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Five years of Trials

A thematic series published in Trials.

  1. Content type: Research

    We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of ...

    Authors: Peter AG Sandercock, Maciej Niewada and Anna Członkowska

    Citation: Trials 2011 12:101

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    The Erratum to this article has been published in Trials 2012 13:24

  2. Content type: Research

    The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing...

    Authors: Charles Weijer, Jeremy M Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Antonio Gallo, Andrew D McRae, Raphael Saginur and Merrick Zwarenstein

    Citation: Trials 2011 12:100

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  3. Content type: Research

    The trial on endovascular management of unruptured intracranial aneurysms (TEAM), a prospective randomized trial comparing coiling and conservative management, initiated in September 2006, was stopped in June ...

    Authors: Jean Raymond, Tim E Darsaut and Andrew J Molyneux

    Citation: Trials 2011 12:64

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  4. Content type: Study protocol

    The use of compulsory treatment under the Mental Health Act (MHA) has continued to rise in the UK and in other countries. The Joint Crisis Plan (JCP) is a statement of service users' wishes for treatment in th...

    Authors: Graham Thornicroft, Simone Farrelly, Max Birchwood, Max Marshall, George Szmukler, Waquas Waheed, Sarah Byford, Graham Dunn, Claire Henderson, Helen Lester, Morven Leese, Diana Rose and Kim Sutherby

    Citation: Trials 2010 11:102

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  5. Content type: Study protocol

    Thrombolysis with intravenous rt-PA is currently the only approved acute therapy for ischemic stroke. Re-occlusion after initial recanalization occurs in up to 34% in patients treated with rt-PA, probably caus...

    Authors: SM Zinkstok, M Vermeulen, J Stam, RJ de Haan and YB Roos

    Citation: Trials 2010 11:51

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  6. Content type: Review

    Reporting bias represents a major problem in the assessment of health care interventions. Several prominent cases have been described in the literature, for example, in the reporting of trials of antidepressan...

    Authors: Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch and Thomas Kaiser

    Citation: Trials 2010 11:37

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  7. Content type: Editorial

    In recognition of the benefits of transparent reporting, many peer-reviewed journals require that their authors be prepared to share their raw, unprocessed data with other scientists and/or state the availabil...

    Authors: Iain Hrynaszkiewicz, Melissa L Norton, Andrew J Vickers and Douglas G Altman

    Citation: Trials 2010 11:9

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  8. Content type: Research

    Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) constitute to be a high-risk population for the development of contrast-induced nephropathy (CIN), in which the incidence of CIN is estimat...

    Authors: Manouchehr Amini, Mojtaba Salarifar, Alireza Amirbaigloo, Farzad Masoudkabir and Fatemeh Esfahani

    Citation: Trials 2009 10:45

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