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Alzheimer's Disease: Challenges for the next decade

Neuron cell system shown in blue

  1. Alzheimer’s disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates. To aid in research efforts...

    Authors: Brittany S. Ulm, David R. Borchelt and Brenda D. Moore

    Citation: Molecular Neurodegeneration 2021 16:8

    Content type: Review

    Published on:

  2. Successful development of agents that improve cognition and behavior in Alzheimer’s disease (AD) is critical to improving the lives of patients manifesting the symptoms of this progressive disorder.

    Authors: Jeffrey Cummings

    Citation: Molecular Neurodegeneration 2021 16:2

    Content type: Review

    Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2021 16:21

  3. Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer’s disease (AD), have yielded significant insights into the pathogenic mechanism. Among the three common coding variant...

    Authors: Zonghua Li, Francis Shue, Na Zhao, Mitsuru Shinohara and Guojun Bu

    Citation: Molecular Neurodegeneration 2020 15:63

    Content type: Review

    Published on:

  4. Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the Alzheimer’s disease (AD) continuum. Investigating populations with SCD is important for understanding the early patholo...

    Authors: Xiaoqi Wang, Weijie Huang, Li Su, Yue Xing, Frank Jessen, Yu Sun, Ni Shu and Ying Han

    Citation: Molecular Neurodegeneration 2020 15:55

    Content type: Review

    Published on:

  5. Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It ...

    Authors: Hannah R. Bulgart, Evan W. Neczypor, Loren E. Wold and Amy R. Mackos

    Citation: Molecular Neurodegeneration 2020 15:42

    Content type: Review

    Published on:

  6. Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear under...

    Authors: Tiantian Guo, Denghong Zhang, Yuzhe Zeng, Timothy Y. Huang, Huaxi Xu and Yingjun Zhao

    Citation: Molecular Neurodegeneration 2020 15:40

    Content type: Review

    Published on:

  7. Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain. Under the microscope, neuronal ac...

    Authors: Wenzhang Wang, Fanpeng Zhao, Xiaopin Ma, George Perry and Xiongwei Zhu

    Citation: Molecular Neurodegeneration 2020 15:30

    Content type: Review

    Published on:

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