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Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

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Guest Editors: George A. Calin1Silvia Di Agostino2Sara Donzelli3

1- MD Anderson Cancer Center, Houston, Texas, USA
2- Magna Græcia University, Catanzaro, Italy
3- Regina Elena National Cancer Institute, Rome, Italy

Submission window: January 1st 2022 – December 31st 2022. Submit your research here.

In the last twenty years, thanks to the enormous development of technology and sequencing techniques, many advances have been made in the treatment of cancer, mainly aimed at precision therapies. However, many types of tumors are incurable when diagnosed late and still lacking in precision therapies and resistant to the usual therapies. Primary tumors that manage to be cured are often projected towards a destiny of recurrence and metastasis, study frontiers still open. In light of these considerations, new biomarkers are still needed for diagnosis, tumor characterization and new targets for cancer treatments. Among the most promising biomarkers and potential targets against cancer, non-coding RNA (ncRNA) are the most likely to have rapid translational application. Their characteristics of high stability and secretion in human fluids make them robust biomarkers.

MicroRNAs (miRNAs) are undoubtedly the most studied and about them, there are already active clinical trials as therapeutic targets. However, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), promising like miRNAs, are still molecules to be investigated and validated as biomarkers.

Keywords: LncRNAs, CircRNAs, Biomarkers, Tumorigenesis, Metastasis, Invasion, Epithelial-to-mesenchymal transition (EMT), Drug resistance, Therapy, Therapeutic target, Liquid biopsy.

In this Special Issue of Journal of Experimental & Clinical Cancer Research, we would like to give space to studies that highlight lncRNAs and circRNAs as possible markers of prognosis, diagnosis, drug resistance and metastasis processes in solid and hematopoietic tumors, including studies that develop new molecular, statistical and computational tools for their identification, without forgetting their functional characterization in the various aspects of oncological activities.

Note: As a pre-acceptance check, the journal reserves the right to ask the authors to provide the editors with any raw data and ethics approval documents.

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