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Cerebrovascular Disorders

Guest Editors:
Alessandra Granata: University of Cambridge, UK
Eric Harshfield: University of Cambridge, UK
Joseph V Moxon: James Cook University, Australia

BMC Cardiovascular Disorders has published this Collection on Cerebrovascular Disorders. Cerebrovascular disorders comprise a range of distinct pathologies, including ischaemic and haemorrhagic stroke, transient ischaemic attack, and other intracranial vascular disorders (e.g. vascular malformations and unruptured aneurysms), and significantly increase the risk of vascular dementia. Cerebrovascular disorders represent a significant medical and economic challenge which is anticipated to increase in parallel with a global ageing population. The past decade has brought great progress in diagnostic and therapeutic options but more needs to be done to improve the life of patients. Advances in basic science techniques and medical technologies hold great potential to improve the management of cerebrovascular disorders in the coming decades; however, rigorously designed translational research programs are needed to bring novel discoveries to the clinic.

Meet the Guest Editors

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Alessandra Granata: University of Cambridge, UK

Alessandra Granata is a Research Fellow at the University of Cambridge with more than 10 years experience in modeling disease using human induced pluripotent stem cells. She joined the Stroke research group, department of Clinical Neurosciences in 2016 and established a translational research group that uses induced pluripotent stem cells (hiPSC) derived from patients with genetic form of cerebral small vessel diseases and stroke to investigate underlying pathogenic mechanisms.

Eric Harshfield: University of Cambridge, UK

Dr Harshfield is a Research Fellow in the Department of Clinical Neurosciences at the University of Cambridge. He received his PhD in Epidemiology from the University of Cambridge in 2018. His research uses genetics and multi-omics to identify improved ways to predict, prevent, and treat stroke and dementia.

Joseph V Moxon: James Cook University, Australia

Joe Moxon is a Senior Research Fellow and Associate Dean, Research at the James Cook University College of Medicine and Dentistry. Joe’s research focuses on identifying novel treatments, biomarkers and risk factors for vascular disease, using a range of laboratory and clinical approaches. Joe was the lead statistician on several published randomised controlled trials investigating novel treatments for abdominal aortic aneurysm (AAA) and is a chief investigator for ongoing trials focusing on AAA, lower limb atherosclerosis and diabetic foot complications. Most recently Joe has collaborated with clinicians involved in the care of ischaemic stroke patients, to identify novel stroke diagnostics and prognostics.

About the collection

This collection in BMC Cardiovascular Disorders explores the spectrum from translational basic science to clinical research which aim to improve our understanding of cerebrovascular disorders. 

Topics of interest included, but were not limited to:

● Epidemiology of cerebrovascular disease
● Investigations into the biology and management of vascular malformations
● Atherosclerosis and inflammation affecting the cerebrovasculature
● Biology of the blood-brain barrier
● Relationship between infection, inflammation and stroke
● Cerebrovascular imaging
● Transcriptomic mapping of the human cerebro-vasculature
● Application of novel omics technologies to understand cerebrovascular disorders

  1. Clinical risk factors associated obesity and smoking, as well as their combined effect, are not fully understood. This study aims to determine sex differences in risk factors in a population of acute ischemic ...

    Authors: Dami T. Ojo, Philip C. Brewer, Adebobola Imeh-Nathaniel, Samuel Imeh-Nathaniel, Philip X. Broughton and Thomas I. Nathaniel
    Citation: BMC Cardiovascular Disorders 2024 24:288
  2. Several studies have investigated the correlation between phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP) rs918592 and the risk of ischemic stroke (IS) in Chinese populations. But the results we...

    Authors: Xinrui Yu, Guiying Zhang, Xuelei Tang and Rong Lin
    Citation: BMC Cardiovascular Disorders 2024 24:17
  3. Cerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic approaches, have improved our understanding and ma...

    Authors: Alessandra Granata, Eric L Harshfield and Joseph V Moxon
    Citation: BMC Cardiovascular Disorders 2023 23:212

Submission Guidelines

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This Collection welcomes submission of Research Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Cerebrovascular Disorders" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.