Daniel Camprubí, Helena Marti-Soler, Marc Fernández-Pardos, Caterina Guinovart and Jose Muñoz
    Citation: Trials 2020 21:688
    Content type: Letter Published on:

  2. Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investiga...

    Authors: Li-Da Chen, Zhen-Yu Zhang, Xiao-Jie Wei, Yu-Qing Cai, Weng-Zhen Yao, Ming-Hui Wang, Qiu-Fen Huang and Xiao-Bin Zhang
    Citation: Respiratory Research 2020 21:201
    Content type: Research Published on:

    The Letter to the Editor to this article has been published in Respiratory Research 2020 21:315

  3. By mid-May 2020, there were over 1.5 million cases of (SARS-CoV-2) or COVID-19 across the U.S. with new confirmed cases continuing to rise following the re-opening of most states. Prior studies have focused ma...

    Authors: Yelena Rozenfeld, Jennifer Beam, Haley Maier, Whitney Haggerson, Karen Boudreau, Jamie Carlson and Rhonda Medows
    Citation: International Journal for Equity in Health 2020 19:126
    Content type: Research Published on:

  4. Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

    Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…
    Citation: The Journal of Headache and Pain 2020 21:94
    Content type: Research article Published on:

  5. The COVID pandemic has been devastating for not only its direct impact on lives, physical health, socio-economic status of individuals, but also for its impact on mental health. Some individuals are affected p...

    Authors: Pallab K. Maulik, Graham Thornicroft and Shekhar Saxena
    Citation: International Journal of Mental Health Systems 2020 14:57
    Content type: Debate Published on:

  6. COVID-19 has taken the world by surprise; even the most sophisticated healthcare systems have been unable to cope with the volume of patients and lack of resources. Yet the gradual spread of the virus in Leban...

    Authors: Zavi Lakissian, Rami Sabouneh, Rida Zeineddine, Joe Fayad, Rim Banat and Rana Sharara-Chami
    Citation: Advances in Simulation 2020 5:15
    Content type: Research Published on:

  7. The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet wi...

    Authors: Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt and Bart N. Lambrecht
    Citation: Respiratory Research 2020 21:198
    Content type: Review Published on:

    The Letter to the Editor to this article has been published in Respiratory Research 2021 22:12

  9. The outbreak of 2019 coronavirus disease (COVID-19) could increase the risk of depression. However, epidemiological data on outbreak-associated depressive morbidity of female adolescents are not available. Thi...

    Authors: Jiaojiao Zhou, Xiaofei Yuan, Han Qi, Rui Liu, Yaqiong Li, Huanhuan Huang, Xu Chen and Gang Wang
    Citation: Globalization and Health 2020 16:69
    Content type: Research Published on:

  10. In an effort to prevent infants being infected with SARS-CoV-2, some governments, professional organisations, and health facilities are instituting policies that isolate newborns from their mothers and otherwi...

    Authors: Karleen Gribble, Roger Mathisen, Mija-tesse Ververs and Anna Coutsoudis
    Citation: International Breastfeeding Journal 2020 15:67
    Content type: Commentary Published on:

  11. From December 25, 2019 to January 31, 2020, 33 cases of the coronavirus disease 2019 (COVID-19) were identified in the Department of Respiratory and Critical Care Medicine of Zhongnan Hospital of Wuhan Univers...

    Authors: Gu-Qin Zhang, Hua-Qin Pan, Xing-Xing Hu, Shao-Jun He, Yi-Fei Chen, Chao-Jie Wei, Lan Ni, Li-Ping Zhang, Zhen-Shun Cheng and Jiong Yang
    Citation: Infectious Diseases of Poverty 2020 9:104
    Content type: Short Report Published on:

  12. Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restric...

    Authors: Kun Xiao, Fei Hou, Xiuyu Huang, Binbin Li, Zhi Rong Qian and Lixin Xie
    Citation: Stem Cell Research & Therapy 2020 11:305
    Content type: Review Published on:

  13. Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.

    Authors: Xiaofan Lu, Liyun Jiang, Taige Chen, Yang Wang, Bing Zhang, Yizhou Hong, Jun Wang and Fangrong Yan
    Citation: Respiratory Research 2020 21:194
    Content type: Letter to the Editor Published on:

  14. From the begging months of 2020 a severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called 2019-nCoV) caused a devastating global outbreak. At present, the diagnosis of coronavirus disease 2019 (...

