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  • Image attributed to: NIAID CC2.0

    Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
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    Monitoring antimalarial resistance

    Harin Karunajeewa comments on research identifying determinants of early parasite clearance following artemisinin-based malaria treatment, highlighting that the findings should enable early detection of artemisinin resistance in African populations.

    BMC Medicine 2015, 13:251
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    Are common medications effective?

    Evidence from meta-analyses suggests that some commonly-used drugs show only minimal clinically important benefits, indicating that physician training may be required to prevent overtreatment and emphasize evidence-based medicine.

    BMC Medicine 2015, 13:253
  • XIST and localization

    Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing

    Genome Biology 2015, 16:208
  • tRNAs and inherited conditions

    Work on primordial dwarfism provides new insights into links between tRNA modification and inherited conditions in humans

    Genome Biology 2015, 16:216
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    Increased volume of ‘questionable’ articles

    The number of articles published in open access journals with questionable marketing and peer review practices, has increased by nearly eight times since 2010 and authors are predominantly based in Asia and Africa.

    BMC Medicine 2015, 13:230
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    Cross-disease vector control 

    Nick Golding and colleagues propose that combined vector control in low resource settings is an effective strategy due to overlapping distributions of disease, highlighting the benefit of investing in such measures in these settings. 

    BMC Medicine 2015, 13:249
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    Aspirin beneficial in specific groups

    In an analysis using Benefit-Harm Charts, low dose aspirin is beneficial for men, elderly people and those at low bleeding risk, highlighting the importance of individualized benefit-harm assessments for the prevention of cardiovascular disease and cancer. 

    BMC Medicine 2015, 13:250
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    Survivin associated with MTX response

    In patients with rheumatoid arthritis (RA), the presence of serum survivin is associated with poor outcome following methotrexate (MTX) treatment, suggesting that measurement of survivin could be useful for treatment planning in early RA.

    BMC Medicine 2015, 13:247
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    Guidelines for bipolar care

    There is variation in adherence to national recommendations for bipolar disorder care in England and Wales; Richard Morriss discusses barriers to guideline implementation, and advocates that following national guidance should be mandatory.

    BMC Medicine 2015, 13:246
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