Palvimo and colleagues demonstrate that SUMOylation of chromatin-bound proteins represses heat shock-induced gene transcription
The involvement of BRCA1 and BRCA2 in breast and ovarian cancers is widely recognised; Helen Cavanagh and Katherine Rogers review the evidence for the role of BRCA1/2 in other cancer types.
A score derived from the Fluid As Expansive Supportive Therapy (FEAST) trial can be used for emergency triage in a low-income pediatric setting, which could increase the number of hospitals in such settings that successfully implement the triage process.
A combination of low birth weight and unhealthy lifestyle is more strongly associated with hypertension risk than either variable alone, indicating that prenatal and postnatal factors could influence hypertension risk.
Jennifer Gardy, Nick Loman and Andrew Rambaut's call to arms: new technologies should be better used to aid public health surveillance
In an analysis of incidence and mortality rates in England, Black men are at double the risk of prostate cancer diagnosis and death compared with those of other ethnicities, providing information to help men better understand their prostate cancer risk
Jeffrey Gagan and Eliezer Van Allen review how next-generation sequencing can be incorporated into standard oncology clinical practice and provide guidance on the potential and limitations of sequencing.
Evidence from a systematic review suggests that perceptions of generic medicines have improved, and acceptance is greater in those with higher levels of education, suggesting that provision of information is necessary to promote acceptance of these drugs.
In a mathematical model, the RTS,S/AS01 malaria vaccine is predicted to provide high initial efficacy but declining protection over time in 11 African sites, suggesting that adding RTS,S should be added to existing malaria control programs to reduce deaths.
A platform for managing clinical exome sequencing data that includes data entry, distribution of work assignments, variant evaluation and review, selection of variants for validation, report generation.
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