    Authors: Omid Fakheran, Mandana Dehghannejad and Abbasali Khademi
    Citation: Infectious Diseases of Poverty 2020 9:100
    Content type: Scoping Review Published on:

  15. In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

    Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi
    Citation: Cardiovascular Diabetology 2020 19:114
    Content type: Review Published on:

  16. The outbreak of coronavirus disease 2019 (COVID-19) has caused a public catastrophe and global concern. The main symptoms of COVID-19 are fever, cough, myalgia, fatigue and lower respiratory tract infection si...

    Authors: Xue-Yan Zhang, Hao-Jie Huang, Dong-Lin Zhuang, Moussa Ide Nasser, Ming-Hua Yang, Ping Zhu and Ming-Yi Zhao
    Citation: Infectious Diseases of Poverty 2020 9:99
    Content type: Scoping Review Published on:

  18. Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general popula...

    Authors: Binny Thomas, Abdulrouf Pallivalapila, Wessam El Kassem, Asma Tarannum, Fatema Al Hail, Mohammed Rijims, Hussain Parappil, Arabo Ibrahim Bayo, Shamsa Ahmad, Zachariah Nazar, Derek Stewart and Moza Al Hail
    Citation: Systematic Reviews 2020 9:161
    Content type: Protocol Published on:

  20. Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardio...

    Authors: Changqian Bao, Xiandong Tao, Wei Cui, Bin Yi, Tiewen Pan, Ken H. Young and Wenbin Qian
    Citation: Experimental Hematology & Oncology 2020 9:16
    Content type: Research Published on:

  21. Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and...

    Authors: Hongbing Peng, Tiefeng Gong, Xiaoying Huang, Xun Sun, Hong Luo, Weizhong Wang, Junbiao Luo, Baowei Luo, Yanhui Chen, Xingxing Wang, Haifeng Long, Hua Mei, Chuang Li, Yanni Dai and Honghui Li
    Citation: Stem Cell Research & Therapy 2020 11:291
    Content type: Short report Published on:

  22. Since the first case of coronavirus disease 2019 (COVID-19) in Africa was detected on February 14, 2020, the cumulative confirmations reached 15 207 including 831 deaths by April 13, 2020. Africa has been desc...

    Authors: Salihu S. Musa, Shi Zhao, Maggie H. Wang, Abdurrazaq G. Habib, Umar T. Mustapha and Daihai He
    Citation: Infectious Diseases of Poverty 2020 9:96
    Content type: Research Article Published on:

  23. Coronavirus disease 2019 (COVID-19) has caused a serious epidemic around the world, but it has been effectively controlled in the mainland of China. The Chinese government limited the migration of people almos...

    Authors: Yong Li, Lian-Wen Wang, Zhi-Hang Peng and Hong-Bing Shen
    Citation: Infectious Diseases of Poverty 2020 9:94
    Content type: Research Article Published on:

  24. The world is facing a massive burden from the coronavirus disease 2019 (COVID-19) pandemic. Governments took the extraordinary step of locking down their own countries to curb the spread of the coronavirus. Af...

    Authors: Pier Luigi Ingrassia, Giorgio Capogna, Cristina Diaz-Navarro, Demian Szyld, Stefania Tomola and Esther Leon-Castelao
    Citation: Advances in Simulation 2020 5:13
    Content type: Debate article Published on:

  25. Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide, with numbers increasing dramatically daily. However...

    Authors: Jincheng Xu, Xiaoyue Xu, Lina Jiang, Kamal Dua, Philip M. Hansbro and Gang Liu
    Citation: Respiratory Research 2020 21:182
    Content type: Research Published on:

  26. In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on t...

    Authors: Jie Zhang, Guangping Meng, Wei Li, Bingqing Shi, Hongna Dong, Zhenzhong Su, Qian Huang and Peng Gao
    Citation: Respiratory Research 2020 21:180
    Content type: Research Published on:

  27. The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients during the pandemic in New York City. The pandemic dir...

    Authors: Bo Wang, Oliver Van Oekelen, Tarek H. Mouhieddine, Diane Marie Del Valle, Joshua Richter, Hearn Jay Cho, Shambavi Richard, Ajai Chari, Sacha Gnjatic, Miriam Merad, Sundar Jagannath, Samir Parekh and Deepu Madduri
    Citation: Journal of Hematology & Oncology 2020 13:94
    Content type: Research Published on:

  28. The COVID-19 pandemic is a complex global public health crisis presenting clinical, organisational and system-wide challenges. Different research perspectives on health are needed in order to manage and monito...

