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Update on Amyotrophic lateral sclerosis: from genetic and mitochondria perspective

Edited by Shengdi Chen and Jialin Zheng

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Approximately 5-10% of ALS patients are inherited ALS, which is caused by as much as 24 mutated genes. Prof. Yukio Ando provides a comprehensive, up-to-date review of major ALS gene mutations and suggests algorithms for genetic testing based on age at onset. ALS has a devastating nature and is incurable. Prof. Wang and his colleagues provide a comprehensive review of mitochondrial dynamics abnormalities in ALS and suggest that mitochondrial dynamics can be used as therapeutic targets of ALS. Readers will gain the latest and most helpful information from this thematic series. 

Last updated on 30 September 2015

  1. Content type: Review

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Authors: Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Citation: Translational Neurodegeneration 2015 4:14

    Published on:

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