Significance of the multiomics approach to elucidate disease mechanisms in humans
Citation:
Inflammation and Regeneration
2022
42:41
Application of human genomics to clinical medicine (Single cell)
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Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition
Even within a single type of cancer, cells of various types exist and play interrelated roles. Each of the individual cells resides in a distinct microenvironment and behaves differently. Such heterogeneity is...
Citation: Inflammation and Regeneration 2021 41:22 -
Inborn errors of immunity—recent advances in research on the pathogenesis
Primary immunodeficiency (PID) is a genetic disorder with a defect of one of the important components of our immune system. Classical PID has been recognized as a disorder with loss of function of the immune s...
Citation: Inflammation and Regeneration 2021 41:9 -
Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by tumor-like hyperplasia and inflammation of the synovium, which causes synovial cell invasion into the bone and cartilage. In RA pathogenesis,...
Citation: Inflammation and Regeneration 2021 41:7 -
Elucidation of disease etiology by trans-layer omics analysis
To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...
Citation: Inflammation and Regeneration 2021 41:6