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  • Seizures in an immunocompromised youth

    Immunocompromised patients are at higher risk of contracting tuberculosis with atypical presentations. A 17 year-old man presented with focal fits progressing to epilepsia partialis continua. Mycobacterium tuberculosis was detected in the cerebrospinal fluid and successfully treated.

    Journal of Medical Case Reports 2015, 9:184
  • Predicting chromatin compartments

    A method for predicting a sequence’s localization in the A or B compartment of the nucleus based on chromatin data

    Genome Biology 2015, 16:180
  • Towards personalised radiation therapy

    Part of a series on bioinformatics and systems biology in radiation oncology, this review looks at the promise of next-generation sequencing for developing personalised cancer treatment strategies.

    Radiation Oncology 2015, 10:183
  • Image attributed to: flickr; doviende

    ADHD linked to mathematical ability

    In a systematic review, the inattentive component of attention deficit/hyperactivity disorder (ADHD) has a stronger negative association with mathematical ability than the hyperactive component, highlighting that ADHD domains could have differential etiology.

    BMC Medicine 2015, 13:204
  • Image attributed to: From Fig 1 Pelletier and colleagues

    DNA-PK inhibition boosts Cas9-mediated HDR

    Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.

    Genome Medicine 2015, 7:93
  • Image attributed to: Figure 6

    3D plant cell culture

    A new technique borrows from biomedical engineering to study plant cells in culture conditions that mimic tissue scaffolds, allowing for a more physiologically relevant way to explore cell-environment interactions.

    BMC Plant Biology 2015, 15:211
  • In-nucleus ligation Hi-C

    A comparison of in-nucleus and in-solution ligation protocols for Hi-C finds that the former gives much more consistent results

    Genome Biology 2015, 16:175
  • RF associated with higher RA disease scores

    The presence of rheumatoid factor (RF) has a clear association with high levels of disease activity in rheumatoid arthritis (RA) patients whereas autoantibodies against citrullinated proteins (APCA), the characteristic marker, does not.

    Arthritis Research & Therapy 2015, 17:229
  • Barley domestication

    Robin Allaby discusses the origins of barley, and what this means for our understanding of the evolution of domesticated crops

    Genome Biology 2015, 16:176
  • Astrocytes in the sleeping and awake brain

    Does the state of the brain - whether asleep, awake, or sleep-deprived - affect astrocytes (or vice versa)? Profiling of ribosome-associated mRNAs identifies changes in gene expression, while 3-d imaging at nanometer resolution reveals a retraction of astrocytic processes from neural synapses during sleep.

    BMC Biology 2015, 13:66
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