Open Access Open Badges Study protocol

Estimation of transient increases in bleeding risk associated with physical activity in children with haemophilia

Carolyn R Broderick123*, Robert D Herbert3, Jane Latimer3, Chris Barnes4, Julie A Curtin5 and Paul Monagle46

Author Affiliations

1 School of Medical Sciences, University of New South Wales, Randwick NSW 2052, Australia

2 Children's Hospital Institute of Sports Medicine, The Children's Hospital at Westmead, Westmead NSW 2145, Australia

3 The George Institute for International Health, Camperdown NSW 2050, Australia

4 Department of Haematology Royal Children's Hospital, Parkville VIC 3052, Australia

5 Department of Haematology, The Children's Hospital at Westmead, Westmead NSW 2145, Australia

6 Department of Pathology, University of Melbourne Parkville, VIC 3052, Australia

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BMC Blood Disorders 2008, 8:2  doi:10.1186/1471-2326-8-2

Published: 26 June 2008



Although it is widely appreciated that vigorous physical activity can increase the risk of bleeding episodes in children with haemophilia, the magnitude of the increase in risk is not known. Accurate risk estimates could inform decisions made by children with haemophilia and their parents about participation in physical activity and aid the development of optimal prophylactic schedules. The aim of this study is to provide an accurate estimate of the risks of bleeding associated with vigorous physical activity in children with haemophilia.


The study will be a case-crossover study nested within a prospective cohort study. Children with moderate or severe haemophilia A or B, recruited from two paediatric haematology departments in Australia, will participate in the study. The child, or the child's parent or guardian, will report bleeding episodes experienced over a 12-month period. Following a bleeding episode, the participant will be interviewed by telephone about exposures to physical activity in the case period (8 hours before the bleed) and 2 control periods (an 8 hour period at the same time on the day preceding the bleed and an 8 hour period two days preceding the bleed). Conditional logistic regression will be used to estimate the risk of participating in vigorous physical activity from measures of exposure to physical activity in the case and control periods.


This case-control study will provide estimates of the risk of participation in vigorous physical activity in children with haemophilia.