Nutrition and metabolism in health and disease
Collection published: 28 May 2012
Last updated: 23 January 2013
Lifestyle-related diseases such as diabetes and cancer represent one of the greatest challenges to health and wellbeing in the developed world. These complex disorders are difficult to treat effectively, and are increasingly prevalent as sedentary lifestyles and calorie-rich, nutrient-poor diets cause an obesity crisis throughout the developed world. The Metabolism, Diet and Disease conference aims to show how basic research on the biochemistry, cell biology and genetics of metabolism can address the major health problems of cancer, obesity, diabetes and insulin resistance, and can explain ageing and longevity.
In addition, the conference provides a forum to explore the role of lifestyle factors such as diet in disease. This cross-journal collection builds on these aims by using research from across the fields of nutrition, metabolism and oncology to investigate disease prevention and treatment using both lifestyle changes and pharmacological interventions.
The series aims to address the complex nature of these disorders by looking at the links between metabolism, lifestyle and disease. It combines research and reviews published in Nutrition & Metabolism, Diabetology & Metabolic Syndrome, Nutrition Journal, Cardiovascular Diabetology, Journal of Experimental & Clinical Cancer Research, Journal of Translational Medicine (Nutrition & Metabolism Section), Molecular Cancer and Cancer and Metabolism. We welcome further submissions on this topic.
If you have a manuscript that you would like to be considered for the series please submit it via the online submission system for the relevant journal, and state clearly in the covering letter that it is intended for this thematic series. Before submitting your manuscript, please read the 'instructions for authors', for the relevant journal.
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Activated lymphocytes as a metabolic model for carcinogenesis
Andrew N Macintyre, Jeffrey C Rathmell Cancer & Metabolism 2013, 1:5 (23 January 2013)
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Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti, Gary Siuzdak Cancer & Metabolism 2013, 1:4 (23 January 2013)
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris, Almut Schulze Cancer & Metabolism 2013, 1:3 (23 January 2013)
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Editor’s summary
Akt/mTORC1 signalling via SREBP was shown to coordinate lipid and protein biosynthesis in both normal and cancer cells, while ablation of this pathway caused ER stress, apoptosis and cell death and prevented tumor growth in a mouse model. |
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Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
Timothy R Gershon, Andrew J Crowther, Andrey Tikunov, Idoia Garcia, Ryan Annis, Hong Yuan, C Miller, Jeffrey Macdonald, James Olson, Mohanish Deshmukh Cancer & Metabolism 2013, 1:2 (23 January 2013)
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The Warburg effect, where cancer cells switch to aerobic glycolysis for their metabolic requirements, was observed in normal cerebellum development, as well as in medulloblastoma where it contributed to tumorogenesis. |
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Using 3–6 differences in essential fatty acids rather than 3/6 ratios gives useful food balance scores
Bill Lands, Etienne Lamoreaux Nutrition & Metabolism 2012, 9:46 (24 May 2012)
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Editor’s summary
Overabundance of omega 6 is associated with breast cancer and cardiovascular disorders. This nutritional food score identifies foods with optimum omega 3/6 balance, aiding nutritional decision-making.
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Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro
Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vítor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota-Pinto, Carlos Lopes, Rui Medeiros Journal of Experimental & Clinical Cancer Research 2012, 31:32 (2 April 2012)
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A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects
Juscelino Tovar, Anne Nilsson, Maria Johansson, Rickard Ekesbo, Ann-Margreth Åberg, Ulla Johansson, Inger Björck Nutrition & Metabolism 2012, 9:29 (2 April 2012)
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The chronic effects of fish oil with exercise on postprandial lipaemia and chylomicron homeostasis in insulin resistant viscerally obese men
Karin M Slivkoff-Clark, Anthony P James, John CL Mamo Nutrition & Metabolism 2012, 9:9 (7 February 2012)
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The mechanisms by which polyamines accelerate tumor spread
Kuniyasu Soda Journal of Experimental & Clinical Cancer Research 2011, 30:95 (11 October 2011)
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Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview
Monica Marra, Ignazio M Sordelli, Angela Lombardi, Monica Lamberti, Luciano Tarantino, Aldo Giudice, Paola Stiuso, Alberto Abbruzzese, Rossella Sperlongano, Marina Accardo, Massimo Agresti, Michele Caraglia, Pasquale Sperlongano Journal of Translational Medicine 2011, 9:171 (10 October 2011)
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Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
John F Trepanowski, Robert E Canale, Kate E Marshall, Mohammad M Kabir, Richard J Bloomer Nutrition Journal 2011, 10:107 (7 October 2011)
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Biochemical Study of Oxidative Stress Markers in the Liver, Kidney and Heart of High Fat Diet Induced Obesity in Rats
Saad A Noeman, Hala E Hamooda, Amal A Baalash Diabetology & Metabolic Syndrome 2011, 3:17 (3 August 2011)
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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial
Melanie Schmidt, Nadja Pfetzer, Micheal Schwab, Ingrid Strauss, Ulrike Kämmerer Nutrition & Metabolism 2011, 8:54 (27 July 2011)
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Visceral adiposity, insulin resistance and cancer risk
Claire L Donohoe, Suzanne L Doyle, John V Reynolds Diabetology & Metabolic Syndrome 2011, 3:12 (22 June 2011)
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The metabolic advantage of tumor cells
Maurice Israël, Laurent Schwartz Molecular Cancer 2011, 10:70 (7 June 2011)
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Pharmacological and non-pharmacological interventions to influence adipose tissue function
Jan Westerink, Frank LJ Visseren Cardiovascular Diabetology 2011, 10:13 (28 January 2011)
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Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties
Edite Teixeira-Lemos, Sara Nunes, Frederico Teixeira, Flávio Reis Cardiovascular Diabetology 2011, 10:12 (28 January 2011)
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