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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze

    Citation: Journal of Translational Medicine 2020 18:261

    Content type: Review

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  2. In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated.

    Authors: Abolghasem Allahyari, Hossein Rahimi, Majid Khadem-Rezaiyan, Zahra Mozaheb, Mohsen Seddigh-Shamsi, Alireza Bary, Mostafa Kamandi, Sajad Ataei Azimi, Saeed Eslami HasanAbadi, Alireza Noferesti, Somayeh Sadat Shariatmaghani, Houshang Rafatpanah, Shohreh Khatami, Afshin Jabbar Imani, Hassan Mortazi and Mohammad Moeini Nodeh

    Citation: Trials 2020 21:575

    Content type: Letter

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  3. The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to h...

    Authors: Efrat Shadmi, Yingyao Chen, Inês Dourado, Inbal Faran-Perach, John Furler, Peter Hangoma, Piya Hanvoravongchai, Claudia Obando, Varduhi Petrosyan, Krishna D. Rao, Ana Lorena Ruano, Leiyu Shi, Luis Eugenio de Souza, Sivan Spitzer-Shohat, Elizabeth Sturgiss, Rapeepong Suphanchaimat…

    Citation: International Journal for Equity in Health 2020 19:104

    Content type: Commentary

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  4. The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease...

    Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman

    Citation: Journal of Translational Medicine 2020 18:257

    Content type: Research

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  5. Currently, coronavirus disease 2019 (COVID-19) is continuously and rapidly circulating, causing heavy damage on public health. No effective antiviral treatment has been proved thus far. Traditional Chinese med...

    Authors: Bangjiang Fang, Wen Zhang, Xinxin Wu, Tingrong Huang, Huacheng Li, You Zheng, Jinhua Che, Shuting Sun, Chao Jiang, Shuang Zhou and Jun Feng

    Citation: Trials 2020 21:568

    Content type: Study protocol

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  6. During the COVID-19 pandemic, as a large city located in Southwest China, Chengdu was mainly affected by imported cases. For a psychiatric hospital, the enclosed management model, the crowded wards and the unc...

    Authors: Jiajia Chen, Maoxiang Xiong, Zongling He, Wen Shi, Yuchuan Yue and Manxi He

    Citation: Globalization and Health 2020 16:53

    Content type: Letter to the Editor

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  7. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:251

    Content type: Research

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  8. Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

    Authors: Changzhi Zhou, Zhe Huang, Weijun Tan, Xueying Li, Wen Yin, Yang Xiao, Zhaowu Tao, Shuang Geng and Yi Hu

    Citation: Respiratory Research 2020 21:157

    Content type: Research

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  9. Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

    Authors: Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough and Irfan Rahman

    Citation: Respiratory Research 2020 21:154

    Content type: Research

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  10. Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

    Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

    Citation: Clinical and Translational Allergy 2020 10:23

    Content type: Review

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  11. A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Cov...

    Authors: Celestino Sardu, Giuseppe Gargiulo, Giovanni Esposito, Giuseppe Paolisso and Raffaele Marfella

    Citation: Cardiovascular Diabetology 2020 19:76

    Content type: Commentary

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  12. The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and...

    Authors: Pradeesh Sivapalan, Charlotte Suppli Ulrik, Rasmus Dahlin Bojesen, Therese Sophie Lapperre, Josefin Viktoria Eklöf, Kjell Erik Julius Håkansson, Andrea Browatzki, Casper Tidemansen, Jon Torgny Wilcke, Julie Janner, Vibeke Gottlieb, Howraman Meteran, Celeste Porsbjerg, Birgitte Lindegaard Madsen, Mia Moberg, Lars Pedersen…

    Citation: Trials 2020 21:513

    Content type: Letter

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  13. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito

    Citation: Journal of Translational Medicine 2020 18:233

    Content type: Research

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  14. The purpose of this study is to report the clinical features and outcomes of Black/African American (AA) and Latino Hispanic patients with Coronavirus disease 2019 (COVID-19) hospitalized in an inter-city hosp...

