Skip to main content


Application of zebrafish in biomedical research

Edited by Prof Chiaho Shih

The tropical zebrafish is a popular aquarium fish, yet it is also an important vertebrate model organism in scientific research for studying developmental processes and human diseases.

This special series, published in Journal of Biomedical Science, focuses on the use of zebrafish for discovering novel development and pathogenesis pathways, and developing new therapies against diseases.

Read our blog on this series.

  1. Content type: Research

    Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previousl...

    Authors: Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao and Yung-Jen Chuang

    Citation: Journal of Biomedical Science 2016 23:59

    Published on:

  2. Content type: Research

    Yin Yang 1 (YY1) is a ubiquitously expressed GLI-Kruppel zinc finger-containing transcriptional regulator. YY1 plays a fundamental role in normal biologic processes such as embryogenesis, differentiation, and ...

    Authors: Wei-Lun Shiu, Kuan-Rong Huang, Jo-Chi Hung, Jen-Leih Wu and Jiann-Ruey Hong

    Citation: Journal of Biomedical Science 2016 23:31

    Published on:

  3. Content type: Research

    The axonal tau protein is a tubulin-binding protein, which plays important roles in the formation and stability of the microtubule. Mutations in the tau gene are associated with familial forms of frontotempora...

    Authors: Bo-Kai Wu, Rey-Yue Yuan, Huang-Wei Lien, Chin-Chun Hung, Pung-Pung Hwang, Rita Pei-Yeh Chen, Chun-Che Chang, Yung-Feng Liao and Chang-Jen Huang

    Citation: Journal of Biomedical Science 2016 23:25

    Published on:

  4. Content type: Research

    Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Authors: Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou

    Citation: Journal of Biomedical Science 2015 22:105

    Published on:

  5. Content type: Research

    The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is not fully characterized. The orphan nuclear receptor Chicken ovalbumin upstream promoter trans...

    Authors: Ru-Fang Li, Ting-Yun Wu, Yu-Zheng Mou, Yi-Shan Wang, Chun-Lin Chen and Chang-Yi Wu

    Citation: Journal of Biomedical Science 2015 22:104

    Published on:

  6. Content type: Research

    Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects ...

    Authors: Chih-Lun Cheng, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Chuian-Fu Ken, Shao-Yang Hu and Jen-Leih Wu

    Citation: Journal of Biomedical Science 2015 22:103

    Published on:

  7. Content type: Research

    Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Authors: Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng

    Citation: Journal of Biomedical Science 2015 22:102

    Published on: