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Overcoming Publication Bias in Clinical Trials

An article collection published in Journal of Negative Results in BioMedicine.

Clinical trials are one of our most valuable types of research for identifying cause-and-effect in regards to healthcare interventions. Publication of all clinical trial results, regardless of outcome or significance of findings, is not only an ethical responsibility but also enables the efficacy of interventions to be validated, while preventing undue risk to patients and waste of resources.

This special article collection brings together null and non-confirmatory results from randomized controlled trials that have been published in Journal of Negative Results in BioMedicine. With this article collection we celebrate those authors who support completing the published record and call for others to submit their null and non-confirmatory results to the journal.

  1. Brief report

    Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study

    Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d...

    Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long

    Journal of Negative Results in BioMedicine 2015 14:21

    Published on: 2 December 2015

  2. Research

    A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease

    Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (...

    Eskandarain Shafuddin, Graham D. Mills, Mark D. Holmes, Phillippa J. Poole, Peter R. Mullins and Peter N. Black

    Journal of Negative Results in BioMedicine 2015 14:15

    Published on: 7 September 2015

  3. Research

    No effects of a 12-week supervised exercise therapy program on gait in patients with mild to moderate osteoarthritis: a secondary analysis of a randomized trial

    It is unknown whether gait biomechanics in hip osteoarthritis patients with mild to moderate symptoms change following exercise therapy interventions. The aim of the present study was to compare stance phase g...

    Ingrid Eitzen, Linda Fernandes, Lars Nordsletten and May Arna Risberg

    Journal of Negative Results in BioMedicine 2015 14:5

    Published on: 5 March 2015

  4. Research

    A double-blind, randomized controlled, prospective trial assessing the effectiveness of oral corticoids in the treatment of symptomatic lumbar canal stenosis

    Corticoids have potent anti-inflammatory effects, which may help in relieving pain and dysfunction associated with lumbar canal stenosis. We assessed the effectiveness of a decreasing-dose regimen of oral cort...

    Luiz Claudio L Rodrigues and Jamil Natour

    Journal of Negative Results in BioMedicine 2014 13:13

    Published on: 7 August 2014

  5. Research

    Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids

    Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (...

    Jan Lötvall, Eric D Bateman, William W Busse, Paul M O’Byrne, Ashley Woodcock, William T Toler, Loretta Jacques, Caroline Goldfrad and Eugene R Bleecker

    Journal of Negative Results in BioMedicine 2014 13:9

    Published on: 13 June 2014

  6. Research

    A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma

    Design and execution of immunotherapy trials for seasonal allergies may be complicated by numerous factors including variable allergy testing methods, pollen levels, and timing and intensity of other seasonal ...

    Kevin Murphy, Sandra Gawchik, David Bernstein, Jens Andersen and Martin Rud Pedersen

    Journal of Negative Results in BioMedicine 2013 12:10

    Published on: 1 June 2013

  7. Research

    No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial

    The underlying pathology and natural course of Modic changes (MC) in the vertebral body marrow and high intensity zones (HIZs) in the annulus fibrosus is not completely clarified. These findings on magnetic re...

    Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg and Ansgar Espeland

    Journal of Negative Results in BioMedicine 2012 11:13

    Published on: 17 August 2012

  8. Research

    Methylphenidate for treating tobacco dependence in non-attention deficit hyperactivity disorder smokers: A pilot randomized placebo-controlled trial

    Methylphenidate blocks the re-uptake of dopamine by binding to the dopamine transporter in the presynaptic cell membrane and increases extracellular dopamine levels. Similarities in neuropsychologic effects be...

    Richard D Hurt, Jon O Ebbert, Ivana T Croghan, Darrell R Schroeder, Amit Sood and J Taylor Hays

    Journal of Negative Results in BioMedicine 2011 10:1

    Published on: 28 January 2011

  9. Research

    Prospective randomized trial of iliohypogastric-ilioinguinal nerve block on post-operative morphine use after inpatient surgery of the female reproductive tract

    To determine the impact of pre-operative and intra-operative ilioinguinal and iliohypogastric nerve block on post-operative analgesic utilization and length of stay (LOS).

    Salim A Wehbe, Labib M Ghulmiyyah, El-Khawand H Dominique, Sarah L Hosford, Carole M Ehleben, Steven L Saltzman and Eric Scott Sills

    Journal of Negative Results in BioMedicine 2008 7:11

    Published on: 28 November 2008

  10. Research

    Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

    Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) ...

    Martin O Weickert, Manja Reimann, Bärbel Otto, Wendy L Hall, Katherina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M Williams, Hans-Joachim Zunft and Corinna Koebnick

    Journal of Negative Results in BioMedicine 2006 5:11

    Published on: 14 August 2006