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Aging and inflammation

Guest edited by Issei Komuro

A thematic series in Inflammation and Regeneration.

This series of articles has not been sponsored. All articles have undergone the journal's standard peer review process overseen by the Guest Editor. The Guest Editor declares no competing interests.

  1. Review

    Dissecting cellular senescence and SASP in Drosophila

    Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Takao Ito and Tatsushi Igaki

    Inflammation and Regeneration 2016 36:25

    Published on: 5 December 2016

  2. Review

    Age-related sarcopenia and its pathophysiological bases

    Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, includin...

    Sumito Ogawa, Mitsutaka Yakabe and Masahiro Akishita

    Inflammation and Regeneration 2016 36:17

    Published on: 7 September 2016

  3. Review

    The pathological role of vascular aging in cardio-metabolic disorder

    Chronological aging is linked to cellular senescence, and there is accumulating evidence for a pathological role of cellular senescence in age-related disorders such as obesity, diabetes, and heart failure. Th...

    Goro Katsuumi, Ippei Shimizu, Yohko Yoshida and Tohru Minamino

    Inflammation and Regeneration 2016 36:16

    Published on: 16 August 2016

  4. Review

    Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes

    The renin-angiotensin system (RAS) regulates diverse cellular responses and is crucial for normal organ development and function. On the other hand, RAS exerts deleterious effects promoting cardiovascular and ...

    Takehiro Kamo, Hiroshi Akazawa, Jun-ichi Suzuki and Issei Komuro

    Inflammation and Regeneration 2016 36:12

    Published on: 9 August 2016

  5. Review

    RANKL system in vascular and valve calcification with aging

    Vascular and cardiac valve calcification is associated with cardiovascular mortality in the general population. Increasing clinical and experimental evidence suggests that inflammation accelerates the progress...

    Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori, Masakazu Kohno and Ryuichi Morishita

    Inflammation and Regeneration 2016 36:10

    Published on: 1 August 2016