Guest Editors
Joris Deelen, Max Planck Institute for Biology of Ageing, Germany
Henne Holstege, Amsterdam UMC, The Netherlands
Genome Medicine is calling for submissions to a new Collection on advances in healthy aging and age-related diseases, guest edited by Joris Deleen and Henne Holstege.
Genome Medicine is calling for submissions to a new Collection on advances in healthy aging and age-related diseases.
As global demographics shift towards an aging population, biomedical sciences are confronted with novel challenges having to do with higher life expectancy, deterioration of health, and increased prevalence of disease. There is an unprecedented need to understand the mechanisms of aging, a complex multi-faceted process, in order to create progress towards anti-aging interventions and to prolong health span and well-being during the aging process.
This Collection aims at gathering innovative contributions that advance our understanding of the biological, molecular and medical implications of aging and their intricate interplay with well-being and age-related diseases. We encourage contributions that span a spectrum of disciplines, including but not limited to genetics, omics, biogerontology, epidemiology, research in model organisms and clinical research.
Topics of interest for this collection include, but are not limited to:
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Joris Deelen, Max Planck Institute for Biology of Ageing, Germany
Joris Deelen is a Research Group Leader at the Max Planck Institute for Biology Ageing in Germany. The primary aim of the research in Dr Deelen’s group is to study the effect of rare protein-altering genetic variants that they and their collaborators identified using whole-genome/exome sequencing data of long-lived individuals. To this end, they make use of the CRISPR/Cas9 system to generate transgenic cell lines and mice harboring the identified variants. They subsequently measure the in vitro (human and mouse cell lines) and in vivo (mice) effects of the genetic variants on the functioning of the genes in which they reside. The second aim of his research group is to integrate previously identified biomarkers of healthy aging, with the primary focus on metabolites, in novel studies initiated at the Cologne University Hospital to determine their efficacy in clinical settings.
Henne Holstege, UMC Amsterdam, The Netherlands
Henne Holstege majored in biochemistry at the University of Leiden, The Netherlands. During her studies, she spent a year at Harvard University in Boston, where she investigated the molecular mechanisms of satiety. She did her PhD at the Netherlands Cancer Institute where she studied the somatic genetic aberrations associated with the development of breast cancer. After her PhD she applied her knowledge of molecular genetics to study the genetic factors underlying the increased risk of cognitive decline, but also those that increase the chance to maintain high levels of cognitive function while achieving extreme ages. Currently, Henne Holstege is an associate professor at the department of Human Genetics of the Amsterdam University Medical Center where she runs an independent research section: Genomics of Neurodegenerative Diseases and Aging. She is a staff-member of the Amsterdam Alzheimer Center and she is affiliated with the Delft Bioinformatics Lab of Technical University Delft.
Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery....
The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not entirely known. We aimed to investigate the causal role of circulating metabo...
This Collection welcomes submission of Research, Method, Software, Database, and Guideline articles. Before submitting your manuscript, please ensure you have read our submission guidelines.
Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Advances in healthy aging and age-related disease" from the dropdown menu.
You are welcome to enquire about the suitability of your manuscript by emailing our editorial office at editorial@genomemedicine.com.
All articles submitted to Collections are peer reviewed in line with the journal’s standard peer review policy and are subject to all of the journal’s standard editorial and publishing policies. This includes the journal’s policy on competing interests.
The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editor or Editorial Board Member who has no competing interests.