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1.
Characterizing microclimate in urban transmission settings: a case study from Chennai, India
Lauren J Cator, Shalu Thomas, Krijn P Paaijmans, Sangamithra Ravishankaran, Johnson A Justin, Manu T Mathai, Andrew F Read, Matthew B Thomas, Alex Eapen Malaria Journal 2013, 12 :84 (2 March 2013)
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Editor’s summary
Environmental temperature is an important driver of malaria transmission dynamics. A pilot study conducted in the Indian city of Chennai in which temperatures were measured at predicted resting and transmission sites to better model a realistic extrinsic incubation period in various microclimates
2.
Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali
Drissa Coulibaly, Stanislas Rebaudet, Mark Travassos, Youssouf Tolo, Matthew Laurens, Abdoulaye K Kone, Karim Traore, Ando Guindo, Issa Diarra, Amadou Niangaly, Modibo Daou, Ahmadou Dembele, Mody Sissoko, Bourema Kouriba, Nadine Dessay, Jean Gaudart, Renaud Piarroux, Mahamadou A Thera, Christopher V Plowe, Ogobara K Doumbo Malaria Journal 2013, 12 :82 (1 March 2013)
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Describes the spatial and temporal variation of Plasmodium falciparum infections in children from a rural population from Mali, based on a longitudinal study on malaria incidence in Bandiagara. The spatial and temporal variation of malaria incidence is mapped and interpolated. Clusters of low incidence are identified.
3.
The effect of an anti-malarial subsidy programme on the quality of service provision of artemisinin-based combination therapy in Kenya: a cluster-randomized, controlled trial
Beth P Kangwana, Sarah V Kedenge, Abdisalan M Noor, Victor A Alegana, Andrew J Nyandigisi, Jayesh Pandit, Greg W Fegan, Jim Todd, Robert W Snow, Catherine A Goodman Malaria Journal 2013, 12 :81 (1 March 2013)
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Editor’s summary
This important pharmacy survey indicates that there is much to do about training, supervision and follow-up for those dispensing anti-malarials and other drugs in Kenya and elsewhere in Africa.
4.
A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso
Alfred B Tiono, Alphonse Ouédraogo, Bernhards Ogutu, Amidou Diarra, Sam Coulibaly, Adama Gansané, Sodiomon B Sirima, Gregory O¿Neil, Amitava Mukhopadhyay, Kamal Hamed Malaria Journal 2013, 12 :79 (27 February 2013)
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Editor’s summary
Study of the impact of RDT-based screening and treatment on seasonal malaria in Burkina Faso.
5.
Diversity of the var gene family of Indonesian Plasmodium falciparum isolates
Erma Sulistyaningsih, Loeki E Fitri, Thomas Löscher, Nicole Berens-Riha Malaria Journal 2013, 12 :80 (27 February 2013)
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Editor’s summary
A very thorough analysis of DBL sequences derived from P. falciparum samples from Indonesia, in particular the DBLa and DBlb domains of the var genes are studied and related to disease severity and ICAM-1 binding.
6.
Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
Hamisi M Malebo, Tanja Wenzler, Monical Cal, Sauda M Swaleh, Maurice O Omolo, Ahmed Hassanali, Urs Séquin, Daniel Häussinger, Petur Dalsgaard, Matthias Hamburger, Reto Brun, Isaiah O Ndiege BMC Complementary and Alternative Medicine 2013, 13 :48 (27 February 2013)
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7.
A Poisson hierarchical modelling approach to detecting copy number variation in sequence coverage data
Nuno Sepúlveda, Susana G Campino, Samuel A Assefa, Colin J Sutherland, Arnab Pain, Taane G Clark BMC Genomics 2013, 14 :128 (26 February 2013)
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8.
A dynamic model of some malaria-transmitting anopheline mosquitoes of the Afrotropical region. II. Validation of species distribution and seasonal variations
Torleif M Lunde, Meshesha Balkew, Diriba Korecha, Teshome Gebre-Michael, Fekadu Massebo, Asgeir Sorteberg, Bernt Lindtjørn Malaria Journal 2013, 12 :78 (25 February 2013)
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Editor’s summary
Validation of a mathematical model described earlier. Overall, the model gives a realistic representation of seasonal and year-to-year variability in mosquito densities and it can accurately predict the distribution of An. gambiae s.s. and An. arabiensis in sub-Saharan Africa. It may be used for seasonal and long-term predictions of changes in the burden of malaria.
9.
Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study
Olivier JT Briët, Melissa A Penny, Diggory Hardy, Taiwo S Awolola, Wim Van Bortel, Vincent Corbel, Roch K Dabiré, Josiane Etang, Benjamin G Koudou, Patrick K Tungu, Nakul Chitnis Malaria Journal 2013, 12 :77 (25 February 2013)
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Editor’s summary
The paper shows that standard and combination LLINs are likely to be cost effective against malaria even in areas with strong pyrethroid resistance. There is a strong message to funders and national malaria control programmes not abandon LLINs as the control tool of choice, because of fears that they might no longer be effective due to resistance.
