Edited by: Zhe Li
Severe burns damage skin structures and skin cellular components, the essential building blocks and machinery for wound repair and skin regeneration.
Cell-based therapies as alternative or adjunct devices to standard skin grafting have demonstrated therapeutic potentials at cellular, molecular and tissue regenerative levels in severe burn wound healing. Cell therapy may be utilized to deliver various types of living cells that are critically needed for wound repair. The delivered cells could produce the essential molecules or biological factors that regulate the process of wound healing. Furthermore, cell therapy in combination with dermal regenerative templates would enable the development of scaffold-guided skin tissue engineering that potentially hold the ultimate resolution for burn wound healing and complete skin regeneration.
This thematic collection includes expert reviews on current knowledge and challenging issues in cell therapy for burns. Although significant advances have been made in past decades, many challenging issues are still to be solved to achieve the full impact of cell therapy in burn wound care.
This series was published in Burns & Trauma.