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  • Global chromatin SUMOylation

    Palvimo and colleagues demonstrate that SUMOylation of chromatin-bound proteins represses heat shock-induced gene transcription

    Genome Biology 2015, 16:153
  • BRCA1/2 in prostate, pancreatic and stomach cancers

    The involvement of BRCA1 and BRCA2 in breast and ovarian cancers is widely recognised; Helen Cavanagh and Katherine Rogers review the evidence for the role of BRCA1/2 in other cancer types.

    Hereditary Cancer in Clinical Practice 2015, 13:16
  • Image attributed to: Flickr CC (DFID UK)

    FEAST score is useful for triage

    A score derived from the Fluid As Expansive Supportive Therapy (FEAST) trial can be used for emergency triage in a low-income pediatric setting, which could increase the number of hospitals in such settings that successfully implement the triage process.

    BMC Medicine 2015, 13:174
  • Image attributed to: Flickr, Medisave UK

    Birth weight linked to hypertension risk

    A combination of low birth weight and unhealthy lifestyle is more strongly associated with hypertension risk than either variable alone, indicating that prenatal and postnatal factors could influence hypertension risk.

    BMC Medicine 2015, 13:175
  • Real-time pathogen surveillance

    Jennifer Gardy, Nick Loman and Andrew Rambaut's call to arms: new technologies should be better used to aid public health surveillance

    Genome Biology 2015, 16:155
  • Image attributed to: Wikipedia; Nightbolt

    Black men have higher prostate cancer risk

    In an analysis of incidence and mortality rates in England, Black men are at double the risk of prostate cancer diagnosis and death compared with those of other ethnicities, providing information to help men better understand their prostate cancer risk

    BMC Medicine 2015, 13:171
  • Image attributed to: From Fig 4 Van Allen and colleagues

    NGS-guided cancer therapy

    Jeffrey Gagan and Eliezer Van Allen review how next-generation sequencing can be incorporated into standard oncology clinical practice and provide guidance on the potential and limitations of sequencing.

    Genome Medicine 2015, 7:80
  • Image attributed to: Pixabay

    How are generic medicines perceived?

    Evidence from a systematic review suggests that perceptions of generic medicines have improved, and acceptance is greater in those with higher levels of education, suggesting that provision of information is necessary to promote acceptance of these drugs.

    BMC Medicine 2015, 13:173
  • Image attributed to: istock photo

    RTS,S vaccine provides high initial efficacy

    In a mathematical model, the RTS,S/AS01 malaria vaccine is predicted to provide high initial efficacy but declining protection over time in 11 African sites, suggesting that adding RTS,S should be added to existing malaria control programs to reduce deaths.

    BMC Medicine 2015, 13:170
  • Image attributed to: From Fig 3 Chen and colleagues


    A platform for managing clinical exome sequencing data that includes data entry, distribution of work assignments, variant evaluation and review, selection of variants for validation, report generation.

    Genome Medicine 2015, 7:77
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