10.
Blood meal sources and entomological inoculation rates of anophelines along a highland altitudinal transect in south-central Ethiopia
Abebe Animut, Meshesha Balkew, Teshome Gebre-Michael, Bernt Lindtjørn Malaria Journal 2013, 12 :76 (23 February 2013)
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Editor’s summary
A good report on the Anopheles fauna found in three different villages located at three different altitudes ranging from 1,800 meters to 2,200 metres, showing the human/cattle blood meal preference for each species and the sporozoite rate and entomological inoculation rate for the vectors.
11.
Perception of malaria risk in a setting of reduced malaria transmission: a qualitative study in Zanzibar
Julie A Bauch, Jessica J Gu, Mwinyi Msellem, Andreas Mårtensson, Abdullah S Ali, Roly Gosling, Kimberly A Baltzell Malaria Journal 2013, 12 :75 (22 February 2013)
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Editor’s summary
A relevant study from Zanzibar, an area where malaria has dropped dramatically in recent years, investigates perceptions of malaria risks among key health staff and villagers in two districts on the islands of Pemba and Unguju.
12.
Can malaria vector control accelerate the interruption of lymphatic filariasis transmission in Africa; capturing a window of opportunity?
Louise A Kelly-Hope, David H Molyneux, Moses J Bockarie Parasites & Vectors 2013, 6 :39 (22 February 2013)
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Editor’s summary
This study examined the potential additive impact of malaria vector control in African countries that are endemic for lymphatic filariasis, and yet to start or fully scale-up mass drug administration for the elimination of disease. Image: Sub-national distribution of bed nets.
13.
Characterization of the complete mitochondrial genome of Spirocerca lupi: sequence, gene organization and phylogenetic implications
Guo-Hua Liu, Yan Wang, Hui-Qun Song, Ming-Wei Li, Lin Ai, Xing-Long Yu, Xing-Quan Zhu Parasites & Vectors 2013, 6 :45 (22 February 2013)
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Editor’s summary
The complete mitochondrial (mt) genome of Spirocerca lupi is 13,780 bp in length, including 12 protein-coding genes, 22 tRNA genes and two rRNA genes, but lacks the atp8 gene, providing novel markers for studying the molecular epidemiology and population genetics of this parasite. Image: Arrangement of Spirocerca lupi mitochondrial genome.
14.
Performance of two rapid diagnostic tests for malaria diagnosis at the China-Myanmar border area
Juan Yan, Nana Li, Xu Wei, Peipei Li, Zhenjun Zhao, Lili Wang, Siying Li, Xiaomei Li, Ying Wang, Shuying Li, Zhaoqing Yang, Bin Zheng, Guofa Zhou, Guiyun Yan, Liwang Cui, Yaming Cao, Qi Fan Malaria Journal 2013, 12 :73 (22 February 2013)
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Editor’s summary
Rapid diagnostic tests have become an essential tool in the contemporary malaria control and management programmes in the world. This study aimed to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area, compared to microscopy and PCR.
15.
Babesia microti: an unusual travel-related disease
Elodie Poisnel, Mikael Ebbo, Yael Berda-Haddad, Benoit Faucher, Emmanuelle Bernit, Bernard Carcy, Renaud Piarroux, Jean-Robert Harlé, Nicolas Schleinitz BMC Infectious Diseases 2013, 13 :99 (22 February 2013)
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16.
Multiple insecticide resistance mechanisms in Anopheles gambiae s.l. populations from Cameroon, Central Africa
Philippe Nwane, Josiane Etang, Mouhamadou Chouaїbou, Jean Toto, Alphonsine Koffi, Rémy Mimpfoundi, Frédéric Simard Parasites & Vectors 2013, 6 :41 (22 February 2013)
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Editor’s summary
This study reveals the involvement of kdr mutations and detoxification enzymes in insecticide resistance of the malaria vector Anopheles gambiae s.l from Cameroon and suggests the potential utility of synergists in mitigating resistance to insecticides. Image: A microplate showing simultaneous identification of kdr alleles in the malaria vector Anopheles gambiae s.l.
17.
Blood meal origins and insecticide susceptibility of Anopheles arabiensis from Chano in South-West Ethiopia
Fekadu Massebo, Meshesha Balkew, Teshome Gebre-Michael, Bernt Lindtjørn Parasites & Vectors 2013, 6 :44 (22 February 2013)
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Editor’s summary
The greater tendency of An. arabiensis to feed on cattle justifies the application of insecticides on cattle to provide a significant protection from malaria infection. But, An. arabiensis has already developed resistance to the available insecticides, and alternative insecticides are needed. Image: Domestic animals are in an open condition every night in the study village.
18.
Comparative field evaluation of combinations of long-lasting insecticide treated nets and indoor residual spraying, relative to either method alone, for malaria prevention in an area where the main vector is Anopheles arabiensis
Fredros O Okumu, Edgar Mbeyela, Godfrey Lingamba, Jason Moore, Alex J Ntamatungiro, Deo R Kavishe, Michael G Kenward, Elizabeth Turner, Lena M Lorenz, Sarah J Moore Parasites & Vectors 2013, 6 :46 (22 February 2013)
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Editor’s summary
Where the primary malaria vector is Anopheles arabiensis, adding IRS into houses with intact pyrethroid based LLINs does not enhance protection, except where the IRS employs highly mosquitocidal non-pyrethroids. In contrast, adding intact nets onto IRS enhances protection by preventing mosquito blood feeding (even if the nets are non-insecticidal) and by modestly increasing mosquito mortality (in case of LLINs). The primary mode of action of intact LLINs against An. arabiensis is demonstrated here to be primarily bite prevention rather than insecticidal activity. Image: A diagrammatic representation of simultaneous use of bednets and indoor residual spraying in the same house.
19.
Improved assay to detect Plasmodium falciparum using an uninterrupted, semi-nested PCR and quantitative lateral flow analysis
Serge Y Ongagna-Yhombi, Paul Corstjens, Eran Geva, William R Abrams, Cheryl A Barber, Daniel Malamud, Sungano Mharakurwa Malaria Journal 2013, 12 :74 (22 February 2013)
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Editor’s summary
An uninterrupted asymmetric single amplification specific semi-nested PCR assay in comparison with traditional nested PCR. This approach provides a basis for migration of the assay to a point-of-care microfluidic format.
20.
The story of artesunate--mefloquine (ASMQ), innovative partnerships in drug development: case study
Susan Wells, Graciela Diap, Jean-René Kiechel Malaria Journal 2013, 12 :68 (21 February 2013)
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Editor’s summary
This is an important paper for people interested in the treatment of malaria and in providing new medicines to populations in developing countries. It describes the developmental process of the fixed combination ASMQ, the trials that were done and the partnerships involved. It is a story that can be seen as an example on how things can be accomplished.
21.
Networking the host immune response in Plasmodium vivax malaria
Vitor RR Mendonça, Artur TL Queiroz, Fabrício M Lopes, Bruno B Andrade, Manoel Barral-Netto Malaria Journal 2013, 12 :69 (21 February 2013)
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Editor’s summary
The clinical outcome of an infection is a consequence of the interaction of multiple factors - parasite, environmental and host factors. This study is a network analysis of different clinical presentations of vivax malaria to identify patterns of association between various candidate biomarkers and the clinical outcome.
22.
Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials
Stephan Duparc, Isabelle Borghini-Fuhrer, J Carl Craft, Sarah Arbe-Barnes, Robert M Miller, Chang-Sik Shin, Lawrence Fleckenstein Malaria Journal 2013, 12 :70 (21 February 2013)
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Editor’s summary
Compilation of efficacy and safety data from pooled analysis of six clinical trials with pyronaridine-artesunate. It offers a valuable comparison with other regimens.
23.
Persistent foci of falciparum malaria among tribes over two decades in Koraput district of Odisha State, India
Sudhansu Sekhar Sahu, Kasinathan Gunasekaran, Perumal Vanamail, Purusothaman Jambulingam Malaria Journal 2013, 12 :72 (21 February 2013)
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Editor’s summary
Results of an epidemiological survey performed in the state of Orissa, in an area where the population of which is predominantly tribal and where malaria is endemic at a relatively high intensity; the prevalence of malaria has increased over the 22 year period.
24.
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
Marli C Lombard, David D N¿Da, Christophe Tran Van Ba, Sharon Wein, Jennifer Norman, Lubbe Wiesner, Henri Vial Malaria Journal 2013, 12 :71 (21 February 2013)
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Editor’s summary
In vivo testing, using the Plasmodium vinckei mouse model, of synthesized artemisinin-aminoquinoline hybrids. A snapshot pharmacokinetic analysis was carried out on one of the hybrids to get an indication of the pharmacokinetic properties of this class of anti-malarial drugs.
25.
Healthcare seeking for diarrhoea, malaria and pneumonia among children in four poor rural districts in Sierra Leone in the context of free health care: results of a cross-sectional survey
Theresa Diaz, Asha S George, Sowmya R Rao, Peter S Bangura, John B Baimba, Shannon A McMahon, Augustin Kabano BMC Public Health 2013, 13 :157 (20 February 2013)
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