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Non-coding RNA

Collection published: 3 June 2013

Last updated: 20 August 2013

RNA There is increasing evidence that non-coding RNAs play a major role in epigenetic regulation. This article collection focuses on understanding the mechanisms of non-coding RNA, describing insights into the biogenesis and activity of non-coding RNAs, their interaction with chromatin, and novel methods for analysis and manipulation of RNA-mediated regulation.

		Short report Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs Babak Alaei-Mahabadi, Erik Larsson Silence 2013, 4:4 (20 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton, Carolyn J Brown Epigenetics & Chromatin 2013, 6:23 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Analysis of hairpin RNA transgene-induced gene silencing in Fusarium oxysporum Ulrike Schumann, Neil A Smith, Kemal Kazan, Michael Ayliffe, Ming-Bo Wang Silence 2013, 4:3 (2 July 2013) Abstract \| Full text \| PDF \| PubMed
		Review UpSETing chromatin during non-coding RNA production Swaminathan Venkatesh, Jerry L Workman, Michaela Smolle Epigenetics & Chromatin 2013, 6:16 (5 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods cWords - systematic microRNA regulatory motif discovery from mRNA expression data Simon H Rasmussen, Anders Jacobsen, Anders Krogh Silence 2013, 4:2 (20 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana Thanh Theresa Dinh, Michael O’Leary, So Youn Won, Shengben Li, Lorena Arroyo, Xigang Liu, Andrew Defries, Binglian Zheng, Sean R Cutler, Xuemei Chen Silence 2013, 4:1 (5 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection Zhao Zhang, William E Theurkauf, Zhiping Weng, Phillip D Zamore Silence 2012, 3:9 (28 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research Mediator regulates non-coding RNA transcription at fission yeast centromeres Michael Thorsen, Heidi Hansen, Michela Venturi, Steen Holmberg, Genevieve Thon Epigenetics & Chromatin 2012, 5:19 (21 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research MicroRNAs from the same precursor have different targeting properties Antonio Marco, Jamie I MacPherson, Matthew Ronshaugen, Sam Griffiths-Jones Silence 2012, 3:8 (27 September 2012) Abstract \| Full text \| PDF \| PubMed
		Methods Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana So Youn Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huilan Yi, Lei Gao, Thanh Theresa Dinh, Xuemei Chen Silence 2012, 3:6 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A luciferase-based reporter system, LUCH, is used to screen for bidirectional mutants that enhance or suppress transcriptional gene silencing, elucidating the mechanisms of DNA methylation and demethylation.
		Review Application of RNA silencing to plant disease resistance Cheng-Guo Duan, Chun-Han Wang, Hui-Shan Guo Silence 2012, 3:5 (31 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hui-Shan Guo and colleagues review the application of RNA silencing in engineering plants that are resistant to plant viruses, viroids, insects and, more recently, fungal pathogens.
		Short report Reducing ligation bias of small RNAs in libraries for next generation sequencing Karim Sorefan, Helio Pais, Adam E Hall, Ana Kozomara, Sam Griffiths-Jones, Vincent Moulton, Tamas Dalmay Silence 2012, 3:4 (30 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments Takaya Saito, Pål Sætrom Silence 2012, 3:3 (10 February 2012) Abstract \| Full text \| PDF \| PubMed
		Minireview Noncoding RNA localisation mechanisms in chromatin regulation Aditi Kanhere, Richard G Jenner Silence 2012, 3:2 (31 January 2012) Abstract \| Full text \| PDF \| PubMed
		Review Inhibition of microRNA function by antimiR oligonucleotides Jan Stenvang, Andreas Petri, Morten Lindow, Susanna Obad, Sakari Kauppinen Silence 2012, 3:1 (9 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA Lisa Korostowski, Anjali Raval, Gillian Breuer, Nora Engel Epigenetics & Chromatin 2011, 4:21 (15 November 2011) Abstract \| Full text \| PDF \| PubMed
		Minireview The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression Dirk Grimm Silence 2011, 2:8 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment
		Research Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Cédric Belair, Jessica Baud, Sandrine Chabas, Cynthia M Sharma, Jörg Vogel, Cathy Staedel, Fabien Darfeuille Silence 2011, 2:7 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells Tatyana B Nesterova, Claire E Senner, Janina Schneider, Tilly Alcayna-Stevens, Anna Tattermusch, Myriam Hemberger, Neil Brockdorff Epigenetics & Chromatin 2011, 4:17 (7 October 2011) Abstract \| Full text \| PDF \| PubMed
		Meeting report Noncoding RNAs and cancer Ohad Yogev, Dimitris Lagos Silence 2011, 2:6 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
		Minireview Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation Michael Johnston, Gyorgy Hutvagner Silence 2011, 2:5 (26 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research *A 5′-uridine amplifies miRNA/miRNA asymmetry in Drosophila by promoting RNA-induced silencing complex formation** Hervé Seitz, Jogender S Tushir, Phillip D Zamore Silence 2011, 2:4 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2 Nikolaus Schultz, Dina R Marenstein, Dino A De Angelis, Wei-Qing Wang, Sven Nelander, Anders Jacobsen, Debora S Marks, Joan Massagué, Chris Sander Silence 2011, 2:3 (14 March 2011) Abstract \| Full text \| PDF \| PubMed
		Review Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments Kevin P McCormick, Matthew R Willmann, Blake C Meyers Silence 2011, 2:2 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors John C Schmitz, Edward Chu Silence 2011, 2:1 (19 January 2011) Abstract \| Full text \| PDF \| PubMed
		Research MicroR159 regulation of most conserved targets in Arabidopsis has negligible phenotypic effects Robert S Allen, Junyan Li, Maria M Alonso-Peral, Rosemary G White, Frank Gubler, Anthony A Millar Silence 2010, 1:18 (28 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions Limor Leibovich, Yael Mandel-Gutfreund, Zohar Yakhini Silence 2010, 1:17 (22 September 2010) Abstract \| Full text \| PDF \| PubMed
		Methodology In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR) Yosef Landesman, Nenad Svrzikapa, Armand Cognetta, Xuemei Zhang, Brian R Bettencourt, Satya Kuchimanchi, Keri Dufault, Sarfraz Shaikh, Maple Gioia, Akin Akinc, Renta Hutabarat, Rachel Meyers Silence 2010, 1:16 (23 August 2010) Abstract \| Full text \| PDF \| PubMed
		Research An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana K Earley, MR Smith, R Weber, BD Gregory, RS Poethig Silence 2010, 1:15 (12 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An endogenous F-box protein negatively regulates the protein levels of ARGONAUTE1, a core component of the RNA-induced silencing complex, and affects the sensitivity of plants to the growth regulator abscisic acid.
		Review A status report on RNAi therapeutics Akshay K Vaishnaw, Jared Gollob, Christina Gamba-Vitalo, Renta Hutabarat, Dinah Sah, Rachel Meyers, Tony de Fougerolles, John Maraganore Silence 2010, 1:14 (8 July 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Meeting report RNA silencing in plants: Flash report! Rebecca A Mosher, Mathew G Lewsey, Padubidri V Shivaprasad Silence 2010, 1:13 (30 June 2010) Abstract \| Full text \| PDF \| PubMed
		Short report Naturally occurring variations in sequence length creates microRNA isoforms that differ in argonaute effector complex specificity H Alexander Ebhardt, Amber Fedynak, Richard P Fahlman Silence 2010, 1:12 (9 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary How do miRNAs mediate translational repression? Shuo Gu, Mark A Kay Silence 2010, 1:11 (7 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation Y Amy Tang, Derek Huntley, Giovanni Montana, Andrea Cerase, Tatyana B Nesterova, Neil Brockdorff Epigenetics & Chromatin 2010, 3:10 (7 May 2010) Abstract \| Full text \| PDF \| PubMed \| f1000
		Methodology Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent Genhua Zheng, Victor Ambros, Wen-hong Li Silence 2010, 1:9 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Dextran was conjugated with 2'-O-methyl oligoribonucleotides to develop fluorescently labeled antisense reagents, which were introduced to the germ line of adult hermaphrodite Caenorhabditis elegans, and caused specific miRNA inhibition in different tissues in the embryonic and larval development of the progeny.
