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Genes, animal models and the current understanding of psychiatric disease

Penelope Austin BMC Biology 2011, 9:78 (11 November 2011)

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Two articles in our Wiring the Brain series explore the implications of new genetic information on psychiatric disease for clinical practice and for elucidation of the complex biology of disorders of the mind. Penelope Austin explains the two points of view they reflect.

Two patients walk into a clinic...a genomics perspective on the future of schizophrenia

Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011)

How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.

Following the genes: a framework for animal modeling of psychiatric disorders

Kevin J Mitchell, Z Josh Huang, Bita Moghaddam, Akira Sawa BMC Biology 2011, 9:76 (11 November 2011)

Following a brief overview of the revolution in psychiatric genetics, Kevin Mitchell and colleagues explain how the effects of causal mutations can be studied in animals to elucidate pathogenic mechanisms and neurobiological phenotypes of direct relevance to human disease.

Machine learning for neuroscience

Geoffrey E Hinton Neural Systems & Circuits 2011, 1:12 (15 August 2011)

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The miswired brain: making connections from neurodevelopment to psychopathology

Kevin J Mitchell BMC Biology 2011, 9:23 (12 April 2011)

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In a brief comment, Kevin Mitchell discusses the implications of the convergence of neuropsychiatric genetics on genes involved in neurodevelopment, outlining the challenge of linking the primary mutations to the final pathology, and explaining how mouse models can help.

Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

Claude M Schofield, Ruby Hsu, Alison J Barker, Caitlyn C Gertz, Robert Blelloch, Erik M Ullian Neural Development 2011, 6:11 (5 April 2011)

Abstract | Full text | PDF | PubMed

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

John P Hussman, Ren-Hua Chung, Anthony J Griswold, James M Jaworski, Daria Salyakina, Deqiong Ma, Ioanna Konidari, Patrice L Whitehead, Jeffery M Vance, Eden R Martin, Michael L Cuccaro, John R Gilbert, Jonathan L Haines, Margaret A Pericak-Vance Molecular Autism 2011, 2:1 (19 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype

Noelle D Dwyer, Danielle K Manning, Jennifer L Moran, Raksha Mudbhary, Michael S Fleming, Carlita B Favero, Vita M Vock, Dennis DM O'Leary, Christopher A Walsh, David R Beier Neural Development 2011, 6:3 (7 January 2011)

Abstract | Full text | PDF | PubMed

Screening for genes that wire the cerebral cortex

Ludmilla Lokmane, Sonia Garel BMC Biology 2011, 9:1 (7 January 2011)

Commenting on a paper in Neural Development, Ludmilla Lokmane and Sonia Garel explain how this has demonstrated the feasibility of a forward genetic approach to understanding mammalian brain morphogenesis and wiring.

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Ozlem Bozdagi, Takeshi Sakurai, Danae Papapetrou, Xiaobin Wang, Dara L Dickstein, Nagahide Takahashi, Yuji Kajiwara, Mu Yang, Adam M Katz, Maria Scattoni, Mark J Harris, Roheeni Saxena, Jill L Silverman, Jacqueline N Crawley, Qiang Zhou, Patrick R Hof, Joseph D Buxbaum Molecular Autism 2010, 1:15 (17 December 2010)

Recent discovery may explain how mutations affecting SHANK3 may lead to autism spectrum disorders

Video Q&A: What is autism? - A personal view

Martin Raff BMC Biology 2010, 8:42 (12 April 2010)

Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

In an interview available either as video or as text, Martin Raff explains what he thinks is wrong with current views of autism, and what genomics will contribute.

		Editorial Genes, animal models and the current understanding of psychiatric disease Penelope Austin BMC Biology 2011, 9:78 (11 November 2011) Full text \| PDF \| PubMed \| Editor’s summary Two articles in our Wiring the Brain series explore the implications of new genetic information on psychiatric disease for clinical practice and for elucidation of the complex biology of disorders of the mind. Penelope Austin explains the two points of view they reflect.
		Opinion Two patients walk into a clinic...a genomics perspective on the future of schizophrenia Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.
		Review Following the genes: a framework for animal modeling of psychiatric disorders Kevin J Mitchell, Z Josh Huang, Bita Moghaddam, Akira Sawa BMC Biology 2011, 9:76 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Following a brief overview of the revolution in psychiatric genetics, Kevin Mitchell and colleagues explain how the effects of causal mutations can be studied in animals to elucidate pathogenic mechanisms and neurobiological phenotypes of direct relevance to human disease.
		Questions & Answers Machine learning for neuroscience Geoffrey E Hinton Neural Systems & Circuits 2011, 1:12 (15 August 2011) Abstract \| Full text \| PDF
		Comment The miswired brain: making connections from neurodevelopment to psychopathology Kevin J Mitchell BMC Biology 2011, 9:23 (12 April 2011) Full text \| PDF \| PubMed \| Editor’s summary In a brief comment, Kevin Mitchell discusses the implications of the convergence of neuropsychiatric genetics on genes involved in neurodevelopment, outlining the challenge of linking the primary mutations to the final pathology, and explaining how mouse models can help.
		Research article Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex Claude M Schofield, Ruby Hsu, Alison J Barker, Caitlyn C Gertz, Robert Blelloch, Erik M Ullian Neural Development 2011, 6:11 (5 April 2011) Abstract \| Full text \| PDF \| PubMed
		Research A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism John P Hussman, Ren-Hua Chung, Anthony J Griswold, James M Jaworski, Daria Salyakina, Deqiong Ma, Ioanna Konidari, Patrice L Whitehead, Jeffery M Vance, Eden R Martin, Michael L Cuccaro, John R Gilbert, Jonathan L Haines, Margaret A Pericak-Vance Molecular Autism 2011, 2:1 (19 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype Noelle D Dwyer, Danielle K Manning, Jennifer L Moran, Raksha Mudbhary, Michael S Fleming, Carlita B Favero, Vita M Vock, Dennis DM O'Leary, Christopher A Walsh, David R Beier Neural Development 2011, 6:3 (7 January 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Screening for genes that wire the cerebral cortex Ludmilla Lokmane, Sonia Garel BMC Biology 2011, 9:1 (7 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Commenting on a paper in Neural Development, Ludmilla Lokmane and Sonia Garel explain how this has demonstrated the feasibility of a forward genetic approach to understanding mammalian brain morphogenesis and wiring.
		Research Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication Ozlem Bozdagi, Takeshi Sakurai, Danae Papapetrou, Xiaobin Wang, Dara L Dickstein, Nagahide Takahashi, Yuji Kajiwara, Mu Yang, Adam M Katz, Maria Scattoni, Mark J Harris, Roheeni Saxena, Jill L Silverman, Jacqueline N Crawley, Qiang Zhou, Patrick R Hof, Joseph D Buxbaum Molecular Autism 2010, 1:15 (17 December 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Recent discovery may explain how mutations affecting SHANK3 may lead to autism spectrum disorders
		Question and Answer Video Q&A: What is autism? - A personal view Martin Raff BMC Biology 2010, 8:42 (12 April 2010) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an interview available either as video or as text, Martin Raff explains what he thinks is wrong with current views of autism, and what genomics will contribute.

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Wiring the brain