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Clinical and translational research on ALDH2 deficiency associated diseases

Edited by Dr Tse-Hua Tan

A thematic series in Journal of Biomedical Science.

  1. The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen
    Citation: Journal of Biomedical Science 2017 24:33
    Content type: Research Published on:

  3. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxi...

    Authors: Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz and Daria Mochly-Rosen
    Citation: Journal of Biomedical Science 2017 24:3
    Content type: Research Published on:

  4. Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (

    Authors: Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R. Gross, Daria Mochly-Rosen and Yasuki Kihara
    Citation: Journal of Biomedical Science 2016 23:89
    Content type: Research Published on:

  5. The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a...

    Authors: Stacy L. McAllister, Katherine Sun and Eric R. Gross
    Citation: Journal of Biomedical Science 2016 23:80
    Content type: Review Published on: