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Liquid Biopsy at the Frontier of Early Detection, Prognosis and Cancer Treatments

urzine / Getty Images / iStock © urzine / Getty Images / iStock

Liquid biopsies rely upon detection of circulating tumor cells, cell free DNA, RNA, proteins, lipids, and metabolites present in biofluids of patients. These biospecimens can be easily and reproducibly collected for analyses. The rapid advances in sequencing technologies have further helped the development of FDA-approved liquid biopsies companion diagnostic tests used by clinicians.  

This special issue published by Molecular Cancer focuses on the clinical aspects of liquid biopsies, in particular validation of novel biomarkers that may serve as signature for non-invasive early detection of cancerous cells, predict patients' risks of disease progression and response to specific therapies.

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