    Authors: Alexis K. Okoh, Christoph Sossou, Neha S. Dangayach, Sherin Meledathu, Oluwakemi Phillips, Corinne Raczek, Michael Patti, Nathan Kang, Sameer A. Hirji, Charles Cathcart, Christian Engell, Marc Cohen, Sandhya Nagarakanti, Eliahu Bishburg and Harpreet S. Grewal

    Citation: International Journal for Equity in Health 2020 19:93

    Content type: Research

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  15. Although research on the effects of comorbidities on coronavirus disease 2019 (COVID-19) patients is increasing, the risk of cancer history has not been evaluated for the mortality of patients with COVID-19.

    Authors: Yifan Meng, Wanrong Lu, Ensong Guo, Jia Liu, Bin Yang, Ping Wu, Shitong Lin, Ting Peng, Yu Fu, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Funian Lu…

    Citation: Journal of Hematology & Oncology 2020 13:75

    Content type: Research

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  16. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2020 18:229

    Content type: Research

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  17. SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that has impacted many aspects of human society. Several issues concerning the origin, time of introduction to humans, evolutionary p...

    Authors: Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen and Hurng-Yi Wang

    Citation: Journal of Biomedical Science 2020 27:73

    Content type: Research

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  18. On December 31, 2019, the World Health Organization was alerted to the occurrence of cases of pneumonia in Wuhan, Hubei Province, China, that were caused by an unknown virus, which was later identified as a co...

    Authors: Soyoung Kim, Sunhwa Choi, Youngsuk Ko, Moran Ki and Eunok Jung

    Citation: Theoretical Biology and Medical Modelling 2020 17:9

    Content type: Research

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  19. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2020 27:72

    Content type: Review

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  20. Citation: Trials 2020 21:475

    Content type: Letter

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  21. COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effe...

    Authors: Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo and Emanuele Marra

    Citation: Journal of Translational Medicine 2020 18:222

    Content type: Commentary

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  22. The COVID-19 pandemic has spread rapidly since the first case notification of the WHO in December 2019. Lacking an effective treatment, countries have implemented non-pharmaceutical interventions including soc...

    Authors: Safia S. Jiwani and Daniel A. Antiporta

    Citation: International Journal for Equity in Health 2020 19:82

    Content type: Short report

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  23. Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be f...

    Authors: Victoria Brazil, Belinda Lowe, Leanne Ryan, Rachel Bourke, Clare Scott, Simone Myers, Hellen Kaneko, Jane Schweitzer and Brenton Shanahan

    Citation: Advances in Simulation 2020 5:9

    Content type: Innovation

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  24. Use of simulation to ensure an organization is ready for significant events, like COVID-19 pandemic, has shifted from a “backburner” training tool to a “first choice” strategy for ensuring individual, team, an...

    Authors: Ryan Brydges, Douglas M. Campbell, Lindsay Beavers, Nazanin Khodadoust, Paula Iantomasi, Kristen Sampson, Alberto Goffi, Filipe N. Caparica Santos and Andrew Petrosoniak

    Citation: Advances in Simulation 2020 5:8

    Content type: Innovation

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  25. The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide. Ironically, this coincides with an immed...

    Authors: Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza and Andre Moreira

    Citation: Journal of Translational Medicine 2020 18:219

    Content type: Commentary

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  26. Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment i...

    Authors: Henrik Carlsson, Karin Hjorton, Sandy Abujrais, Lars Rönnblom, Torbjörn Åkerfeldt and Kim Kultima

    Citation: Arthritis Research & Therapy 2020 22:125

    Content type: Research article

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  27. A cluster of pneumonia cases were reported by Wuhan Municipal Health Commission, China in December 2019. A novel coronavirus was eventually identified, and became the COVID-19 epidemic that affected public hea...

    Authors: Xi Liu, Wen-Tao Luo, Ying Li, Chun-Na Li, Zhong-Si Hong, Hui-Li Chen, Fei Xiao and Jin-Yu Xia

    Citation: Infectious Diseases of Poverty 2020 9:58

    Content type: Research Article

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  28. The novel SARS-CoV-2 coronavirus pandemic has emerged as a truly formidable threat to humankind’s existence. In the wake of the massively volatile global situation created by COVID-19, it is vital to recognize...

    Authors: Akaninyene Otu, Carlo Handy Charles and Sanni Yaya

    Citation: International Journal of Mental Health Systems 2020 14:38

    Content type: Commentary

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  29. The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or vaccines are available to cure ...

