Gerontology has traditionally been dominated by biological research groups. In recent years, the potential impact of chemical analysis and small molecule interventions has become widely recognised, and there are now a growing number of chemists undertaking ageing research. Research into ageing spans the full range chemistry. Advanced analytical and physical techniques are being used to observe age-related changes in living organisms. Equally, novel synthetic and medicinal chemistry is generating small molecule tools for the dissection of complex biological pathways, as well as potential life- and health-span extending therapeutics.
This thematic issue on the chemistry of ageing covers topics such as: glycation, oxidative stress and other degenerative processes; cellular senescence, mechanistic dissection and interventions; telomerase inhibitors and activators; small molecules with life-extending activity such as resveratrol and rapamycin; and novel methods for mining complex cohort and life-course data.
Editor: Dr Elizabeth Ostler