This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.
Harin Karunajeewa comments on research identifying determinants of early parasite clearance following artemisinin-based malaria treatment, highlighting that the findings should enable early detection of artemisinin resistance in African populations.
Evidence from meta-analyses suggests that some commonly-used drugs show only minimal clinically important benefits, indicating that physician training may be required to prevent overtreatment and emphasize evidence-based medicine.
Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing
Work on primordial dwarfism provides new insights into links between tRNA modification and inherited conditions in humans
The number of articles published in open access journals with questionable marketing and peer review practices, has increased by nearly eight times since 2010 and authors are predominantly based in Asia and Africa.
Nick Golding and colleagues propose that combined vector control in low resource settings is an effective strategy due to overlapping distributions of disease, highlighting the benefit of investing in such measures in these settings.
In an analysis using Benefit-Harm Charts, low dose aspirin is beneficial for men, elderly people and those at low bleeding risk, highlighting the importance of individualized benefit-harm assessments for the prevention of cardiovascular disease and cancer.
In patients with rheumatoid arthritis (RA), the presence of serum survivin is associated with poor outcome following methotrexate (MTX) treatment, suggesting that measurement of survivin could be useful for treatment planning in early RA.
There is variation in adherence to national recommendations for bipolar disorder care in England and Wales; Richard Morriss discusses barriers to guideline implementation, and advocates that following national guidance should be mandatory.
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