    Authors: D. Kringos, F. Carinci, E. Barbazza, V. Bos, K. Gilmore, O. Groene, L. Gulácsi, D. Ivankovic, T. Jansen, S. P. Johnsen, S. de Lusignan, J. Mainz, S. Nuti and N. Klazinga
    Citation: Health Research Policy and Systems 2020 18:80
    Content type: Commentary Published on:

  31. Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and m...

    Authors: Marcos Pereira, Enny Paixão, Anete Trajman, Ramon Andrade de Souza, Marcio Santos da Natividade, Julia M. Pescarini, Susan Martins Pereira, Florisneide Rodrigues Barreto, Ricardo Ximenes, Margareth Dalcomo, Maria Yury Ichihara, Ceuci Nunes, Manoel Barral-Netto and Maurício L. Barreto
    Citation: Respiratory Research 2020 21:178
    Content type: Letter to the Editor Published on:

  32. The recent outbreak by SARS-CoV-2 has generated a chaos in global health and economy and claimed/infected a large number of lives. Closely resembling with SARS CoV, the present strain has manifested exceptiona...

    Authors: Amrita Banerjee, Dipannita Santra and Smarajit Maiti
    Citation: Journal of Translational Medicine 2020 18:281
    Content type: Research Published on:

  33. Shenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia. The city has extensive ties to Hubei Province, the first reported epicenter of the coronavirus ...

    Authors: Huachun Zou, Yuelong Shu and Tiejian Feng
    Citation: Infectious Diseases of Poverty 2020 9:89
    Content type: Commentary Published on:

  34. The new coronavirus disease COVID-19 began in December 2019 and has spread rapidly by human-to-human transmission. This study evaluated the transmissibility of the infectious disease and analyzed its associati...

    Authors: Xiao-Jing Guo, Hui Zhang and Yi-Ping Zeng
    Citation: Infectious Diseases of Poverty 2020 9:87
    Content type: Research Article Published on:

  35. The positive predictive effect of altruism on physical and psychological well-being has been extensively demonstrated in previous studies, but few studies have examined the effect of altruism on negative menta...

    Authors: Yi Feng, Min Zong, Zhizun Yang, Wen Gu, Dan Dong and Zhihong Qiao
    Citation: Globalization and Health 2020 16:61
    Content type: Research Published on:

  36. Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almos...

    Authors: Nitin Chitranshi, Vivek K. Gupta, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Ting Shen, Mehdi Mirzaei, Yuyi You, Devaraj Basavarajappa, Veer Gupta and Stuart L. Graham
    Citation: Journal of Translational Medicine 2020 18:278
    Content type: Research Published on:

  37. Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world health organization (WHO) Due to sudden outbreaks, currently, no ...

    Authors: Shahid Hussain, Ya-Jia Xie, Dan Li, Shaukat Iqbal Malik, Jin-cai Hou, Elaine Lai-Han Leung and Xing-Xing Fan
    Citation: Chinese Medicine 2020 15:70
    Content type: Review Published on:

  39. Coronavirus Disease is impacting the entire world. As the first country that has needed to confront this disease, China has responded with unprecedented and hugely successful public health initiatives. Almost ...

    Authors: Shitao Chen, Feihan Li, Chaihua Lin, Yuge Han, Xilun Nie, Robert N. Portnoy and Zhihong Qiao
    Citation: Globalization and Health 2020 16:59
    Content type: Commentary Published on:

  40. Novel coronavirus SARS-CoV-2 is known to be susceptible in vitro to exposure to hydroxychloroquine and its effect has been found to be potentiated by azithromycin. We hypothesise that early administration of h...

    Authors: František Duška, Petr Waldauf, Milada Halačová, Václav Zvoníček, Jakub Bala, Martin Balík, Jan Beneš, Olga Klementová, Irena Kozáková, Viktor Kubricht, Anne Le Roy, Tomáš Vymazal, Veronika Řehořová and Vladimír Černý
    Citation: Trials 2020 21:631
    Content type: Study protocol Published on:

  41. The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. The adage “old drug, new trick” in this context may suggest the important therapeut...

