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Five years of Trials

A thematic series published in Trials.

  1. Research

    The International Stroke Trial database

    We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of ...

    Peter AG Sandercock, Maciej Niewada and Anna Członkowska

    Trials 2011 12:101

    Published on: 21 April 2011

    The Erratum to this article has been published in Trials 2012 13:24

  2. Research

    Ethical issues posed by cluster randomized trials in health research

    The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing...

    Charles Weijer, Jeremy M Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Antonio Gallo, Andrew D McRae, Raphael Saginur and Merrick Zwarenstein

    Trials 2011 12:100

    Published on: 20 April 2011

  3. Study protocol

    CRIMSON [CRisis plan IMpact: Subjective and Objective coercion and eNgagement] Protocol: A randomised controlled trial of joint crisis plans to reduce compulsory treatment of people with psychosis

    The use of compulsory treatment under the Mental Health Act (MHA) has continued to rise in the UK and in other countries. The Joint Crisis Plan (JCP) is a statement of service users' wishes for treatment in th...

    Graham Thornicroft, Simone Farrelly, Max Birchwood, Max Marshall, George Szmukler, Waquas Waheed, Sarah Byford, Graham Dunn, Claire Henderson, Helen Lester, Morven Leese, Diana Rose and Kim Sutherby

    Trials 2010 11:102

    Published on: 5 November 2010

  4. Review

    Reporting bias in medical research - a narrative review

    Reporting bias represents a major problem in the assessment of health care interventions. Several prominent cases have been described in the literature, for example, in the reporting of trials of antidepressan...

    Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch and Thomas Kaiser

    Trials 2010 11:37

    Published on: 13 April 2010

  5. Research

    N-acetylcysteine does not prevent contrast-induced nephropathy after cardiac catheterization in patients with diabetes mellitus and chronic kidney disease: a randomized clinical trial

    Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) constitute to be a high-risk population for the development of contrast-induced nephropathy (CIN), in which the incidence of CIN is estimat...

    Manouchehr Amini, Mojtaba Salarifar, Alireza Amirbaigloo, Farzad Masoudkabir and Fatemeh Esfahani

    Trials 2009 10:45

    Published on: 29 June 2009