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Application of zebrafish in biomedical research

Edited by Prof Chiaho Shih

The tropical zebrafish is a popular aquarium fish, yet it is also an important vertebrate model organism in scientific research for studying developmental processes and human diseases.

This special series, published in Journal of Biomedical Science, focuses on the use of zebrafish for discovering novel development and pathogenesis pathways, and developing new therapies against diseases.

Read our blog on this series.

  1. Research

    Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway

    Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previousl...

    Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao and Yung-Jen Chuang

    Journal of Biomedical Science 2016 23:59

    Published on: 2 August 2016

  2. Research

    Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development

    Yin Yang 1 (YY1) is a ubiquitously expressed GLI-Kruppel zinc finger-containing transcriptional regulator. YY1 plays a fundamental role in normal biologic processes such as embryogenesis, differentiation, and ...

    Wei-Lun Shiu, Kuan-Rong Huang, Jo-Chi Hung, Jen-Leih Wu and Jiann-Ruey Hong

    Journal of Biomedical Science 2016 23:31

    Published on: 29 February 2016

  3. Research

    Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo

    The axonal tau protein is a tubulin-binding protein, which plays important roles in the formation and stability of the microtubule. Mutations in the tau gene are associated with familial forms of frontotempora...

    Bo-Kai Wu, Rey-Yue Yuan, Huang-Wei Lien, Chin-Chun Hung, Pung-Pung Hwang, Rita Pei-Yeh Chen, Chun-Che Chang, Yung-Feng Liao and Chang-Jen Huang

    Journal of Biomedical Science 2016 23:25

    Published on: 6 February 2016

  4. Review

    Zebrafish and Medaka: new model organisms for modern biomedical research

    Although they are primitive vertebrates, zebrafish (Danio rerio) and medaka (Oryzias latipes) have surpassed other animals as the most used model organisms based on their many advantages. Studies on gene expressi...

    Cheng-Yung Lin, Cheng-Yi Chiang and Huai-Jen Tsai

    Journal of Biomedical Science 2016 23:19

    Published on: 28 January 2016

  5. Research

    Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish

    Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng

    Journal of Biomedical Science 2015 22:102

    Published on: 17 November 2015

  6. Research

    Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection

    Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects ...

    Chih-Lun Cheng, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Chuian-Fu Ken, Shao-Yang Hu and Jen-Leih Wu

    Journal of Biomedical Science 2015 22:103

    Published on: 17 November 2015

  7. Research

    Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae

    Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou

    Journal of Biomedical Science 2015 22:105

    Published on: 17 November 2015