Edited by:
Elisabeth Nacheva: UCL School of Life and Medical Sciences, and Health Service Laboratories, London, United Kingdom
Molecular Cytogenetics is calling for submissions to our new Collection on Cytogenomics of Haematological Malignancies.
Image credit: Rodrusoleg / Getty Images / iStock
This Collection will address the latest developments in the diagnosis of haematological malignancies. The application of next generation sequencing (NGS) and molecular karyotyping (chromosome microarray, CMA) into routine laboratory investigations, along with classical approaches, have significantly changed the accuracy and speed of diagnostic processes. The availability of different platforms of both NGS and CMA offers ways of customising the diagnostic routines to adapt to local requirements. As genetic profiles of haematological cancers are diverse, creating algorithms to provide a comprehensive, timely and cost-effective cover for most common disorders is a challenge. Many questions need to be addressed including:
• What would be a recommended panel for target NGS? Should it be a dedicated myeloid/lymphoid or combined panel?
• Do combined DNA/RNA based NGS panels offer a comprehensive cover?
• Should high resolution CMA/LOH replace G banding?
• Do NGS panels provide sufficient information about copy number changes, CNVs and/or SNPs?
• Is it time to replace FISH? If so, what would be an easy, fast, and cost-effective alternative?
• Could optical genome mapping (OGM) be a first line diagnostic tool?
• How to conduct MRD screening?
The aim of this Collection is to discuss alternatives for obtaining comprehensive genetic profiling to assist the diagnosis and treatment options until such times when a single whole genome sequencing test would be available.
There are currently no articles in this collection.
This Collection welcomes submission of original Research Articles and Reviews.
Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Cytogenomics of Haematological Malignancies" from the dropdown menu.
Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.
The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.