Skip to main content

Alternative interventions to facilitate malaria elimination

It is now well-established that well-coordinated interventions are essential for malaria elimination, including integrated vector control management (with insecticide-treated bed nets and indoor residual spraying), reliable detection of cases, effective drugs for prevention and treatment, together with community involvement and enthusiasm to adhere to the interventions. After initial success, most programmes have reached stagnation, with progressive loss of earlier gains. The pressure needs to be kept full on, not only on policy-makers and sponsors to maintain and amplify the global effort in the long term, but also on the research community to continue developing new tools. Obviously, an effective vaccine (or vaccines) would be a powerful addition to the arsenal, and this is much needed, but vaccines have proven to be a difficult target to achieve. While waiting for the elusive vaccine, many have been looking for feasible alternatives and inventive new approaches adapted to specific situations or capable of solving specific problems. Such alternatives, big and small, have incremental value and in terms of elimination, every little helps. 

This Thematic series in Malaria Journal will collect published papers on innovative approaches and invite new contributions to stimulate further research.

  1. The preventive and curative strategies of malaria are based on promoting the use of long-lasting insecticidal nets (LLINs) and treating confirmed cases with artemisinin-based combination therapy. These strateg...

    Authors: El Hadji Diouf, Mbaye Diouf, Constentin Dieme, Isabel Swamidoss, El Hadji Malick Ngom, Massila Wagué Senghor, Modou Mbaye, Abdoulaye Konaté, Youssouph Coulibaly, Dome Tine, Ibrahima Dia, Ellen Marie Dotson, Ousmane Faye and Lassana Konaté
    Citation: Malaria Journal 2022 21:210
  2. In Burkina Faso, malaria remains the first cause of medical consultation and hospitalization in health centres. First-line case management of malaria in the country’s health facilities is based on the use of a...

    Authors: Denise Hien, Jean Moise Tanga Kaboré, Mohamadou Siribié, Issiaka Soulama, Nouhoun Barry, Adama Baguiya, Alfred Bewendtaoré Tiono, André-Marie Tchouatieu and Sodiomon Bienvenu Sirima
    Citation: Malaria Journal 2022 21:202
  3. Across the Greater Mekong Subregion, malaria remains a dangerous infectious disease, particularly for people who visit forested areas where residual transmission continues. Because vector control measures offe...

    Authors: Monnaphat Jongdeepaisal, Panarasri Khonputsa, Orathai Prasert, Suphitsara Maneenet, Kulchada Pongsoipetch, Anchalee Jatapai, Chawarat Rotejanaprasert, Prayuth Sudathip, Richard J. Maude and Christopher Pell
    Citation: Malaria Journal 2022 21:47
  4. Despite significant decline in malarial incidence and mortality in countries across the Greater Mekong Subregion, the disease remains a public health challenge in the region; transmission continues mainly amon...

    Authors: Monnaphat Jongdeepaisal, Soulixay Inthasone, Panarasri Khonputsa, Vilayvone Malaphone, Kulchada Pongsoipetch, Tiengkham Pongvongsa, Mayfong Mayxay, Keobouphaphone Chindavongsa, Christopher Pell and Richard J. Maude
    Citation: Malaria Journal 2022 21:8
  5. Although considerable success in reducing the incidence of malaria has been achieved in Brazil in recent years, an increase in the proportion of cases caused by the harder-to-eliminate Plasmodium vivax parasite c...

    Authors: Cleber Matos de Morais, Kayo Henrique de Carvalho Monteiro, Jose Diego Brito-Sousa, Wuelton Marcelo Monteiro, Vanderson Souza Sampaio, Patricia Takako Endo and Judith Kelner
    Citation: Malaria Journal 2021 20:431
  6. Supplementary tools are required to address the limitations of insecticide-treated nets (ITNs) and indoor residual spraying (IRS), which are currently the core vector control methods against malaria in Africa....

    Authors: Emmanuel W. Kaindoa, Arnold S. Mmbando, Ruth Shirima, Emmanuel E. Hape and Fredros O. Okumu
    Citation: Malaria Journal 2021 20:415
  7. Insecticides are currently the main tools used to reduce the transmission of malaria; therefore, the development of resistance to insecticides in malaria vectors is of major concern for malaria control. The re...

    Authors: Abdoulaye Niang, Simon P. Sawadogo, Abdoul A. Millogo, Nwamaka O. Akpodiete, Roch K. Dabiré, Frederic Tripet and Abdoulaye Diabaté
    Citation: Malaria Journal 2021 20:346
  8. Malaria is one of the leading causes of morbidity and mortality in African countries. It is one of the leading causes of hospital visits and hospitalization in pediatric wards for children under 5 years old. I...