		Research Specificity and functionality of microRNA inhibitors Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen Silence 2010, 1:10 (1 April 2010) Abstract \| Full text \| PDF \| PubMed
		Review Riding in silence: a little snowboarding, a lot of small RNAs Stefan L Ameres, Ryuya Fukunaga Silence 2010, 1:8 (15 March 2010) Abstract \| Full text \| PDF \| PubMed
		Short report microRNA as a new immune-regulatory agent in breast milk Nobuyoshi Kosaka, Hirohisa Izumi, Kazunori Sekine, Takahiro Ochiya Silence 2010, 1:7 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Development of the human cancer microRNA network Sanghamitra Bandyopadhyay, Ramkrishna Mitra, Ujjwal Maulik, Michael Q Zhang Silence 2010, 1:6 (2 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cancer-microRNA network elucidates the association between miRNAs and cancer types. The network indicates neighboring miRNAs are differentially co-expressed, and could be used to detect miRNAs with strong onco/ tumor suppressor characteristics.
		Research Expression patterns of intronic microRNAs in Caenorhabditis elegans Meltem Isik, Hendrik C Korswagen, Eugene Berezikov Silence 2010, 1:5 (1 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Aptamer-targeted cell-specific RNA interference Jiehua Zhou, John J Rossi Silence 2010, 1:4 (1 February 2010) Abstract \| Full text \| PDF \| PubMed
		Review How to slice: snapshots of Argonaute in action James S Parker Silence 2010, 1:3 (12 January 2010) Abstract \| Full text \| PDF \| PubMed
		Research Solution structure of the Drosha double-stranded RNA-binding domain Geoffrey A Mueller, Matthew T Miller, Eugene F DeRose, Mahua Ghosh, Robert E London, Traci Hall Silence 2010, 1:2 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural studies of Drosha, a nuclear RNAse III enzyme, which in complex with DGCR8 initiates processing of miRNAs, reveal that the Drosha-dsRBD retains RNA-binding features, and may contribute to substrate recognition.
		Research Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila Harsh H Kavi, James A Birchler Epigenetics & Chromatin 2009, 2:15 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre Pablo Navarro, Sophie Chantalat, Mario Foglio, Corinne Chureau, Sébastien Vigneau, Philippe Clerc, Philip Avner, Claire Rougeulle Epigenetics & Chromatin 2009, 2:8 (20 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager, Neil Brockdorff Epigenetics & Chromatin 2008, 1:2 (27 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central

		Short report Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs Babak Alaei-Mahabadi, Erik Larsson Silence 2013, 4:4 (20 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton, Carolyn J Brown Epigenetics & Chromatin 2013, 6:23 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Analysis of hairpin RNA transgene-induced gene silencing in Fusarium oxysporum Ulrike Schumann, Neil A Smith, Kemal Kazan, Michael Ayliffe, Ming-Bo Wang Silence 2013, 4:3 (2 July 2013) Abstract \| Full text \| PDF \| PubMed
		Review UpSETing chromatin during non-coding RNA production Swaminathan Venkatesh, Jerry L Workman, Michaela Smolle Epigenetics & Chromatin 2013, 6:16 (5 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods cWords - systematic microRNA regulatory motif discovery from mRNA expression data Simon H Rasmussen, Anders Jacobsen, Anders Krogh Silence 2013, 4:2 (20 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana Thanh Theresa Dinh, Michael O’Leary, So Youn Won, Shengben Li, Lorena Arroyo, Xigang Liu, Andrew Defries, Binglian Zheng, Sean R Cutler, Xuemei Chen Silence 2013, 4:1 (5 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methods Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection Zhao Zhang, William E Theurkauf, Zhiping Weng, Phillip D Zamore Silence 2012, 3:9 (28 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research Mediator regulates non-coding RNA transcription at fission yeast centromeres Michael Thorsen, Heidi Hansen, Michela Venturi, Steen Holmberg, Genevieve Thon Epigenetics & Chromatin 2012, 5:19 (21 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research MicroRNAs from the same precursor have different targeting properties Antonio Marco, Jamie I MacPherson, Matthew Ronshaugen, Sam Griffiths-Jones Silence 2012, 3:8 (27 September 2012) Abstract \| Full text \| PDF \| PubMed
		Methods Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana So Youn Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huilan Yi, Lei Gao, Thanh Theresa Dinh, Xuemei Chen Silence 2012, 3:6 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A luciferase-based reporter system, LUCH, is used to screen for bidirectional mutants that enhance or suppress transcriptional gene silencing, elucidating the mechanisms of DNA methylation and demethylation.
		Review Application of RNA silencing to plant disease resistance Cheng-Guo Duan, Chun-Han Wang, Hui-Shan Guo Silence 2012, 3:5 (31 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hui-Shan Guo and colleagues review the application of RNA silencing in engineering plants that are resistant to plant viruses, viroids, insects and, more recently, fungal pathogens.
		Short report Reducing ligation bias of small RNAs in libraries for next generation sequencing Karim Sorefan, Helio Pais, Adam E Hall, Ana Kozomara, Sam Griffiths-Jones, Vincent Moulton, Tamas Dalmay Silence 2012, 3:4 (30 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments Takaya Saito, Pål Sætrom Silence 2012, 3:3 (10 February 2012) Abstract \| Full text \| PDF \| PubMed
		Minireview Noncoding RNA localisation mechanisms in chromatin regulation Aditi Kanhere, Richard G Jenner Silence 2012, 3:2 (31 January 2012) Abstract \| Full text \| PDF \| PubMed
		Review Inhibition of microRNA function by antimiR oligonucleotides Jan Stenvang, Andreas Petri, Morten Lindow, Susanna Obad, Sakari Kauppinen Silence 2012, 3:1 (9 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA Lisa Korostowski, Anjali Raval, Gillian Breuer, Nora Engel Epigenetics & Chromatin 2011, 4:21 (15 November 2011) Abstract \| Full text \| PDF \| PubMed
		Minireview The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression Dirk Grimm Silence 2011, 2:8 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment
		Research Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Cédric Belair, Jessica Baud, Sandrine Chabas, Cynthia M Sharma, Jörg Vogel, Cathy Staedel, Fabien Darfeuille Silence 2011, 2:7 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells Tatyana B Nesterova, Claire E Senner, Janina Schneider, Tilly Alcayna-Stevens, Anna Tattermusch, Myriam Hemberger, Neil Brockdorff Epigenetics & Chromatin 2011, 4:17 (7 October 2011) Abstract \| Full text \| PDF \| PubMed
		Meeting report Noncoding RNAs and cancer Ohad Yogev, Dimitris Lagos Silence 2011, 2:6 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
		Minireview Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation Michael Johnston, Gyorgy Hutvagner Silence 2011, 2:5 (26 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research *A 5′-uridine amplifies miRNA/miRNA asymmetry in Drosophila by promoting RNA-induced silencing complex formation** Hervé Seitz, Jogender S Tushir, Phillip D Zamore Silence 2011, 2:4 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2 Nikolaus Schultz, Dina R Marenstein, Dino A De Angelis, Wei-Qing Wang, Sven Nelander, Anders Jacobsen, Debora S Marks, Joan Massagué, Chris Sander Silence 2011, 2:3 (14 March 2011) Abstract \| Full text \| PDF \| PubMed
		Review Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments Kevin P McCormick, Matthew R Willmann, Blake C Meyers Silence 2011, 2:2 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors John C Schmitz, Edward Chu Silence 2011, 2:1 (19 January 2011) Abstract \| Full text \| PDF \| PubMed
		Research MicroR159 regulation of most conserved targets in Arabidopsis has negligible phenotypic effects Robert S Allen, Junyan Li, Maria M Alonso-Peral, Rosemary G White, Frank Gubler, Anthony A Millar Silence 2010, 1:18 (28 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions Limor Leibovich, Yael Mandel-Gutfreund, Zohar Yakhini Silence 2010, 1:17 (22 September 2010) Abstract \| Full text \| PDF \| PubMed
		Methodology In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR) Yosef Landesman, Nenad Svrzikapa, Armand Cognetta, Xuemei Zhang, Brian R Bettencourt, Satya Kuchimanchi, Keri Dufault, Sarfraz Shaikh, Maple Gioia, Akin Akinc, Renta Hutabarat, Rachel Meyers Silence 2010, 1:16 (23 August 2010) Abstract \| Full text \| PDF \| PubMed
		Research An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana K Earley, MR Smith, R Weber, BD Gregory, RS Poethig Silence 2010, 1:15 (12 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An endogenous F-box protein negatively regulates the protein levels of ARGONAUTE1, a core component of the RNA-induced silencing complex, and affects the sensitivity of plants to the growth regulator abscisic acid.