    Authors: Yingxin Zhang, Jie Ding, Shaoda Ren, Weihua Wang, Yapei Yang, Shuangjing Li, Min Meng, Tiejun Wu, Daliang Liu, Suochen Tian, Hui Tian, Shuangfeng Chen and Changhui Zhou

    Citation: Stem Cell Research & Therapy 2020 11:207

    Content type: Short report

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  30. Northeastern Nigeria has over the decade suffered from the Boko Haram insurgency and is still in the process of recovery from the complex humanitarian crisis that has displaced and subjected millions of vulner...

    Authors: Salman Jidda Tijjani and Le Ma

    Citation: International Journal for Equity in Health 2020 19:77

    Content type: Commentary

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  31. Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...

    Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

    Citation: Clinical and Translational Allergy 2020 10:16

    Content type: Review

    Published on:

  32. Coronavirus disease 2019 (COVID-19), caused by a novel corinavirus (later named SARS-CoV-2 virus), was fistly reported in Wuhan, Hubei Province, China towards the end of 2019. Large-scale spread within China a...

    Authors: Yeming Wang, Fei Zhou, Dingyu Zhang, Jianping Zhao, Ronghui Du, Yi Hu, Zhenshun Cheng, Ling Gao, Yang Jin, Guangwei Luo, Shouzhi Fu, Qiaofa Lu, Guanhua Du, Ke Wang, Yang Lu, Guohui Fan…

    Citation: Trials 2020 21:422

    Content type: Study protocol

    Published on:

  33. Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity...

    Authors: Jiang Du, Han Li, Jie Lian, Xinxing Zhu, Liang Qiao and Juntang Lin

    Citation: Stem Cell Research & Therapy 2020 11:192

    Content type: Review

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  34. A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at e...

    Authors: Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang and Bo Liang

    Citation: Respiratory Research 2020 21:125

    Content type: Research

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  35. Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive fa...

    Authors: Jingyuan Liu, Yao Liu, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang…

    Citation: Journal of Translational Medicine 2020 18:206

    Content type: Research

    Published on:

  36. Since its introduction in modern medicine, naturalistic observations emerged about possible uses of lithium treatment for conditions different from recurring affective disorders, for which it is still a first-...

    Authors: Andrea Murru, Mirko Manchia, Tomas Hajek, René E. Nielsen, Janusz K. Rybakowski, Gabriele Sani, Thomas G. Schulze, Leonardo Tondo and Michael Bauer

    Citation: International Journal of Bipolar Disorders 2020 8:21

    Content type: Review

    Published on:

  37. The need for life-saving interventions such as mechanical ventilation may threaten to outstrip resources during the Covid-19 pandemic. Allocation of these resources to those most likely to benefit can be suppo...

    Authors: David M. Kent, Jessica K. Paulus, Richard R. Sharp and Negin Hajizadeh

    Citation: Diagnostic and Prognostic Research 2020 4:11

    Content type: Commentary

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  38. The COVID-19 pandemic has become the leading societal concern. The pandemic has shown that the public health concern is not only a medical problem, but also affects society as a whole; so, it has also become t...

    Authors: Negar Moradian, Hans D. Ochs, Constantine Sedikies, Michael R. Hamblin, Carlos A. Camargo Jr., J. Alfredo Martinez, Jacob D. Biamonte, Mohammad Abdollahi, Pedro J. Torres, Juan J. Nieto, Shuji Ogino, John F. Seymour, Ajith Abraham, Valentina Cauda, Sudhir Gupta, Seeram Ramakrishna…

    Citation: Journal of Translational Medicine 2020 18:205

    Content type: Review

    Published on:

  39. In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the W...

    Authors: Christopher J. Rogers, Robert J. Harman, Bruce A. Bunnell, Martin A. Schreiber, Charlie Xiang, Fu-Sheng Wang, Antonio F. Santidrian and Boris R. Minev

    Citation: Journal of Translational Medicine 2020 18:203

    Content type: Review

    Published on:

  40. In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unk...

    Authors: Jehun Song, Seongmin Kang, Seung Won Choi, Kwang Won Seo, Sunggun Lee, Min Wook So and Doo-Ho Lim

    Citation: Rheumatology International 2020 40:4584

    Content type: Cases with a Message

    Published on: