Skip to main content


10th Anniversary Collection

Since its launch in 2004, Journal of Neuroinflammation has established itself as a premier destination for research focused on innate immunological responses of the nervous system. We are celebrating our success over the last ten years with a series of exciting reviews that mark key accomplishments within the field over this period, whilst also looking forward to advances on the horizon.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

View all collections published in Journal of Neuroinflammation

  1. Review

    Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

    An increasing number of studies show that the activation of the innate immune system and inflammatory mechanisms play an important role in the pathogenesis of numerous diseases. The innate immune system is pre...

    Giorgio Santoni, Claudio Cardinali, Maria Beatrice Morelli, Matteo Santoni, Massimo Nabissi and Consuelo Amantini

    Journal of Neuroinflammation 2015 12:21

    Published on: 3 February 2015

  2. Review

    Should development of Alzheimer’s disease-specific intravenous immunoglobulin be considered?

    Recent phase II and III studies with intravenous immunoglobulin (IVIG) in patients with Alzheimer’s disease (AD) did not find evidence for the slowing of AD progression compared to placebo-treated patients, in...

    David A Loeffler

    Journal of Neuroinflammation 2014 11:198

    Published on: 5 December 2014

    The Erratum to this article has been published in Journal of Neuroinflammation 2015 12:68

  3. Review

    Calcineurin and glial signaling: neuroinflammation and beyond

    Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation. Several studies suggest that har...

    Jennifer L Furman and Christopher M Norris

    Journal of Neuroinflammation 2014 11:158

    Published on: 10 September 2014

  4. Review

    Neutrophil contribution to spinal cord injury and repair

    Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant import...

    Virginie Neirinckx, Cécile Coste, Rachelle Franzen, André Gothot, Bernard Rogister and Sabine Wislet

    Journal of Neuroinflammation 2014 11:150

    Published on: 28 August 2014

  5. Review

    Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging

    Alzheimer’s disease (AD) has been reconceptualized as a dynamic pathophysiological process, where the accumulation of amyloid-beta (Aβ) is thought to trigger a cascade of neurodegenerative events resulting in ...

    Eduardo Rigon Zimmer, Antoine Leuzy, Andréa Lessa Benedet, John Breitner, Serge Gauthier and Pedro Rosa-Neto

    Journal of Neuroinflammation 2014 11:120

    Published on: 8 July 2014

  6. Review

    Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

    The concept of multiple macrophage activation states is not new. However, extending this idea to resident tissue macrophages, like microglia, has gained increased interest in recent years. Unfortunately, the r...

    Jonathan D Cherry, John A Olschowka and M Kerry O’Banion

    Journal of Neuroinflammation 2014 11:98

    Published on: 3 June 2014

  7. Review

    Exosomes as mediators of neuroinflammation

    Exosomes are membrane-bound nanovesicles that are shed by cells of various lineages under normal as well as pathological conditions. Previously thought to be ‘extracellular debris’, exosomes have recently gene...

    Archana Gupta and Lynn Pulliam

    Journal of Neuroinflammation 2014 11:68

    Published on: 3 April 2014

  8. Review

    LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

    It is now well established that chronic inflammation is a prominent feature of several neurodegenerative disorders including Parkinson’s disease (PD). Growing evidence indicates that neuroinflammation can cont...

    Isabella Russo, Luigi Bubacco and Elisa Greggio

    Journal of Neuroinflammation 2014 11:52

    Published on: 21 March 2014

  9. Review

    Inflammation-sleep interface in brain disease: TNF, insulin, orexin

    The depth, pattern, timing and duration of unconsciousness, including sleep, vary greatly in inflammatory disease, and are regarded as reliable indicators of disease severity. Similarly, these indicators are a...

    Ian A Clark and Bryce Vissel

    Journal of Neuroinflammation 2014 11:51

    Published on: 21 March 2014

  10. Review

    Modulation of inflammation in transgenic models of Alzheimer’s disease

    Over the past decade the process of inflammation has been a focus of increasing interest in the Alzheimer’s disease (AD) field, not only for its potential role in neuronal degeneration but also as a promising ...

    Amy M Birch, Loukia Katsouri and Magdalena Sastre

    Journal of Neuroinflammation 2014 11:25

    Published on: 3 February 2014

  11. Review

    MIF: Mood Improving/Inhibiting Factor?

    Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiolo...

    Joshua Bloom and Yousef Al-Abed

    Journal of Neuroinflammation 2014 11:11

    Published on: 21 January 2014