		Review A status report on RNAi therapeutics Akshay K Vaishnaw, Jared Gollob, Christina Gamba-Vitalo, Renta Hutabarat, Dinah Sah, Rachel Meyers, Tony de Fougerolles, John Maraganore Silence 2010, 1:14 (8 July 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Meeting report RNA silencing in plants: Flash report! Rebecca A Mosher, Mathew G Lewsey, Padubidri V Shivaprasad Silence 2010, 1:13 (30 June 2010) Abstract \| Full text \| PDF \| PubMed
		Short report Naturally occurring variations in sequence length creates microRNA isoforms that differ in argonaute effector complex specificity H Alexander Ebhardt, Amber Fedynak, Richard P Fahlman Silence 2010, 1:12 (9 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary How do miRNAs mediate translational repression? Shuo Gu, Mark A Kay Silence 2010, 1:11 (7 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation Y Amy Tang, Derek Huntley, Giovanni Montana, Andrea Cerase, Tatyana B Nesterova, Neil Brockdorff Epigenetics & Chromatin 2010, 3:10 (7 May 2010) Abstract \| Full text \| PDF \| PubMed \| f1000
		Methodology Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent Genhua Zheng, Victor Ambros, Wen-hong Li Silence 2010, 1:9 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Dextran was conjugated with 2'-O-methyl oligoribonucleotides to develop fluorescently labeled antisense reagents, which were introduced to the germ line of adult hermaphrodite Caenorhabditis elegans, and caused specific miRNA inhibition in different tissues in the embryonic and larval development of the progeny.
		Research Specificity and functionality of microRNA inhibitors Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen Silence 2010, 1:10 (1 April 2010) Abstract \| Full text \| PDF \| PubMed
		Review Riding in silence: a little snowboarding, a lot of small RNAs Stefan L Ameres, Ryuya Fukunaga Silence 2010, 1:8 (15 March 2010) Abstract \| Full text \| PDF \| PubMed
		Short report microRNA as a new immune-regulatory agent in breast milk Nobuyoshi Kosaka, Hirohisa Izumi, Kazunori Sekine, Takahiro Ochiya Silence 2010, 1:7 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Development of the human cancer microRNA network Sanghamitra Bandyopadhyay, Ramkrishna Mitra, Ujjwal Maulik, Michael Q Zhang Silence 2010, 1:6 (2 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cancer-microRNA network elucidates the association between miRNAs and cancer types. The network indicates neighboring miRNAs are differentially co-expressed, and could be used to detect miRNAs with strong onco/ tumor suppressor characteristics.
		Research Expression patterns of intronic microRNAs in Caenorhabditis elegans Meltem Isik, Hendrik C Korswagen, Eugene Berezikov Silence 2010, 1:5 (1 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Aptamer-targeted cell-specific RNA interference Jiehua Zhou, John J Rossi Silence 2010, 1:4 (1 February 2010) Abstract \| Full text \| PDF \| PubMed
		Review How to slice: snapshots of Argonaute in action James S Parker Silence 2010, 1:3 (12 January 2010) Abstract \| Full text \| PDF \| PubMed
		Research Solution structure of the Drosha double-stranded RNA-binding domain Geoffrey A Mueller, Matthew T Miller, Eugene F DeRose, Mahua Ghosh, Robert E London, Traci Hall Silence 2010, 1:2 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural studies of Drosha, a nuclear RNAse III enzyme, which in complex with DGCR8 initiates processing of miRNAs, reveal that the Drosha-dsRBD retains RNA-binding features, and may contribute to substrate recognition.
		Research Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila Harsh H Kavi, James A Birchler Epigenetics & Chromatin 2009, 2:15 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre Pablo Navarro, Sophie Chantalat, Mario Foglio, Corinne Chureau, Sébastien Vigneau, Philippe Clerc, Philip Avner, Claire Rougeulle Epigenetics & Chromatin 2009, 2:8 (20 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager, Neil Brockdorff Epigenetics & Chromatin 2008, 1:2 (27 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central