    Authors: Xi Liu, Huili Chen, Yuqi Shang, Hongqiong Zhu, Gongqi Chen, Yuanli Chen, Shaoxuan Liu, Yaoyong Zhou, Mingxing Huang, Zhongsi Hong and Jinyu Xia
    Citation: Trials 2020 21:622
    Content type: Study protocol Published on:

  42. The Coronavirus disease (COVID-19) is highly infectious, with the recent World Health Organization decree confirming a global public health emergency. The outcomes related to maternal and fetal health among pr...

    Authors: Juliana Vasconcellos Freitas-Jesus, Larissa Rodrigues and Fernanda Garanhani Surita
    Citation: Reproductive Health 2020 17:108
    Content type: Study protocol Published on:

  43. The outbreak of coronavirus disease 2019 (COVID-19) is now becoming an enormous threat to public health. The clinical spectrum of COVID-19 is extensive, of which critical cases are with rapid disease progressi...

    Authors: Shan-Yan Zhang, Jiang-Shan Lian, Jian-Hua Hu, Xiao-Li Zhang, Ying-Feng Lu, Huan Cai, Jue-Qing Gu, Chan-Yuan Ye, Ci-Liang Jin, Guo-Dong Yu, Hong-Yu Jia, Yi-Min Zhang, Ji-Fang Sheng, Lan-Juan Li and Yi-Da Yang
    Citation: Infectious Diseases of Poverty 2020 9:85
    Content type: Research Article Published on:

  44. Since January 2020, after Chinese health authorities identified a new type of coronavirus (SARS-CoV-2), the virus has spread throughout China and consecutively throughout the whole world. The most common sympt...

    Authors: Anne Lampe, Alexander Winschel, Cornelie Lang and Thorsten Steiner
    Citation: Neurological Research and Practice 2020 2:19
    Content type: Letter to the editor Published on:

  45. Previous studies have shown that Coronavirus Disease 2019 (COVID-19) patients with underlying comorbidities can have worse outcomes. However, the effect of hypertension on outcomes of COVID-19 patients remains...

    Authors: Qing Yang, Ying Zhou, Xinrong Wang, Shan Gao, Yang Xiao, Weiming Zhang, Yi Hu and Yafei Wang
    Citation: Respiratory Research 2020 21:172
    Content type: Research Published on:

  46. There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in ...

    Authors: Mei-ying Wu, Lin Yao, Yi Wang, Xin-yun Zhu, Xia-fang Wang, Pei-jun Tang and Cheng Chen
    Citation: Respiratory Research 2020 21:171
    Content type: Research Published on:

  47. Preliminary reports suggest that the Coronavirus Disease 2019 (COVID− 19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. We investigate the racial an...

    Authors: Aniruddh P. Patel, Manish D. Paranjpe, Nina P. Kathiresan, Manuel A. Rivas and Amit V. Khera
    Citation: International Journal for Equity in Health 2020 19:114
    Content type: Letter to the Editor Published on:

  48. The coronavirus disease 2019 (COVID-19) outbreak has seriously endangered the health and lives of Chinese people. In this study, we predicted the COVID-19 epidemic trend and estimated the efficacy of several i...

    Authors: Jian Zu, Miao-Lei Li, Zong-Fang Li, Ming-Wang Shen, Yan-Ni Xiao and Fan-Pu Ji
    Citation: Infectious Diseases of Poverty 2020 9:83
    Content type: Research Article Published on:

  49. The COVID-19 pandemic has had a significant impact on public mental health. Therefore, monitoring and oversight of the population mental health during crises such as a panedmic is an immediate priority. The ai...

    Authors: Nader Salari, Amin Hosseinian-Far, Rostam Jalali, Aliakbar Vaisi-Raygani, Shna Rasoulpoor, Masoud Mohammadi, Shabnam Rasoulpoor and Behnam Khaledi-Paveh
    Citation: Globalization and Health 2020 16:57
    Content type: Research Published on:

  50. The rapid spread of the SARS-CoV-2 epidemic has simultaneous time and space dynamics. This behaviour results from a complex combination of factors, including social ones, which lead to significant differences ...

    Authors: Leonardo Azevedo, Maria João Pereira, Manuel C. Ribeiro and Amílcar Soares
    Citation: International Journal of Health Geographics 2020 19:25
    Content type: Methodology Published on: