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Role of Synthetic Biology and Gene Engineering in CAR Immunotherapy

Guest Editors: Profs Marko Radic, Djordje Atanackovic and Tim Luetkens

BMC Cancer is currently accepting submissions to a thematic series entitled 'The Advances of CAR Immunotherapy within Oncology Clinics'. 

Chimeric antigen receptor (CAR) T cells therapies, as a novel modality in cancer immunotherapy, provide a quantum leap in the treatment of cancer.  In recognition of the new advances that the CAR approach represents in heNew Content Itemmatological malignancies, the Food and Drug Administration (FDA) recently approved two separate cell-based gene therapies, one from Novartis (Kamryah) the other from Gilead (Yescarta), for treatment of B cell leukemias.  These concrete steps that advance the CAR therapy into the clinic provide the backdrop and motivation to assist the integration of the CAR immunotherapy into the standard treatment modalities of cancer.  We envision that accelerated progress with clinical trials of CAR T cells, the proper dosing of engineered T cells along with optimized GMP-compliant production of patient-derived T lymphocytes, combination therapies using CAR T cells and additional chemo- and immune-therapies, and increased safety considerations with diminished side-effects will remain the focus of scientific investigations.  As such, manuscripts dealing with any of these related topics fit within the scope of this new thematic series.

BMC Cancer, in collaboration with BMC Biotechnology, have agreed to jointly host the thematic series.  To present the recent advances in the applications and safety of CAR immunotherapy, we invite you and/or members of your research team to submit manuscript(s) for this thematic series.

We are seeking submissions of original research articles (including systematic reviews and meta-analyses), but also commentary articles. This collection will also include invited reviews.

We would welcome direct submission of any original research you would like to be considered. Please submit directly to BMC Cancer or BMC Biotechnology stating in your cover letter that you are targeting the 'CAR Immunotherapy' collection

  1. Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that c...

    Authors: Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini and Umberto Sabatini

    Citation: BMC Cancer 2019 19:1197

    Content type: Case report

    Published on:

  2. Simultaneous advances in gene editing, T cell engineering and biotechnology currently provide an opportunity for rapid progress in medicine. The approval of chimeric antigen receptor (CAR) T cell therapies by ...

    Authors: Noah H. Richardson, Jordan B. Luttrell, Jonathan S. Bryant, Damian Chamberlain, Saleem Khawaja, Indira Neeli and Marko Radic

    Citation: BMC Biotechnology 2019 19:84

    Content type: Review

    Published on:

  3. Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

    Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang

    Citation: BMC Cancer 2019 19:1116

    Content type: Database

    Published on:

  4. Engineered therapeutic cells have attracted a great deal of interest due to their potential applications in treating a wide range of diseases, including cancer and autoimmunity. Chimeric antigen receptor (CAR)...

    Authors: Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, St├ęphane Depil and Philippe Duchateau

    Citation: BMC Biotechnology 2019 19:44

    Content type: Research article

    Published on:

  5. Adoptive transfer of T cells genetically engineered with a chimeric antigen receptor (CAR) has successfully been used to treat both chronic and acute lymphocytic leukemia as well as other hematological cancers...

    Authors: Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja and Magnus Essand

    Citation: BMC Cancer 2014 14:30

    Content type: Research article

    Published on: