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Diabetes: prevention, management and treatment

Guest Editors: Prof Naveed Sattar and Prof John Petrie

Recent years have seen a sharp increase in the prevalence of Type 2 diabetes globally, affecting younger adults and even children. This is associated with rising levels of obesity, and lifestyle factors including low levels of physical activity and unhealthy diet, as well as lowered mortality rates in high income countries. The prevalence of Type 1 diabetes is also increasing although it remains unclear why.

In response to this rising epidemic, there have been impressive advances in research and treatment, including diet-based approaches, lifestyle modification, bariatric surgery, clinical trials (novel insulin analogues, GLP-1 agonists, SGLT2 inhibitors) stem cell-based approaches, the artificial pancreas and smart technology, to name just a few.

We are seeking submissions of original research articles (including systematic reviews and meta-analyses) that provide important insights into pathogenesis, genetic risk factors, ethnicity, risk factor multipliers, management of the disease in complex patients (including the very elderly, and younger adults and children), pharmacotherapy and new data from ongoing trials. This collection in BMC Medicine will also include invited reviews, debates and commentaries.

  1. Research article

    A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial

    There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-inte...

    Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi and Janaka Karalliedde

    BMC Medicine 2017 15:146

    Published on: 30 August 2017

  2. Research article

    Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

    In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and ty...

    Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, Kenyaita M. Hodge, Vanessa C. Guy, Hakon Hakonarson, Didac Mauricio, Nanette C. Schloot, Knud B. Yderstræde, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie and Struan F. A. Grant

    BMC Medicine 2017 15:88

    Published on: 25 April 2017

  3. Research article

    Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery

    The ileal-derived hormone, fibroblast growth factor 19 (FGF-19), may promote weight loss and facilitate type-2 diabetes mellitus remission in bariatric surgical patients. We investigated the effect of differen...

    Lucia Martinez de la Escalera, Ioannis Kyrou, Jana Vrbikova, Voitech Hainer, Petra Sramkova, Martin Fried, Milan K. Piya, Sudhesh Kumar, Gyanendra Tripathi and Philip G. McTernan

    BMC Medicine 2017 15:34

    Published on: 16 February 2017

  4. Research article

    The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial

    Maternal overweight and obesity during pregnancy is associated with insulin resistance, hyperglycaemia, hyperlipidaemia and a low-grade state of chronic inflammation. The aim of this pre-specified analysis of ...

    Lisa J. Moran, Louise M. Fraser, Tulika Sundernathan, Andrea R. Deussen, Jennie Louise, Lisa N. Yelland, Rosalie M. Grivell, Anne Macpherson, Matthew W. Gillman, Jeffrey S. Robinson, Julie A. Owens and Jodie M. Dodd

    BMC Medicine 2017 15:32

    Published on: 14 February 2017

  5. Research article

    Obesity and type 2 diabetes in sub-Saharan Africans – Is the burden in today’s Africa similar to African migrants in Europe? The RODAM study

    Rising rates of obesity and type 2 diabetes (T2D) are impending major threats to the health of African populations, but the extent to which they differ between rural and urban settings in Africa and upon migra...

    Charles Agyemang, Karlijn Meeks, Erik Beune, Ellis Owusu-Dabo, Frank P. Mockenhaupt, Juliet Addo, Ama de Graft Aikins, Silver Bahendeka, Ina Danquah, Matthias B. Schulze, Joachim Spranger, Tom Burr, Peter Agyei-Baffour, Stephen K. Amoah, Cecilia Galbete, Peter Henneman…

    BMC Medicine 2016 14:166

    Published on: 21 October 2016

  6. Research article

    Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study

    The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes...

    Layal Chaker, Symen Ligthart, Tim I. M. Korevaar, Albert Hofman, Oscar H. Franco, Robin P. Peeters and Abbas Dehghan

    BMC Medicine 2016 14:150

    Published on: 30 September 2016

  7. Research article

    No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

    Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder worldwide, reaching prevalence up to 90 % in obese patients with type 2 diabetes (T2D), and representing an independent risk factor...

    Ilaria Barchetta, Maria Del Ben, Francesco Angelico, Michele Di Martino, Antonio Fraioli, Giuseppe La Torre, Rosella Saulle, Ludovica Perri, Sergio Morini, Claudio Tiberti, Laura Bertoccini, Flavia Agata Cimini, Francesca Panimolle, Carlo Catalano, Marco Giorgio Baroni and Maria Gisella Cavallo

    BMC Medicine 2016 14:92

    Published on: 29 June 2016