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Advances in in vitro modeling of the blood-brain barrier and neurovascular unit

© John J. Jamieson et al., 2019

In this thematic issue, Fluids and Barriers of the CNS aims to bring together papers related to in vitro modeling of the blood-brain barrier and the neurovascular unit (NVU). In recent years, major advances have been made in the field including the use of brain endothelial cells derived from human induced pluripotent stem cells, NVU models composed of multiple cell types, and the development of novel 3D models, including the use of microchips. Such advances are increasing our understanding of barrier function and intercellular crosstalk in health and disease, identification of therapeutic targets, and methods for high-throughput screenings of drugs for treatment of neurological diseases. 

We are welcoming submissions that address advances in in vitro modeling, including original research, reviews and commentaries (e.g. on future directions). Papers can address the utility and limitations of such models in relation to BBB physiology, pathophysiology and pharmacology.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Submission deadline: February 1st, 2020.

To submit your work, please use the online submission system and select the name of the series when completing the additional information section of the submission form.

Examples of relevant work recently published by Fluids and Barriers of the CNS include:

  1. Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NV...

    Authors: Michelle A. Erickson, Miranda L. Wilson and William A. Banks

    Citation: Fluids and Barriers of the CNS 2020 17:26

    Content type: Review

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  2. The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its functional and structural integrity is vital in maintaining the homeostasis of the brain microenvironment. On the oth...

    Authors: Aditya Bhalerao, Farzane Sivandzade, Sabrina Rahman Archie, Ekram Ahmed Chowdhury, Behnam Noorani and Luca Cucullo

    Citation: Fluids and Barriers of the CNS 2020 17:22

    Content type: Review

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  3. The blood–brain barrier (BBB) is altered in several diseases of the central nervous system. For example, the breakdown of the BBB during cerebral ischemia in stroke or traumatic brain injury is a hallmark of t...

    Authors: Anna Gerhartl, Nadja Pracser, Alexandra Vladetic, Sabrina Hendrikx, Heinz-Peter Friedl and Winfried Neuhaus

    Citation: Fluids and Barriers of the CNS 2020 17:19

    Content type: Research

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  4. The endothelial cell–cell junctions of the blood–brain barrier (BBB) play a pivotal role in the barrier’s function. Altered cell–cell junctions can lead to barrier dysfunction and have been implicated in sever...

    Authors: Kelsey M. Gray, Jae W. Jung, Collin T. Inglut, Huang-Chiao Huang and Kimberly M. Stroka

    Citation: Fluids and Barriers of the CNS 2020 17:16

    Content type: Research

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  5. The brain barriers establish compartments in the central nervous system (CNS) that significantly differ in their communication with the peripheral immune system. In this function they strictly control T-cell e...

    Authors: Hideaki Nishihara, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten, Fabien Gosselet and Britta Engelhardt

    Citation: Fluids and Barriers of the CNS 2020 17:3

    Content type: Research

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  6. Blood–brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to...

    Authors: Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2019 16:20

    Content type: Research

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  7. Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential ...

    Authors: Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang and Joel S. Pachter

    Citation: Fluids and Barriers of the CNS 2019 16:18

    Content type: Research

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  8. Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet. Despite the direct cell–cell contact observed in v...

    Authors: John J. Jamieson, Raleigh M. Linville, Yuan Yuan Ding, Sharon Gerecht and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2019 16:15

    Content type: Research

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  9. Brain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals...

    Authors: Andrea E. Toth, Simone S. E. Nielsen, Weronika Tomaka, N. Joan Abbott and Morten S. Nielsen

    Citation: Fluids and Barriers of the CNS 2019 16:14

    Content type: Research

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