    Authors: Gaëtan Moukoumbi Lipenguet, Edgard Brice Ngoungou, Euloge Ibinga, Jean Engohang-Ndong and Jérôme Wittwer
    Citation: Malaria Journal 2021 20:334
  9. MOSKI KIT® is a fun tool designed to interest children for prevention and management of malaria. This study was carried out with the objective to assess the short- and long-term impacts of this tool on the kno...

    Authors: Isaac Akhénaton Manga, Aïssatou Gaye, Aliou Dia, Ekoue Kouevidjin, Maria Rosa Dos Reis, Aboubakry Sadikh Niang, Amy Ndao Fall, Christelle Maitre Anquetil and Jean Louis Abdourahim Ndiaye
    Citation: Malaria Journal 2021 20:310
  10. In malaria endemic regions, intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for all pregnant women during prenatal consultation, from the fourth month of pregnancy up ...

    Authors: Oumar Sangho, Moctar Tounkara, Lillian Joyce Whiting-Collins, Madeleine Beebe, Peter J. Winch and Seydou Doumbia
    Citation: Malaria Journal 2021 20:231
  11. Reactive case detection (RACD) and foci investigation are key strategies in malaria elimination and prevention of its re-establishment. They are a key part of surveillance that has been recommended by the Worl...

    Authors: Ruwanthi Perera, Amandhi Caldera and A. Rajitha Wickremasinghe
    Citation: Malaria Journal 2020 19:401
  12. Following malaria elimination, Sri Lanka was free from indigenous transmission for six consecutive years, until the first introduced case was reported in December 2018. The source of transmission (index case) ...

    Authors: Manonath M. Marasinghe, Vissundara M. Karunasena, Arundika S. Seneratne, Hema D. B. Herath, Deepika Fernando, Rajitha Wickremasinghe, Kamini N. Mendis and Dewanee Ranaweera
    Citation: Malaria Journal 2020 19:346
  13. Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explore...

    Authors: Marceline F. Finda, Nicola Christofides, Javier Lezaun, Brian Tarimo, Prosper Chaki, Ann H. Kelly, Ntuli Kapologwe, Paul Kazyoba, Basiliana Emidi and Fredros O. Okumu
    Citation: Malaria Journal 2020 19:164
  14. Cambodia targets malaria elimination by 2025. Rapid elimination will depend on successfully identifying and clearing malaria foci linked to forests. Expanding and maintaining universal access to early diagnosi...

    Authors: Dysoley Lek, James J. Callery, Chea Nguon, Mark Debackere, Siv Sovannaroth, Rupam Tripura, Marius Wojnarski, Patrice Piola, Soy Ty Khean, Kylie Manion, Sokomar Nguon, Amber Kunkel, Lieven Vernaeve, Thomas J. Peto, Emily Dantzer, Chan Davoeung…
    Citation: Malaria Journal 2020 19:151
  15. Outdoor and early evening mosquito biting needs to be addressed if malaria elimination is to be achieved. While indoor-targeted interventions, such as insecticide-treated nets and indoor residual spraying, rem...

    Authors: Onyango P. Sangoro, Tegemeo Gavana, Marceline Finda, Winfrida Mponzi, Emmanuel Hape, Alex Limwagu, Nicodem J. Govella, Prosper Chaki and Fredros O. Okumu
    Citation: Malaria Journal 2020 19:148
  16. Despite huge investments and implementation of effective interventions for malaria, progress has stalled, with transmission being increasingly localized among difficult-to-reach populations and outdoor-biting ...

    Authors: Roly Gosling, John Chimumbwa, Petrina Uusiku, Sara Rossi, Henry Ntuku, Kelly Harvard, Chris White, Allison Tatarsky, Daniel Chandramohan and Ingrid Chen
    Citation: Malaria Journal 2020 19:125
  17. Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. T...

    Authors: John P. Masalu, Marceline Finda, Gerry F. Killeen, Halfan S. Ngowo, Polius G. Pinda and Fredros O. Okumu
    Citation: Malaria Journal 2020 19:109
  18. Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of r...

    Authors: Benjamin Grossenbacher, Aurel Holzschuh, Natalie E. Hofmann, Kali Abdullah Omar, Logan Stuck, Bakar Shariff Fakih, Abdullah Ali, Joshua Yukich, Manuel W. Hetzel and Ingrid Felger
    Citation: Malaria Journal 2020 19:50