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Advances in food allergy

Collection published: 2 January 2012

Last updated: 8 July 2013

Image: courtesy of dcastor, creative commons Food allergy can be lifestyle changing and as a leading cause of anaphylaxis it can also be life-threatening. The incidence of food allergy in children aged 0-5 is thought to have doubled in the last 10 years, and continues to affect millions of adults.

Awareness and diagnosis of food allergy as well as effective management and treatment for sufferers is imperative in order to prevent life-threatening events. Key areas of focus to aid further understanding of food hypersensitivity as well as to help provide improved support for patients include:

epidemiology of food allergy
diagnosis, from clinical to molecular
mechanisms involved in sensitisation
allergy manifestations and tolerance
predictive factors
active treatment options both allergen-specific and non allergen-specific

This cross-journal collection brings together the findings published in BioMed Central's allergy journals. We hope that this coordinated focus on food allergy will help to raise awareness and stimulate interest within the community.

Image: courtesy of dcastor, creative commons

		Review Diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy - a UK primary care practical guide Carina Venter, Trevor Brown, Neil Shah, Joanne Walsh, Adam T Fox Clinical and Translational Allergy 2013, 3:23 (8 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods Sven-Arne Jansson, Marianne Heibert-Arnlind, Roelinde JM Middelveld, Ulf J Bengtsson, Ann-Charlotte Sundqvist, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Johanna Åkerström, Eva Östblom, Sven-Erik Dahlén, Staffan Ahlstedt Clinical and Translational Allergy 2013, 3:21 (1 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Experiencing a first food allergic reaction: a survey of parent and caregiver perspectives Zainab B Abdurrahman, Monika Kastner, Cory Wurman, Laurie Harada, Laura Bantock, Heather Cruickshank, Susan Waserman Allergy, Asthma & Clinical Immunology 2013, 9:18 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Parents of children who have an allergic food reaction do not receive sufficient information about allergy management, identifying a reaction, nor anxiety management until referred to an allergist, suggesting improvements are required in first line healthcare.
		Case report Proposed new mechanism for food and exercise induced anaphylaxis based on case studies Jennifer Yan Fei Chen, Jaclyn Quirt, Kihyuk Jason Lee Allergy, Asthma & Clinical Immunology 2013, 9:11 (20 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Persistence of peanut allergen on a table surface Wade TA Watson, AnnMarie Woodrow, Andrew W Stadnyk Allergy, Asthma & Clinical Immunology 2013, 9:7 (18 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peanut allergen remained present on a table top for 110 days, without degradation, and was removed on cleaning, reinforcing the importance of cleaning surfaces before and after eating for peanut allergen sufferers.
		Brief communication Inability to detect significant absorption of immunoreactive soya protein in healthy adults may be relevant to its weak allergenicity Cecilia M Lund, Christina G Dirks, Mona H Pedersen, Bettina M Jensen, Lars K Poulsen Clinical and Translational Allergy 2013, 3:6 (4 February 2013) Abstract \| Full text \| PDF \| PubMed
		Review Food allergies in developing and emerging economies: need for comprehensive data on prevalence rates Joyce Irene Boye Clinical and Translational Allergy 2012, 2:25 (20 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research The 11S globulin Sin a 2 from yellow mustard seeds shows IgE cross-reactivity with homologous counterparts from tree nuts and peanut Sofía Sirvent, Martial Akotenou, Javier Cuesta-Herranz, Andrea Vereda, Rosalía Rodríguez, Mayte Villalba, Oscar Palomares Clinical and Translational Allergy 2012, 2:23 (11 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research Intact skin and not stripped skin is crucial for the safety and efficacy of peanut epicutaneous immunotherapy (EPIT) in mice Lucie Mondoulet, Vincent Dioszeghy, Emilie Puteaux, Mélanie Ligouis, Véronique Dhelft, Franck Letourneur, Christophe Dupont, Pierre-Henri Benhamou Clinical and Translational Allergy 2012, 2:22 (12 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis Steven Maltby, Erin J DeBruin, Jami Bennett, Matthew J Gold, Matthew C Tunis, Zhiqi Jian, Jean S Marshall, Kelly M McNagny Allergy, Asthma & Clinical Immunology 2012, 8:15 (31 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research The strategies that peanut and nut-allergic consumers employ to remain safe when travelling abroad Julie Barnett, Neil Botting, M Gowland, Jane S Lucas Clinical and Translational Allergy 2012, 2:12 (9 July 2012) Abstract \| Full text \| PDF \| PubMed
		Research Predictive value of IgE/IgG₄ antibody ratio in children with egg allergy Shindou Okamoto, Shoichiro Taniuchi, Kyoko Sudo, Yasuko Hatano, Keiji Nakano, Tomohiko Shimo, Kazunari Kaneko Allergy, Asthma & Clinical Immunology 2012, 8:9 (7 June 2012) Abstract \| Full text \| PDF \| PubMed
		Correspondence Can dietary fibre help provide safer food products for sufferers of gluten intolerance? A well-established biophysical probe may help towards providing an answer M Kök, Richard Gillis, Shirley Ang, David Lafond, Arthur S Tatham, Gary Adams, Stephen E Harding BMC Biophysics 2012, 5:10 (17 May 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Stephen Harding and colleagues speculate on the role that the ultracentrifuge assay procedure could play in detecting non-toxic biopolymers capable of sequestering ingested gluten peptides, with the eventual aim of reducing gluten intolerance symptoms.
		Research Skin prick testing with extensively heated milk or egg products helps predict the outcome of an oral food challenge: a retrospective analysis Zein Faraj, Harold L Kim Allergy, Asthma & Clinical Immunology 2012, 8:5 (16 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research What are the beliefs of pediatricians and dietitians regarding complementary food introduction to prevent allergy? Sara Leo, John Dean, Edmond S Chan Allergy, Asthma & Clinical Immunology 2012, 8:3 (21 March 2012) Abstract \| Full text \| PDF \| PubMed
		Review FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies Laurian Zuidmeer-Jongejan, Montserrat Fernandez-Rivas, Lars K Poulsen, Angela Neubauer, Juan Asturias, Lars Blom, Joyce Boye, Carsten Bindslev-Jensen, Michael Clausen, Rosa Ferrara, Paula Garosi, Hans Huber, Bettina M Jensen, Stef Koppelman, Marek L Kowalski, Anna Lewandowska-Polak, Birgit Linhart, Bernard Maillere, Adriano Mari, Alberto Martinez, Clare EN Mills, Claudio Nicoletti, Dirk-Jan Opstelten, Nikos G Papadopoulos, Antonio Portoles, Neil Rigby, Enrico Scala, Heidi J Schnoor, Sigurveig T Sigurdardottir, George Stavroulakis et al. Clinical and Translational Allergy 2012, 2:5 (9 March 2012) Abstract \| Full text \| PDF \| PubMed
		Review Anaphylactic Reactions to Oligosaccharides in Red Meat: a Syndrome in Evolution Hana Saleh, Scott Embry, Andromeda Nauli, Seif Atyia, Guha Krishnaswamy Clinical and Molecular Allergy 2012, 10:5 (7 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research No systemic reactions to influenza vaccination in egg-sensitized tertiary-care pediatric patients Julia Upton, David Hummel, Anna Kasprzak, Adelle Atkinson Allergy, Asthma & Clinical Immunology 2012, 8:2 (2 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children Komei Ito, Masaki Futamura, Robert Movérare, Akira Tanaka, Tsutomu Kawabe, Tatsuo Sakamoto, Magnus P Borres Clinical and Molecular Allergy 2012, 10:1 (2 January 2012) Abstract \| Full text \| PDF \| PubMed

		Review Diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy - a UK primary care practical guide Carina Venter, Trevor Brown, Neil Shah, Joanne Walsh, Adam T Fox Clinical and Translational Allergy 2013, 3:23 (8 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods Sven-Arne Jansson, Marianne Heibert-Arnlind, Roelinde JM Middelveld, Ulf J Bengtsson, Ann-Charlotte Sundqvist, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Johanna Åkerström, Eva Östblom, Sven-Erik Dahlén, Staffan Ahlstedt Clinical and Translational Allergy 2013, 3:21 (1 July 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Experiencing a first food allergic reaction: a survey of parent and caregiver perspectives Zainab B Abdurrahman, Monika Kastner, Cory Wurman, Laurie Harada, Laura Bantock, Heather Cruickshank, Susan Waserman Allergy, Asthma & Clinical Immunology 2013, 9:18 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Parents of children who have an allergic food reaction do not receive sufficient information about allergy management, identifying a reaction, nor anxiety management until referred to an allergist, suggesting improvements are required in first line healthcare.
		Case report Proposed new mechanism for food and exercise induced anaphylaxis based on case studies Jennifer Yan Fei Chen, Jaclyn Quirt, Kihyuk Jason Lee Allergy, Asthma & Clinical Immunology 2013, 9:11 (20 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research Persistence of peanut allergen on a table surface Wade TA Watson, AnnMarie Woodrow, Andrew W Stadnyk Allergy, Asthma & Clinical Immunology 2013, 9:7 (18 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peanut allergen remained present on a table top for 110 days, without degradation, and was removed on cleaning, reinforcing the importance of cleaning surfaces before and after eating for peanut allergen sufferers.
		Brief communication Inability to detect significant absorption of immunoreactive soya protein in healthy adults may be relevant to its weak allergenicity Cecilia M Lund, Christina G Dirks, Mona H Pedersen, Bettina M Jensen, Lars K Poulsen Clinical and Translational Allergy 2013, 3:6 (4 February 2013) Abstract \| Full text \| PDF \| PubMed
		Review Food allergies in developing and emerging economies: need for comprehensive data on prevalence rates Joyce Irene Boye Clinical and Translational Allergy 2012, 2:25 (20 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research The 11S globulin Sin a 2 from yellow mustard seeds shows IgE cross-reactivity with homologous counterparts from tree nuts and peanut Sofía Sirvent, Martial Akotenou, Javier Cuesta-Herranz, Andrea Vereda, Rosalía Rodríguez, Mayte Villalba, Oscar Palomares Clinical and Translational Allergy 2012, 2:23 (11 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research Intact skin and not stripped skin is crucial for the safety and efficacy of peanut epicutaneous immunotherapy (EPIT) in mice Lucie Mondoulet, Vincent Dioszeghy, Emilie Puteaux, Mélanie Ligouis, Véronique Dhelft, Franck Letourneur, Christophe Dupont, Pierre-Henri Benhamou Clinical and Translational Allergy 2012, 2:22 (12 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis Steven Maltby, Erin J DeBruin, Jami Bennett, Matthew J Gold, Matthew C Tunis, Zhiqi Jian, Jean S Marshall, Kelly M McNagny Allergy, Asthma & Clinical Immunology 2012, 8:15 (31 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research The strategies that peanut and nut-allergic consumers employ to remain safe when travelling abroad Julie Barnett, Neil Botting, M Gowland, Jane S Lucas Clinical and Translational Allergy 2012, 2:12 (9 July 2012) Abstract \| Full text \| PDF \| PubMed
		Research Predictive value of IgE/IgG₄ antibody ratio in children with egg allergy Shindou Okamoto, Shoichiro Taniuchi, Kyoko Sudo, Yasuko Hatano, Keiji Nakano, Tomohiko Shimo, Kazunari Kaneko Allergy, Asthma & Clinical Immunology 2012, 8:9 (7 June 2012) Abstract \| Full text \| PDF \| PubMed
		Correspondence Can dietary fibre help provide safer food products for sufferers of gluten intolerance? A well-established biophysical probe may help towards providing an answer M Kök, Richard Gillis, Shirley Ang, David Lafond, Arthur S Tatham, Gary Adams, Stephen E Harding BMC Biophysics 2012, 5:10 (17 May 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Stephen Harding and colleagues speculate on the role that the ultracentrifuge assay procedure could play in detecting non-toxic biopolymers capable of sequestering ingested gluten peptides, with the eventual aim of reducing gluten intolerance symptoms.
		Research Skin prick testing with extensively heated milk or egg products helps predict the outcome of an oral food challenge: a retrospective analysis Zein Faraj, Harold L Kim Allergy, Asthma & Clinical Immunology 2012, 8:5 (16 May 2012) Abstract \| Full text \| PDF \| PubMed
		Research What are the beliefs of pediatricians and dietitians regarding complementary food introduction to prevent allergy? Sara Leo, John Dean, Edmond S Chan Allergy, Asthma & Clinical Immunology 2012, 8:3 (21 March 2012) Abstract \| Full text \| PDF \| PubMed
		Review FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies Laurian Zuidmeer-Jongejan, Montserrat Fernandez-Rivas, Lars K Poulsen, Angela Neubauer, Juan Asturias, Lars Blom, Joyce Boye, Carsten Bindslev-Jensen, Michael Clausen, Rosa Ferrara, Paula Garosi, Hans Huber, Bettina M Jensen, Stef Koppelman, Marek L Kowalski, Anna Lewandowska-Polak, Birgit Linhart, Bernard Maillere, Adriano Mari, Alberto Martinez, Clare EN Mills, Claudio Nicoletti, Dirk-Jan Opstelten, Nikos G Papadopoulos, Antonio Portoles, Neil Rigby, Enrico Scala, Heidi J Schnoor, Sigurveig T Sigurdardottir, George Stavroulakis et al. Clinical and Translational Allergy 2012, 2:5 (9 March 2012) Abstract \| Full text \| PDF \| PubMed
		Review Anaphylactic Reactions to Oligosaccharides in Red Meat: a Syndrome in Evolution Hana Saleh, Scott Embry, Andromeda Nauli, Seif Atyia, Guha Krishnaswamy Clinical and Molecular Allergy 2012, 10:5 (7 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research No systemic reactions to influenza vaccination in egg-sensitized tertiary-care pediatric patients Julia Upton, David Hummel, Anna Kasprzak, Adelle Atkinson Allergy, Asthma & Clinical Immunology 2012, 8:2 (2 March 2012) Abstract \| Full text \| PDF \| PubMed
		Research The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children Komei Ito, Masaki Futamura, Robert Movérare, Akira Tanaka, Tsutomu Kawabe, Tatsuo Sakamoto, Magnus P Borres Clinical and Molecular Allergy 2012, 10:1 (2 January 2012) Abstract \| Full text \| PDF \| PubMed